Antipicornavirus activity of SCH 47802 and analogs: in vitro and in vivo studies

SCH 47802 and its derivatives are potent inhibitors of enteroviruses in vitro. The IC 50 for SCH 47802 ranges from 0.03 to 10 μg/ml when tested against a spectrum of enteroviruses in plaque reduction assays. The compounds have in vitro therapeutic indices of at least 81 based on viral cytopathic eff...

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Veröffentlicht in:	Antiviral research 1996-10, Vol.32 (2), p.71-79
Hauptverfasser:	Cox, Stuart, Buontempo, Peter J., Wright-Minogue, Jacquelyn, DeMartino, Jason L., Skelton, Angela M., Ferrari, Eric, Schwartz, Jerome, Rozhon, Edward J., Linn, Chin-Chung, Girijavallabhan, V., O'Connell, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agent Antiviral agents Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Biological and medical sciences Capsid - drug effects Cell Line Chlorobenzenes - chemistry Chlorobenzenes - pharmacokinetics Chlorobenzenes - pharmacology Encephalitis, Viral - drug therapy Enteroviruses HeLa Cells Hot Temperature Humans Medical sciences Mice Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments picornaviridae Picornaviridae - drug effects Picornaviridae Infections - drug therapy Picornaviruses SCH 47802
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