Effect of antioxidants on postoperative hyperamylasemia in Coronary bypass surgery
Antioxidants may reduce pancreatic cellular injury after coronary artery bypass grafting (CABG) Twenty patients (Group A) received vitamin E (600 mg/ day) for 28 days and vitamin C (2 g/day) and allopurinol (600 mg/day) 2 days before and 1 day after CABG. Seventeen patients (Group C) received all dr...
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| Veröffentlicht in: | Pancreas 1996-10, Vol.13 (3), p.236-240 |
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| container_title | Pancreas |
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| creator | PAAJANEN, H HARMOINEN, A SISTO, T TARKKA, M METSÄ-KETELÄ, T IOVANNA, J. L DAGORN, J.-C NORDBACK, I. H |
| description | Antioxidants may reduce pancreatic cellular injury after coronary artery bypass grafting (CABG) Twenty patients (Group A) received vitamin E (600 mg/ day) for 28 days and vitamin C (2 g/day) and allopurinol (600 mg/day) 2 days before and 1 day after CABG. Seventeen patients (Group C) received all drugs for 3 days, and 25 (Group B) and 19 (Group D) patients served as corresponding controls. The pre- and postoperative pancreatic isoamylase (P-amylase), creatinine, and antioxidant concentrations were measured. Serum hyperamylasemia was highest on the first postoperative day and occurred in 73% of the patients. After surgery serum P-amylase increased in all study groups and urine P-amylase decreased. Postoperative serum hyperamylasemia, whether primarily renal or pancreatic, cannot be decreased by pretreatment with allopurinol, vitamin C, and vitamin E. |
| doi_str_mv | 10.1097/00006676-199610000-00004 |
| format | Article |
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L ; DAGORN, J.-C ; NORDBACK, I. H</creator><creatorcontrib>PAAJANEN, H ; HARMOINEN, A ; SISTO, T ; TARKKA, M ; METSÄ-KETELÄ, T ; IOVANNA, J. L ; DAGORN, J.-C ; NORDBACK, I. H</creatorcontrib><description>Antioxidants may reduce pancreatic cellular injury after coronary artery bypass grafting (CABG) Twenty patients (Group A) received vitamin E (600 mg/ day) for 28 days and vitamin C (2 g/day) and allopurinol (600 mg/day) 2 days before and 1 day after CABG. Seventeen patients (Group C) received all drugs for 3 days, and 25 (Group B) and 19 (Group D) patients served as corresponding controls. The pre- and postoperative pancreatic isoamylase (P-amylase), creatinine, and antioxidant concentrations were measured. Serum hyperamylasemia was highest on the first postoperative day and occurred in 73% of the patients. After surgery serum P-amylase increased in all study groups and urine P-amylase decreased. Postoperative serum hyperamylasemia, whether primarily renal or pancreatic, cannot be decreased by pretreatment with allopurinol, vitamin C, and vitamin E.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-199610000-00004</identifier><identifier>PMID: 8884843</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Allopurinol - therapeutic use ; Amylases - blood ; Antioxidants - therapeutic use ; Ascorbic Acid - therapeutic use ; Biological and medical sciences ; Coronary Artery Bypass - adverse effects ; Creatinine - blood ; Digestive system ; Female ; Humans ; Isoenzymes - blood ; Male ; Medical sciences ; Middle Aged ; Pancreas - enzymology ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Prospective Studies ; Vitamin E - therapeutic use</subject><ispartof>Pancreas, 1996-10, Vol.13 (3), p.236-240</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-fc6a708f26096eaeed56d45a2d187ab9ac14b4810ea3fea40b18d95d20bb7b103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3224457$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8884843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PAAJANEN, H</creatorcontrib><creatorcontrib>HARMOINEN, A</creatorcontrib><creatorcontrib>SISTO, T</creatorcontrib><creatorcontrib>TARKKA, M</creatorcontrib><creatorcontrib>METSÄ-KETELÄ, T</creatorcontrib><creatorcontrib>IOVANNA, J. L</creatorcontrib><creatorcontrib>DAGORN, J.-C</creatorcontrib><creatorcontrib>NORDBACK, I. H</creatorcontrib><title>Effect of antioxidants on postoperative hyperamylasemia in Coronary bypass surgery</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>Antioxidants may reduce pancreatic cellular injury after coronary artery bypass grafting (CABG) Twenty patients (Group A) received vitamin E (600 mg/ day) for 28 days and vitamin C (2 g/day) and allopurinol (600 mg/day) 2 days before and 1 day after CABG. Seventeen patients (Group C) received all drugs for 3 days, and 25 (Group B) and 19 (Group D) patients served as corresponding controls. The pre- and postoperative pancreatic isoamylase (P-amylase), creatinine, and antioxidant concentrations were measured. Serum hyperamylasemia was highest on the first postoperative day and occurred in 73% of the patients. After surgery serum P-amylase increased in all study groups and urine P-amylase decreased. Postoperative serum hyperamylasemia, whether primarily renal or pancreatic, cannot be decreased by pretreatment with allopurinol, vitamin C, and vitamin E.