Naltrexone and self-injurious behavior : A retrospective population study
The results of studies of the opiate antagonist naltrexone (NLTX) in the treatment of self-injurious behavior (SIB) in mentally retarded people have been equivocal. They have relied on small patient samples in short-term trials with varying degrees of scientific rigor. Nor has the clinical efficacy...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1996-10, Vol.16 (5), p.389-394 |
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| container_title | Journal of clinical psychopharmacology |
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| creator | CASNER, J. A WEINHEIMER, B GUALTIERI, C. T |
| description | The results of studies of the opiate antagonist naltrexone (NLTX) in the treatment of self-injurious behavior (SIB) in mentally retarded people have been equivocal. They have relied on small patient samples in short-term trials with varying degrees of scientific rigor. Nor has the clinical efficacy of NLTX for SIB been tested against its wider application in nonresearch settings. The present study is a retrospective, long-term study of the clinical use of NLTX for SIB, drawn from clinical experience in the entire population of the state schools of Texas (population = 8,000). More than 50% of the 56 SIB individuals treated with NLTX were maintained on the drug by virtue of clinical benefit perceived by treating professionals; 25% of the 56 individuals could be classified as unequivocal responders based upon strict objective response criteria. Variables associated with positive response were level of disability and lack of concurrent aggression. Unexpectedly, all of the objective responders displayed a gradual and continuous decrease in SIB over-time, even after 3 years of treatment. |
| doi_str_mv | 10.1097/00004714-199610000-00008 |
| format | Article |
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The present study is a retrospective, long-term study of the clinical use of NLTX for SIB, drawn from clinical experience in the entire population of the state schools of Texas (population = 8,000). More than 50% of the 56 SIB individuals treated with NLTX were maintained on the drug by virtue of clinical benefit perceived by treating professionals; 25% of the 56 individuals could be classified as unequivocal responders based upon strict objective response criteria. Variables associated with positive response were level of disability and lack of concurrent aggression. Unexpectedly, all of the objective responders displayed a gradual and continuous decrease in SIB over-time, even after 3 years of treatment.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8889912</pmid><doi>10.1097/00004714-199610000-00008</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0271-0749 |
| ispartof | Journal of clinical psychopharmacology, 1996-10, Vol.16 (5), p.389-394 |
| issn | 0271-0749 1533-712X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Female Humans Intellectual Disability - complications Male Medical sciences Miscellaneous Naltrexone - therapeutic use Narcotic Antagonists - therapeutic use Neuropharmacology Pharmacology. Drug treatments Retrospective Studies Self-Injurious Behavior - drug therapy Self-Injurious Behavior - etiology |
| title | Naltrexone and self-injurious behavior : A retrospective population study |
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