DNA index by image analysis in advanced endometrial carcinoma
Background Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease. Methods Twenty...
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| Veröffentlicht in: | Journal of surgical oncology 1996-10, Vol.63 (2), p.91-94 |
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| creator | Geisler, John P. Wiemann, Michael C. Zhou, Zhen Miller, Greg A. Geisler, Hans E. |
| description | Background
Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease.
Methods
Twenty consecutive patients, surgically treated, with advanced endometrial cancer, were evaluated for their DNA index (DI), time to recurrence, peritoneal cytology, depth of invasion, lymphovascular space invasion, as well as FIGO stage, grade, and histology. DI was determined using image analysis.
Results
Ten of the 20 patients had recurrence of their disease within the 3‐year observation period of the study. A DI of ≥ 1.2 strongly predicted recurrence of disease (P = 0.002). Increasing histologic grade and an increasing DI were related (P = 0.01).
Conclusion
Independent of other prognostic indicators, including lymphovascular space invasion, depth of invasion, and histologic type, a tumor with a DI of ≥ 1.2, had a significantly increased chance of recurring within the 3‐year observation period. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3.0.CO;2-J |
| format | Article |
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Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease.
Methods
Twenty consecutive patients, surgically treated, with advanced endometrial cancer, were evaluated for their DNA index (DI), time to recurrence, peritoneal cytology, depth of invasion, lymphovascular space invasion, as well as FIGO stage, grade, and histology. DI was determined using image analysis.
Results
Ten of the 20 patients had recurrence of their disease within the 3‐year observation period of the study. A DI of ≥ 1.2 strongly predicted recurrence of disease (P = 0.002). Increasing histologic grade and an increasing DI were related (P = 0.01).
Conclusion
Independent of other prognostic indicators, including lymphovascular space invasion, depth of invasion, and histologic type, a tumor with a DI of ≥ 1.2, had a significantly increased chance of recurring within the 3‐year observation period. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3.0.CO;2-J</identifier><identifier>PMID: 8888800</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma - genetics ; Carcinoma - pathology ; DNA index ; DNA, Neoplasm - analysis ; endometrial carcinoma ; Endometrial Neoplasms - genetics ; Endometrial Neoplasms - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; recurrence ; Risk Factors ; Tumors</subject><ispartof>Journal of surgical oncology, 1996-10, Vol.63 (2), p.91-94</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4574-2e7aa05dbbf9cdd2dec13d0fdffb756a00a2dc991e21cca1f256c402f92871d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9098%28199610%2963%3A2%3C91%3A%3AAID-JSO4%3E3.0.CO%3B2-J$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9098%28199610%2963%3A2%3C91%3A%3AAID-JSO4%3E3.0.CO%3B2-J$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2477220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8888800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geisler, John P.</creatorcontrib><creatorcontrib>Wiemann, Michael C.</creatorcontrib><creatorcontrib>Zhou, Zhen</creatorcontrib><creatorcontrib>Miller, Greg A.</creatorcontrib><creatorcontrib>Geisler, Hans E.</creatorcontrib><title>DNA index by image analysis in advanced endometrial carcinoma</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease.
Methods
Twenty consecutive patients, surgically treated, with advanced endometrial cancer, were evaluated for their DNA index (DI), time to recurrence, peritoneal cytology, depth of invasion, lymphovascular space invasion, as well as FIGO stage, grade, and histology. DI was determined using image analysis.
Results
Ten of the 20 patients had recurrence of their disease within the 3‐year observation period of the study. A DI of ≥ 1.2 strongly predicted recurrence of disease (P = 0.002). Increasing histologic grade and an increasing DI were related (P = 0.01).
