Serum laminin and basic fibroblast growth factor concentrations in patients with complicated Plasmodium falciparum malaria
Serum concentrations of laminin and basic fibroblast growth factor (FGF) were measured in 20 patients suffering from complicated Plasmodium falciparum malaria in Bangkok. Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting...
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| Veröffentlicht in: | Journal of clinical immunology 1996-09, Vol.16 (5), p.278-282 |
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| container_end_page | 282 |
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| container_issue | 5 |
| container_start_page | 278 |
| container_title | Journal of clinical immunology |
| container_volume | 16 |
| creator | BURGMANN, H LOOAREESUWAN, S VIRAVAN, C VANIJANONTA, S ZEDWITZ-LIEBENSTEIN, K VORBACH, H GRANINGER, W |
| description | Serum concentrations of laminin and basic fibroblast growth factor (FGF) were measured in 20 patients suffering from complicated Plasmodium falciparum malaria in Bangkok. Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting medication (1025 ng/ml) in comparison to the control (412 ng/ml). The values remained numerically higher for at least 21 days. With regard to serum basic FGF concentrations, a peak was found 7 day after starting treatment (35.61 pg/ml). In addition, a significant correlation was found for parasite clearance time and basic FGF concentration on day 7 (P < 0.01). These increased values of laminin and basic FGF may be the consequence of endothelial and basement membrane damage induced by sequestration of the parasites. Furthermore, basic FGF might play a role in endothelial repair mechanisms after the clearance of the parasites. |
| doi_str_mv | 10.1007/BF01541393 |
| format | Article |
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Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting medication (1025 ng/ml) in comparison to the control (412 ng/ml). The values remained numerically higher for at least 21 days. With regard to serum basic FGF concentrations, a peak was found 7 day after starting treatment (35.61 pg/ml). In addition, a significant correlation was found for parasite clearance time and basic FGF concentration on day 7 (P < 0.01). These increased values of laminin and basic FGF may be the consequence of endothelial and basement membrane damage induced by sequestration of the parasites. Furthermore, basic FGF might play a role in endothelial repair mechanisms after the clearance of the parasites.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>DOI: 10.1007/BF01541393</identifier><identifier>PMID: 8886997</identifier><identifier>CODEN: JCIMDO</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Adolescent ; Adult ; Aged ; Antimalarials - therapeutic use ; Artemisinins ; Biological and medical sciences ; Fibroblast Growth Factor 2 - blood ; Human protozoal diseases ; Humans ; Infectious diseases ; Kinetics ; Laminin - blood ; Malaria ; Malaria, Falciparum - drug therapy ; Malaria, Falciparum - immunology ; Malaria, Falciparum - pathology ; Medical sciences ; Mefloquine - therapeutic use ; Middle Aged ; Parasitic diseases ; Protozoal diseases ; Sesquiterpenes - therapeutic use</subject><ispartof>Journal of clinical immunology, 1996-09, Vol.16 (5), p.278-282</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3217484$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8886997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BURGMANN, H</creatorcontrib><creatorcontrib>LOOAREESUWAN, S</creatorcontrib><creatorcontrib>VIRAVAN, C</creatorcontrib><creatorcontrib>VANIJANONTA, S</creatorcontrib><creatorcontrib>ZEDWITZ-LIEBENSTEIN, K</creatorcontrib><creatorcontrib>VORBACH, H</creatorcontrib><creatorcontrib>GRANINGER, W</creatorcontrib><title>Serum laminin and basic fibroblast growth factor concentrations in patients with complicated Plasmodium falciparum malaria</title><title>Journal of clinical immunology</title><addtitle>J Clin Immunol</addtitle><description>Serum concentrations of laminin and basic fibroblast growth factor (FGF) were measured in 20 patients suffering from complicated Plasmodium falciparum malaria in Bangkok. Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting medication (1025 ng/ml) in comparison to the control (412 ng/ml). The values remained numerically higher for at least 21 days. With regard to serum basic FGF concentrations, a peak was found 7 day after starting treatment (35.61 pg/ml). In addition, a significant correlation was found for parasite clearance time and basic FGF concentration on day 7 (P < 0.01). These increased values of laminin and basic FGF may be the consequence of endothelial and basement membrane damage induced by sequestration of the parasites. Furthermore, basic FGF might play a role in endothelial repair mechanisms after the clearance of the parasites.