</description><subject>Aged</subject><subject>Allopurinol - therapeutic use</subject><subject>Amylases - blood</subject><subject>Antioxidants - therapeutic use</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Creatinine - blood</subject><subject>Digestive system</subject><subject>Female</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pancreas - enzymology</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Prospective Studies</subject><subject>Vitamin E - therapeutic use</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1LxDAQDaKs6-pPEHIQb9WkSZP0KMv6AQuC6LlM2kQjbVOTVuy_t3XXncN8vjczPIQwJTeU5PKWTCaEFAnNc0HnKpkdP0JLmjGRcJWqY7QkSmUJo1KeorMYPwmhkmX5Ai2UUlxxtkQvG2tN2WNvMbS98z-ummLEvsWdj73vTIDefRv8Mc5pM9YQTeMAuxavffAthBHrsYMYcRzCuwnjOTqxUEdzsY8r9Ha_eV0_Jtvnh6f13TYpmVB9YksBkiibCpILA8ZUmah4BmlFlQSdQ0m55ooSA8wa4ERTVeVZlRKtpaaErdD1bm8X_NdgYl80LpamrqE1foiFVFwKpugEVDtgGXyMwdiiC66ZHi8oKWY5i385i4Ocfy0-US_3NwbdmOpA3Os3za_2c4gl1DZAW7p4gLE05TyT7BeRyH7K</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>PAAJANEN, H</creator><creator>HARMOINEN, A</creator><creator>SISTO, T</creator><creator>TARKKA, M</creator><creator>METSÄ-KETELÄ, T</creator><creator>IOVANNA, J. 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H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-fc6a708f26096eaeed56d45a2d187ab9ac14b4810ea3fea40b18d95d20bb7b103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Allopurinol - therapeutic use</topic><topic>Amylases - blood</topic><topic>Antioxidants - therapeutic use</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Creatinine - blood</topic><topic>Digestive system</topic><topic>Female</topic><topic>Humans</topic><topic>Isoenzymes - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pancreas - enzymology</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Prospective Studies</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAAJANEN, H</creatorcontrib><creatorcontrib>HARMOINEN, A</creatorcontrib><creatorcontrib>SISTO, T</creatorcontrib><creatorcontrib>TARKKA, M</creatorcontrib><creatorcontrib>METSÄ-KETELÄ, T</creatorcontrib><creatorcontrib>IOVANNA, J. L</creatorcontrib><creatorcontrib>DAGORN, J.-C</creatorcontrib><creatorcontrib>NORDBACK, I. 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H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of antioxidants on postoperative hyperamylasemia in Coronary bypass surgery</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>13</volume><issue>3</issue><spage>236</spage><epage>240</epage><pages>236-240</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>Antioxidants may reduce pancreatic cellular injury after coronary artery bypass grafting (CABG) Twenty patients (Group A) received vitamin E (600 mg/ day) for 28 days and vitamin C (2 g/day) and allopurinol (600 mg/day) 2 days before and 1 day after CABG. Seventeen patients (Group C) received all drugs for 3 days, and 25 (Group B) and 19 (Group D) patients served as corresponding controls. The pre- and postoperative pancreatic isoamylase (P-amylase), creatinine, and antioxidant concentrations were measured. Serum hyperamylasemia was highest on the first postoperative day and occurred in 73% of the patients. After surgery serum P-amylase increased in all study groups and urine P-amylase decreased. Postoperative serum hyperamylasemia, whether primarily renal or pancreatic, cannot be decreased by pretreatment with allopurinol, vitamin C, and vitamin E.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8884843</pmid><doi>10.1097/00006676-199610000-00004</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pancreas, 1996-10, Vol.13 (3), p.236-240 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Allopurinol - therapeutic use Amylases - blood Antioxidants - therapeutic use Ascorbic Acid - therapeutic use Biological and medical sciences Coronary Artery Bypass - adverse effects Creatinine - blood Digestive system Female Humans Isoenzymes - blood Male Medical sciences Middle Aged Pancreas - enzymology Pharmacology. Drug treatments Postoperative Complications - prevention & control Prospective Studies Vitamin E - therapeutic use |
| title | Effect of antioxidants on postoperative hyperamylasemia in Coronary bypass surgery |
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