Lateral tegmental field neurons sensitive to muscular contraction: A role in pressor reflexes?
The medullary lateral tegmental field (LTF) has a major role in sympathetic nerve discharge (SND) rhythmicity, but its role in pressor reflexes generated by hindlimb muscular contraction (MC) is unknown. Therefore, two sets of experiments were performed in 17 chloralose-urethane anesthetized cats. F...
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| Veröffentlicht in: | Brain research bulletin 1996, Vol.41 (2), p.111-120 |
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| description | The medullary lateral tegmental field (LTF) has a major role in sympathetic nerve discharge (SND) rhythmicity, but its role in pressor reflexes generated by hindlimb muscular contraction (MC) is unknown. Therefore, two sets of experiments were performed in 17 chloralose-urethane anesthetized cats. First, response of single LTF neurons to MC induced by L7-S1 ventral root stimulation were examined. The majority (30 of 47) of LTF neurons increased firing during MC. Most LTF neurons had a basal discharge correlated with the 2–10 Hz rhythm of SND or the cardiac cycle and responded to increases in blood pressure. Only seven neurons were inhibited by MC, most having a respiratory rhythm. Second, pressor responses to MC and to caudal hypothalamic stimulation were examined before and after bilateral LTF microinjections of a synaptic blocker (CoCl
2) as well as with lidocaine. Microinjection of CoCl
2 or lidocaine significantly attenuating the dominant 2–10 Hz power coefficient of SND had no effect on the pressor responses to MC or caudal hypothalamic stimulation. Therefore, LTF may be important for basal rhythms in SND and may help synchronize SND during MC, but its contribution to basal rhythms is apparently not required for pressor reflexes evoked by hindlimb MC or hypothalamic stimulation. |
| doi_str_mv | 10.1016/0361-9230(96)00157-8 |
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2) as well as with lidocaine. Microinjection of CoCl
2 or lidocaine significantly attenuating the dominant 2–10 Hz power coefficient of SND had no effect on the pressor responses to MC or caudal hypothalamic stimulation. Therefore, LTF may be important for basal rhythms in SND and may help synchronize SND during MC, but its contribution to basal rhythms is apparently not required for pressor reflexes evoked by hindlimb MC or hypothalamic stimulation.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(96)00157-8</identifier><identifier>PMID: 8879675</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenergic alpha-Agonists - administration & dosage ; Adrenergic alpha-Agonists - pharmacology ; Animals ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Cat ; Cats ; Central Nervous System Depressants - pharmacology ; Cobalt - pharmacology ; Electric Stimulation ; Exercise ; Fundamental and applied biological sciences. Psychology ; Hypothalamus ; Hypothalamus, Posterior - physiology ; Lidocaine - pharmacology ; Medulla ; Microinjections ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Muscle Contraction - physiology ; Neurons - physiology ; Phenylephrine - administration & dosage ; Phenylephrine - pharmacology ; Pressoreceptors - drug effects ; Pressoreceptors - physiology ; Respiratory Mechanics - drug effects ; Respiratory Mechanics - physiology ; Respiratory Muscles - drug effects ; Respiratory Muscles - innervation ; Respiratory Muscles - physiology ; Sympathetic Nervous System - cytology ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology ; Tegmentum Mesencephali - anatomy & histology ; Tegmentum Mesencephali - cytology ; Tegmentum Mesencephali - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research bulletin, 1996, Vol.41 (2), p.111-120</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-f6330519662dd786f2d43b9b407b3888eda7c64a91abfa4c676edd143d019a0a3</citedby><cites>FETCH-LOGICAL-c349t-f6330519662dd786f2d43b9b407b3888eda7c64a91abfa4c676edd143d019a0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(96)00157-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3228097$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8879675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwamoto, Gary A.