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antimalarials - therapeutic use</subject><subject>Artemisinins</subject><subject>Biological and medical sciences</subject><subject>Fibroblast Growth Factor 2 - blood</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Kinetics</subject><subject>Laminin - blood</subject><subject>Malaria</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - pathology</subject><subject>Medical sciences</subject><subject>Mefloquine - therapeutic use</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Sesquiterpenes - therapeutic use</subject><issn>0271-9142</issn><issn>1573-2592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LxDAQxYMo67p68S7kIN6q-U561MVVYUFBPS_TNNVI29SkZdG_3oiLpxne-715MAidUnJJCdFXNytCpaC85HtoTqXmBZMl20dzwjQtSirYITpK6YMQwhWTMzQzxqiy1HP0_ezi1OEWOt_7HkNf4wqSt7jxVQxVC2nEbzFsx3fcgB1DxDb01vVjhNGHPuEcGvKalYS3PmM2dEPrLYyuxk8534Xa54YGWusH-C3roIXo4RgdZDG5k91coNfV7cvyvlg_3j0sr9fFwLgcC22JKZWWoDln2pkSDFVOCuBGN6TmvGSVFY1QlVMKeJ0BXkkFRDSV5KLhC3Txd3eI4XNyadx0PlnXttC7MKWNNkIzJWQGz3bgVHWu3gzRdxC_NrtnZf9850Oy0DYReuvTP8YZ1cII_gOWeHnE</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>BURGMANN, H</creator><creator>LOOAREESUWAN, S</creator><creator>VIRAVAN, C</creator><creator>VANIJANONTA, S</creator><creator>ZEDWITZ-LIEBENSTEIN, K</creator><creator>VORBACH, H</creator><creator>GRANINGER, W</creator><general>Kluwer/Plenum</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19960901</creationdate><title>Serum laminin and basic fibroblast growth factor concentrations in patients with complicated Plasmodium falciparum malaria</title><author>BURGMANN, H ; LOOAREESUWAN, S ; VIRAVAN, C ; VANIJANONTA, S ; ZEDWITZ-LIEBENSTEIN, K ; VORBACH, H ; GRANINGER, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-7c089675a73327e89a816e54a387f0d3392bc4f46be66a3d89a3b56a04fb534f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antimalarials - therapeutic use</topic><topic>Artemisinins</topic><topic>Biological and medical sciences</topic><topic>Fibroblast Growth Factor 2 - blood</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Kinetics</topic><topic>Laminin - blood</topic><topic>Malaria</topic><topic>Malaria, Falciparum - drug therapy</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - pathology</topic><topic>Medical sciences</topic><topic>Mefloquine - therapeutic use</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Sesquiterpenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURGMANN, H</creatorcontrib><creatorcontrib>LOOAREESUWAN, S</creatorcontrib><creatorcontrib>VIRAVAN, C</creatorcontrib><creatorcontrib>VANIJANONTA, S</creatorcontrib><creatorcontrib>ZEDWITZ-LIEBENSTEIN, K</creatorcontrib><creatorcontrib>VORBACH, H</creatorcontrib><creatorcontrib>GRANINGER, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURGMANN, H</au><au>LOOAREESUWAN, S</au><au>VIRAVAN, C</au><au>VANIJANONTA, S</au><au>ZEDWITZ-LIEBENSTEIN, K</au><au>VORBACH, H</au><au>GRANINGER, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum laminin and basic fibroblast growth factor concentrations in patients with complicated Plasmodium falciparum malaria</atitle><jtitle>Journal of clinical immunology</jtitle><addtitle>J Clin Immunol</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>16</volume><issue>5</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>0271-9142</issn><eissn>1573-2592</eissn><coden>JCIMDO</coden><abstract>Serum concentrations of laminin and basic fibroblast growth factor (FGF) were measured in 20 patients suffering from complicated Plasmodium falciparum malaria in Bangkok. Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting medication (1025 ng/ml) in comparison to the control (412 ng/ml). The values remained numerically higher for at least 21 days. With regard to serum basic FGF concentrations, a peak was found 7 day after starting treatment (35.61 pg/ml). In addition, a significant correlation was found for parasite clearance time and basic FGF concentration on day 7 (P < 0.01). These increased values of laminin and basic FGF may be the consequence of endothelial and basement membrane damage induced by sequestration of the parasites. Furthermore, basic FGF might play a role in endothelial repair mechanisms after the clearance of the parasites.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>8886997</pmid><doi>10.1007/BF01541393</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-9142 |
| ispartof | Journal of clinical immunology, 1996-09, Vol.16 (5), p.278-282 |
| issn | 0271-9142 1573-2592 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adolescent Adult Aged Antimalarials - therapeutic use Artemisinins Biological and medical sciences Fibroblast Growth Factor 2 - blood Human protozoal diseases Humans Infectious diseases Kinetics Laminin - blood Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - immunology Malaria, Falciparum - pathology Medical sciences Mefloquine - therapeutic use Middle Aged Parasitic diseases Protozoal diseases Sesquiterpenes - therapeutic use |
| title | Serum laminin and basic fibroblast growth factor concentrations in patients with complicated Plasmodium falciparum malaria |
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