Preparation and Antirheumatic Activity of Optically Active 2-Acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic Acid (KE-298)

2-Acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanonic acid (KE-298) is an antirheumatic agent. To elucidate the effects of optically active KE-298, we resolved the racemic acid and obtained the two optical isomers. (+)-KE-298 was converted to the 4-bromobenzyl ester derivative and the absolute struct...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1996/03/15, Vol.44(3), pp.602-604
Hauptverfasser:	KAMEO, Kazuya, TAKESHITA, Kimiyo, YASUDA, Yoshiko, MATSUMOTO, Keita, TOMISAWA, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanonic acid absolute stereochemistry Animals antirheumatic activity Antirheumatic Agents - chemical synthesis Antirheumatic Agents - chemistry Antirheumatic Agents - pharmacology Arthritis, Experimental - drug therapy Arthritis, Experimental - pathology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Crystallography, X-Ray Edema - drug therapy Edema - pathology Female In Vitro Techniques Interleukin-1 - antagonists & inhibitors Lipopolysaccharides Lymphocyte Activation - drug effects Medical sciences Mice Mice, Inbred C3H optical resolution Optical Rotation Pharmacology. Drug treatments Phenylpropionates - chemical synthesis Phenylpropionates - chemistry Phenylpropionates - pharmacology Rats Receptors, Interleukin-1 - biosynthesis Spectrophotometry, Infrared Stereoisomerism T-Lymphocytes - drug effects
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