</creatorcontrib><creatorcontrib>Waldrop, Tony G.</creatorcontrib><title>Lateral tegmental field neurons sensitive to muscular contraction: A role in pressor reflexes?</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>The medullary lateral tegmental field (LTF) has a major role in sympathetic nerve discharge (SND) rhythmicity, but its role in pressor reflexes generated by hindlimb muscular contraction (MC) is unknown. Therefore, two sets of experiments were performed in 17 chloralose-urethane anesthetized cats. First, response of single LTF neurons to MC induced by L7-S1 ventral root stimulation were examined. The majority (30 of 47) of LTF neurons increased firing during MC. Most LTF neurons had a basal discharge correlated with the 2–10 Hz rhythm of SND or the cardiac cycle and responded to increases in blood pressure. Only seven neurons were inhibited by MC, most having a respiratory rhythm. Second, pressor responses to MC and to caudal hypothalamic stimulation were examined before and after bilateral LTF microinjections of a synaptic blocker (CoCl
2) as well as with lidocaine. Microinjection of CoCl
2 or lidocaine significantly attenuating the dominant 2–10 Hz power coefficient of SND had no effect on the pressor responses to MC or caudal hypothalamic stimulation. Therefore, LTF may be important for basal rhythms in SND and may help synchronize SND during MC, but its contribution to basal rhythms is apparently not required for pressor reflexes evoked by hindlimb MC or hypothalamic stimulation.</description><subject>Adrenergic alpha-Agonists - administration & dosage</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cat</subject><subject>Cats</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Cobalt - pharmacology</subject><subject>Electric Stimulation</subject><subject>Exercise</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus</subject><subject>Hypothalamus, Posterior - physiology</subject><subject>Lidocaine - pharmacology</subject><subject>Medulla</subject><subject>Microinjections</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Muscle Contraction - physiology</subject><subject>Neurons - physiology</subject><subject>Phenylephrine - administration & dosage</subject><subject>Phenylephrine - pharmacology</subject><subject>Pressoreceptors - drug effects</subject><subject>Pressoreceptors - physiology</subject><subject>Respiratory Mechanics - drug effects</subject><subject>Respiratory Mechanics - physiology</subject><subject>Respiratory Muscles - drug effects</subject><subject>Respiratory Muscles - innervation</subject><subject>Respiratory Muscles - physiology</subject><subject>Sympathetic Nervous System - cytology</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Tegmentum Mesencephali - anatomy & histology</subject><subject>Tegmentum Mesencephali - cytology</subject><subject>Tegmentum Mesencephali - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQQIMo6-yu_0AhB5H10G7SSedjD8qyqLsw4EWvhnRSLZHuZEzSi_57M8wwRz1VFfWqqHoIvaTkHSVUXBMmaKd7Rq60eEsIHWSnnqANVZJ1veTyKdqckOfovJSfhBChBnGGzpSSWshhg75vbYVsZ1zhxwKxtmwKMHscYc0pFlwgllDDI-Ca8LIWt842Y5dizdbVkOINvsU5zYBDxLsMpaSMM0wz_Iby4RI9m-xc4MUxXqBvnz5-vbvvtl8-P9zdbjvHuK7dJBgjA9VC9N5LJabeczbqkRM5MqUUeCud4FZTO06WOyEFeE8584RqSyy7QG8Oe3c5_VqhVLOE4mCebYS0FiMVl70k5L8gHYRqt_QN5AfQ5VRKe8jsclhs_mMoMXv_Zi_X7OUa3Yq9f6Pa2Kvj_nVcwJ-GjsJb__Wxb4uz85RtdKGcMNb3imjZsPcHDJq0xwDZFBcgOvAhg6vGp_DvO_4CzwKhqA</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Iwamoto, Gary A.</creator><creator>Waldrop, Tony G.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Lateral tegmental field neurons sensitive to muscular contraction: A role in pressor reflexes?