The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor
The present study was designed to evaluate whether the neuroprotective efficacy of MK-801 in focal cerebral ischemia was dependent on strain and/or vendor differences. MK-801 (0.12 mg/kg i.v. bolus followed by 0.108 mg/kg/h infusion or 0.60 mg/kg i.v. bolus followed by 0.540 mg/kg/h infusion) or sal...
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| Veröffentlicht in: | Brain research 1996-08, Vol.731 (1), p.208-212 |
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| creator | Oliff, Heather S. Marek, Przemyslaw Miyazaki, Brian Weber, Eckard |
| description | The present study was designed to evaluate whether the neuroprotective efficacy of MK-801 in focal cerebral ischemia was dependent on strain and/or vendor differences. MK-801 (0.12 mg/kg i.v. bolus followed by 0.108 mg/kg/h infusion or 0.60 mg/kg i.v. bolus followed by 0.540 mg/kg/h infusion) or saline was administered just after intraluminal middle cerebral artery occlusion. Administration of 0.540 mg/kg/h MK-801 provided strain/line-dependent neuroprotection in the following rank order: Simonsen Laboratories Sprague-Dawley rats > Simonsen Laboratories Wistar rats > Taconic Laboratories Sprague-Dawley rats. After 0.108 mg/kg/h MK-801 treatment, Simonsen Laboratories Wistar rats were the only strain/line that were significantly neuroprotected. These results indicate that the neuroprotective effect of an experimental drug may be influenced by rat strain and vendor differences. |
| doi_str_mv | 10.1016/0006-8993(96)00582-3 |
| format | Article |
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MK-801 (0.12 mg/kg i.v. bolus followed by 0.108 mg/kg/h infusion or 0.60 mg/kg i.v. bolus followed by 0.540 mg/kg/h infusion) or saline was administered just after intraluminal middle cerebral artery occlusion. Administration of 0.540 mg/kg/h MK-801 provided strain/line-dependent neuroprotection in the following rank order: Simonsen Laboratories Sprague-Dawley rats > Simonsen Laboratories Wistar rats > Taconic Laboratories Sprague-Dawley rats. After 0.108 mg/kg/h MK-801 treatment, Simonsen Laboratories Wistar rats were the only strain/line that were significantly neuroprotected. 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All rights reserved</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-d1bfcd825393e462217e636bb3cf47acf08805e54a7b28d29d17392bf428d4603</citedby><cites>FETCH-LOGICAL-c332t-d1bfcd825393e462217e636bb3cf47acf08805e54a7b28d29d17392bf428d4603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(96)00582-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3205770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8883872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliff, Heather S.</creatorcontrib><creatorcontrib>Marek, Przemyslaw</creatorcontrib><creatorcontrib>Miyazaki, Brian</creatorcontrib><creatorcontrib>Weber, Eckard</creatorcontrib><title>The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The present study was designed to evaluate whether the neuroprotective efficacy of MK-801 in focal cerebral ischemia was dependent on strain and/or vendor differences. MK-801 (0.12 mg/kg i.v. bolus followed by 0.108 mg/kg/h infusion or 0.60 mg/kg i.v. bolus followed by 0.540 mg/kg/h infusion) or saline was administered just after intraluminal middle cerebral artery occlusion. Administration of 0.540 mg/kg/h MK-801 provided strain/line-dependent neuroprotection in the following rank order: Simonsen Laboratories Sprague-Dawley rats > Simonsen Laboratories Wistar rats > Taconic Laboratories Sprague-Dawley rats. After 0.108 mg/kg/h MK-801 treatment, Simonsen Laboratories Wistar rats were the only strain/line that were significantly neuroprotected. These results indicate that the neuroprotective effect of an experimental drug may be influenced by rat strain and vendor differences.