Conclusion
Independent of other prognostic indicators, including lymphovascular space invasion, depth of invasion, and histologic type, a tumor with a DI of ≥ 1.2, had a significantly increased chance of recurring within the 3‐year observation period. © 1996 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - pathology</subject><subject>DNA index</subject><subject>DNA, Neoplasm - analysis</subject><subject>endometrial carcinoma</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>recurrence</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1v0zAUhi3ENMrgJyDlArHtIuXYcey4G0hVBqNVWS8KQuLmyLEdFMjHiFtY__0cWlVIoPnG8vGrx68fQi4ojCkAe322muWzcwpKxApUdkaVEhTORTJhl4pOJtPZVTxfLfnbZAzjfHnB4vkjMjrkH5NRoLCYSwVPyFPvvwNAQPBjcpwNC2BE3lzdTKOqte4uKrZR1ehvLtKtrre-8mEeaftLt8bZyLW2a9y6r3QdGd2bqu0a_Ywclbr27vl-PyGf37_7lH-IF8vrWT5dxIanksfMSa0htUVRKmMts87QxEJpy7KQqdAAmlmjFHWMGqNpyVJhOLBSsUxSmyQn5NWOe9t3PzfOr7GpvHF1rVvXbTzKjEuaChGCpw8HU55JJVIIydUuafrO-96VeNuH7_dbpICDfsRBPw46cdCJO_0oEmSoKGLQj4N-TBAwX4bpPFBf7N_fFI2zB-bed7h_ub_X3ui67IPcyh9ijEvJ2F_lfle12_7T7OFi_-n15xyo8Y5a-bW7O1B1_wOFTGSKX26u8eOCK8rTHL8m98-Pumg</recordid><startdate>199610</startdate><enddate>199610</enddate><creator>Geisler, John P.</creator><creator>Wiemann, Michael C.</creator><creator>Zhou, Zhen</creator><creator>Miller, Greg A.</creator><creator>Geisler, Hans E.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>199610</creationdate><title>DNA index by image analysis in advanced endometrial carcinoma</title><author>Geisler, John P. ; Wiemann, Michael C. ; Zhou, Zhen ; Miller, Greg A. ; Geisler, Hans E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-2e7aa05dbbf9cdd2dec13d0fdffb756a00a2dc991e21cca1f256c402f92871d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - pathology</topic><topic>DNA index</topic><topic>DNA, Neoplasm - analysis</topic><topic>endometrial carcinoma</topic><topic>Endometrial Neoplasms - genetics</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>recurrence</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geisler, John P.</creatorcontrib><creatorcontrib>Wiemann, Michael C.</creatorcontrib><creatorcontrib>Zhou, Zhen</creatorcontrib><creatorcontrib>Miller, Greg A.</creatorcontrib><creatorcontrib>Geisler, Hans E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geisler, John P.</au><au>Wiemann, Michael C.</au><au>Zhou, Zhen</au><au>Miller, Greg A.</au><au>Geisler, Hans E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA index by image analysis in advanced endometrial carcinoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1996-10</date><risdate>1996</risdate><volume>63</volume><issue>2</issue><spage>91</spage><epage>94</epage><pages>91-94</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>Background
Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease.
Methods
Twenty consecutive patients, surgically treated, with advanced endometrial cancer, were evaluated for their DNA index (DI), time to recurrence, peritoneal cytology, depth of invasion, lymphovascular space invasion, as well as FIGO stage, grade, and histology. DI was determined using image analysis.
Results
Ten of the 20 patients had recurrence of their disease within the 3‐year observation period of the study. A DI of ≥ 1.2 strongly predicted recurrence of disease (P = 0.002). Increasing histologic grade and an increasing DI were related (P = 0.01).
Conclusion
Independent of other prognostic indicators, including lymphovascular space invasion, depth of invasion, and histologic type, a tumor with a DI of ≥ 1.2, had a significantly increased chance of recurring within the 3‐year observation period. © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8888800</pmid><doi>10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3.0.CO;2-J</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Carcinoma - genetics Carcinoma - pathology DNA index DNA, Neoplasm - analysis endometrial carcinoma Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Staging Predictive Value of Tests Prognosis recurrence Risk Factors Tumors |
| title | DNA index by image analysis in advanced endometrial carcinoma |
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