</title><author>Iwamoto, Gary A. ; Waldrop, Tony G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-f6330519662dd786f2d43b9b407b3888eda7c64a91abfa4c676edd143d019a0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenergic alpha-Agonists - administration & dosage</topic><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cat</topic><topic>Cats</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Cobalt - pharmacology</topic><topic>Electric Stimulation</topic><topic>Exercise</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus</topic><topic>Hypothalamus, Posterior - physiology</topic><topic>Lidocaine - pharmacology</topic><topic>Medulla</topic><topic>Microinjections</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Muscle Contraction - physiology</topic><topic>Neurons - physiology</topic><topic>Phenylephrine - administration & dosage</topic><topic>Phenylephrine - pharmacology</topic><topic>Pressoreceptors - drug effects</topic><topic>Pressoreceptors - physiology</topic><topic>Respiratory Mechanics - drug effects</topic><topic>Respiratory Mechanics - physiology</topic><topic>Respiratory Muscles - drug effects</topic><topic>Respiratory Muscles - innervation</topic><topic>Respiratory Muscles - physiology</topic><topic>Sympathetic Nervous System - cytology</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Tegmentum Mesencephali - anatomy & histology</topic><topic>Tegmentum Mesencephali - cytology</topic><topic>Tegmentum Mesencephali - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwamoto, Gary A.</creatorcontrib><creatorcontrib>Waldrop, Tony G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwamoto, Gary A.</au><au>Waldrop, Tony G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lateral tegmental field neurons sensitive to muscular contraction: A role in pressor reflexes?</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1996</date><risdate>1996</risdate><volume>41</volume><issue>2</issue><spage>111</spage><epage>120</epage><pages>111-120</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The medullary lateral tegmental field (LTF) has a major role in sympathetic nerve discharge (SND) rhythmicity, but its role in pressor reflexes generated by hindlimb muscular contraction (MC) is unknown. Therefore, two sets of experiments were performed in 17 chloralose-urethane anesthetized cats. First, response of single LTF neurons to MC induced by L7-S1 ventral root stimulation were examined. The majority (30 of 47) of LTF neurons increased firing during MC. Most LTF neurons had a basal discharge correlated with the 2–10 Hz rhythm of SND or the cardiac cycle and responded to increases in blood pressure. Only seven neurons were inhibited by MC, most having a respiratory rhythm. Second, pressor responses to MC and to caudal hypothalamic stimulation were examined before and after bilateral LTF microinjections of a synaptic blocker (CoCl
2) as well as with lidocaine. Microinjection of CoCl
2 or lidocaine significantly attenuating the dominant 2–10 Hz power coefficient of SND had no effect on the pressor responses to MC or caudal hypothalamic stimulation. Therefore, LTF may be important for basal rhythms in SND and may help synchronize SND during MC, but its contribution to basal rhythms is apparently not required for pressor reflexes evoked by hindlimb MC or hypothalamic stimulation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8879675</pmid><doi>10.1016/0361-9230(96)00157-8</doi><tpages>10</tpages></addata></record> |
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| subjects | Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Animals Biological and medical sciences Blood pressure Blood Pressure - drug effects Cat Cats Central Nervous System Depressants - pharmacology Cobalt - pharmacology Electric Stimulation Exercise Fundamental and applied biological sciences. Psychology Hypothalamus Hypothalamus, Posterior - physiology Lidocaine - pharmacology Medulla Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Muscle Contraction - physiology Neurons - physiology Phenylephrine - administration & dosage Phenylephrine - pharmacology Pressoreceptors - drug effects Pressoreceptors - physiology Respiratory Mechanics - drug effects Respiratory Mechanics - physiology Respiratory Muscles - drug effects Respiratory Muscles - innervation Respiratory Muscles - physiology Sympathetic Nervous System - cytology Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Tegmentum Mesencephali - anatomy & histology Tegmentum Mesencephali - cytology Tegmentum Mesencephali - physiology Vertebrates: nervous system and sense organs |
| title | Lateral tegmental field neurons sensitive to muscular contraction: A role in pressor reflexes? |
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