</description><subject>Animals</subject><subject>Animals, Laboratory</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Brain Ischemia - drug therapy</subject><subject>Cerebral Arteries - surgery</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Filament</subject><subject>Focal cerebral ischemia</subject><subject>Intraluminal thread</subject><subject>Ligation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MK-801</subject><subject>Neurology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>Strain difference</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLLDEQhYMo3vHxD7yQhYguWvPozmMjiPhCxY2uQzqpMJGZbm_SMzL_3jQzzPK6Sg71VVF1DkInlFxSQsUVIURUSmt-rsUFIY1iFd9BE6okqwSryS6abJE_6CDnzyI512Qf7SuleOEmyL1PAXewSP1X6gdwQ1wChhCis26F-4BfnytFKI4dDr2zM-wgQZvKJ2Y3hXm0eGlThIy_4zDFyQ44D8kW3HYeL6HzfTpCe8HOMhxv3kP0cX_3fvtYvbw9PN3evFSOczZUnrbBecUarjnUgjEqQXDRttyFWloXiFKkgaa2smXKM-2p5Jq1oS6qFoQforP13HLKvwXkwczLkjCb2Q76RTZS1ZILLX8FaSMaRgUvYL0GXepzThDMV4pzm1aGEjOGYEaHzeiw0aMoIZix7e9m_qKdg982bVwv9dNN3ebiaUi2czFvMc5II-V4z_Uag2LaMkIy2UXoHPiYSlLG9_H_e_wAwZShwQ</recordid><startdate>19960826</startdate><enddate>19960826</enddate><creator>Oliff, Heather S.</creator><creator>Marek, Przemyslaw</creator><creator>Miyazaki, Brian</creator><creator>Weber, Eckard</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19960826</creationdate><title>The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor</title><author>Oliff, Heather S. ; Marek, Przemyslaw ; Miyazaki, Brian ; Weber, Eckard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-d1bfcd825393e462217e636bb3cf47acf08805e54a7b28d29d17392bf428d4603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Animals, Laboratory</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Brain Ischemia - drug therapy</topic><topic>Cerebral Arteries - surgery</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Filament</topic><topic>Focal cerebral ischemia</topic><topic>Intraluminal thread</topic><topic>Ligation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MK-801</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>Strain difference</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliff, Heather S.</creatorcontrib><creatorcontrib>Marek, Przemyslaw</creatorcontrib><creatorcontrib>Miyazaki, Brian</creatorcontrib><creatorcontrib>Weber, Eckard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliff, Heather S.</au><au>Marek, Przemyslaw</au><au>Miyazaki, Brian</au><au>Weber, Eckard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1996-08-26</date><risdate>1996</risdate><volume>731</volume><issue>1</issue><spage>208</spage><epage>212</epage><pages>208-212</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The present study was designed to evaluate whether the neuroprotective efficacy of MK-801 in focal cerebral ischemia was dependent on strain and/or vendor differences. MK-801 (0.12 mg/kg i.v. bolus followed by 0.108 mg/kg/h infusion or 0.60 mg/kg i.v. bolus followed by 0.540 mg/kg/h infusion) or saline was administered just after intraluminal middle cerebral artery occlusion. Administration of 0.540 mg/kg/h MK-801 provided strain/line-dependent neuroprotection in the following rank order: Simonsen Laboratories Sprague-Dawley rats > Simonsen Laboratories Wistar rats > Taconic Laboratories Sprague-Dawley rats. After 0.108 mg/kg/h MK-801 treatment, Simonsen Laboratories Wistar rats were the only strain/line that were significantly neuroprotected. These results indicate that the neuroprotective effect of an experimental drug may be influenced by rat strain and vendor differences.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8883872</pmid><doi>10.1016/0006-8993(96)00582-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 1996-08, Vol.731 (1), p.208-212 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Animals, Laboratory Biological and medical sciences Body Temperature - drug effects Brain Ischemia - drug therapy Cerebral Arteries - surgery Cerebral Cortex - blood supply Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Filament Focal cerebral ischemia Intraluminal thread Ligation Male Medical sciences MK-801 Neurology Neuroprotective Agents - pharmacology Rat Rats Rats, Sprague-Dawley Rats, Wistar Strain difference Vascular diseases and vascular malformations of the nervous system |
| title | The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor |
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