Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems
Mice were trained in one-way active avoidance to a criterion of 3 4 avoidances and tested under extinction conditions one week later when substantial forgetting had occurred. Thirty min prior to testing animals were injected with either saline or different doses of drugs which activate the noradrene...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1988-05, Vol.30 (1), p.77-81 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Quartermain, David Judge, Martin E. Leo, Paul |
| description | Mice were trained in one-way active avoidance to a criterion of
3
4
avoidances and tested under extinction conditions one week later when substantial forgetting had occurred. Thirty min prior to testing animals were injected with either saline or different doses of drugs which activate the noradrenergic (phenylephrine, salbutamol, clonidine) dopaminergic (L-dopa(Sinemet) transdihydrolisuride, apomorphine) and serotonergic (fluoxetine, 5-methoxy DMT) neurotransmitter systems. Results showed that all agents alleviated forgetting in a dose dependent fashion. Untrained mice treated with the most effective dose of representative drugs from each class did not exhibit avoidance behavior at testing indicating that the improved performance of trained animals was probably not the result of increased activity or other non-memorial effects of the drugs. It was concluded that pharmacological agents which stimulate monoamine systems may improve memory retrieval by activating a non-specific neural system which controls arousal, attention and motor readiness. |
| doi_str_mv | 10.1016/0091-3057(88)90427-3 |
| format | Article |
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3
4
avoidances and tested under extinction conditions one week later when substantial forgetting had occurred. Thirty min prior to testing animals were injected with either saline or different doses of drugs which activate the noradrenergic (phenylephrine, salbutamol, clonidine) dopaminergic (L-dopa(Sinemet) transdihydrolisuride, apomorphine) and serotonergic (fluoxetine, 5-methoxy DMT) neurotransmitter systems. Results showed that all agents alleviated forgetting in a dose dependent fashion. Untrained mice treated with the most effective dose of representative drugs from each class did not exhibit avoidance behavior at testing indicating that the improved performance of trained animals was probably not the result of increased activity or other non-memorial effects of the drugs. It was concluded that pharmacological agents which stimulate monoamine systems may improve memory retrieval by activating a non-specific neural system which controls arousal, attention and motor readiness.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(88)90427-3</identifier><identifier>PMID: 2902645</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Active avoidance ; Animals ; Avoidance Learning - drug effects ; Biogenic amines ; Biogenic Amines - physiology ; Biological and medical sciences ; Dopamine - physiology ; Forgetting ; Male ; Medical sciences ; Memory - drug effects ; Memory facilitation ; Memory processing ; Memory retrieval ; Mice ; Miscellaneous ; Neuropharmacology ; Neurotransmitter Agents - physiology ; Neurotransmitters. Neurotransmission. Receptors ; Norepinephrine - physiology ; Pharmacology. Drug treatments ; Serotonin - physiology</subject><ispartof>Pharmacology, biochemistry and behavior, 1988-05, Vol.30 (1), p.77-81</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-7b83dc28c4c38f320419720ca1d002417406a5d671f93fafaa6cb4172d8e45ef3</citedby><cites>FETCH-LOGICAL-c448t-7b83dc28c4c38f320419720ca1d002417406a5d671f93fafaa6cb4172d8e45ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(88)90427-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7214372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2902645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quartermain, David</creatorcontrib><creatorcontrib>Judge, Martin E.</creatorcontrib><creatorcontrib>Leo, Paul</creatorcontrib><title>Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Mice were trained in one-way active avoidance to a criterion of
3
4
avoidances and tested under extinction conditions one week later when substantial forgetting had occurred. Thirty min prior to testing animals were injected with either saline or different doses of drugs which activate the noradrenergic (phenylephrine, salbutamol, clonidine) dopaminergic (L-dopa(Sinemet) transdihydrolisuride, apomorphine) and serotonergic (fluoxetine, 5-methoxy DMT) neurotransmitter systems. Results showed that all agents alleviated forgetting in a dose dependent fashion. Untrained mice treated with the most effective dose of representative drugs from each class did not exhibit avoidance behavior at testing indicating that the improved performance of trained animals was probably not the result of increased activity or other non-memorial effects of the drugs. It was concluded that pharmacological agents which stimulate monoamine systems may improve memory retrieval by activating a non-specific neural system which controls arousal, attention and motor readiness.</description><subject>Active avoidance</subject><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Biogenic amines</subject><subject>Biogenic Amines - physiology</subject><subject>Biological and medical sciences</subject><subject>Dopamine - physiology</subject><subject>Forgetting</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Memory facilitation</subject><subject>Memory processing</subject><subject>Memory retrieval</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Norepinephrine - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Serotonin - physiology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9vEzEQxS0EStPAN6DSHhAqh4Xxn117L5WiqgWkSlzgiuV4x8HV7jrY3kr59jgkyrFwGmneb55G7xHylsJHCrT9BNDRmkMjr5X60IFgsuYvyJIqyeuGSvmSLM_IBblM6RGgUK1ckAXrgLWiWZKf65xxmk32YaqCq1yIW8zZT9tqs692v0wcjQ1D2HprhiplP87DGTajnzAWqZpwjiFHM6XRF8NYpX3KOKbX5JUzQ8I3p7kiP-7vvt9-qR--ff56u36orRAq13KjeG-ZssJy5TgDQTvJwBraAzBBpYDWNH0rqeu4M86Y1m7KmvUKRYOOr8j7o-8uht8zpqxHnywOg5kwzElLJSRl0P4TpA3lreDiP0AABR0voDiCNoaUIjq9i340ca8p6ENR-tCCPrSgldJ_i9KHs6uT_7wZsT8fnZop-ruTblKJ3pVsrU9nTDIquGQFuzliWNJ98hh1sh4ni72PaLPug3_-jz9UNq_x</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Quartermain, David</creator><creator>Judge, Martin E.</creator><creator>Leo, Paul</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems</title><author>Quartermain, David ; Judge, Martin E. ; Leo, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-7b83dc28c4c38f320419720ca1d002417406a5d671f93fafaa6cb4172d8e45ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Active avoidance</topic><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Biogenic amines</topic><topic>Biogenic Amines - physiology</topic><topic>Biological and medical sciences</topic><topic>Dopamine - physiology</topic><topic>Forgetting</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Memory facilitation</topic><topic>Memory processing</topic><topic>Memory retrieval</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Norepinephrine - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Serotonin - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quartermain, David</creatorcontrib><creatorcontrib>Judge, Martin E.</creatorcontrib><creatorcontrib>Leo, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quartermain, David</au><au>Judge, Martin E.</au><au>Leo, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>30</volume><issue>1</issue><spage>77</spage><epage>81</epage><pages>77-81</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Mice were trained in one-way active avoidance to a criterion of
3
4
avoidances and tested under extinction conditions one week later when substantial forgetting had occurred. Thirty min prior to testing animals were injected with either saline or different doses of drugs which activate the noradrenergic (phenylephrine, salbutamol, clonidine) dopaminergic (L-dopa(Sinemet) transdihydrolisuride, apomorphine) and serotonergic (fluoxetine, 5-methoxy DMT) neurotransmitter systems. Results showed that all agents alleviated forgetting in a dose dependent fashion. Untrained mice treated with the most effective dose of representative drugs from each class did not exhibit avoidance behavior at testing indicating that the improved performance of trained animals was probably not the result of increased activity or other non-memorial effects of the drugs. It was concluded that pharmacological agents which stimulate monoamine systems may improve memory retrieval by activating a non-specific neural system which controls arousal, attention and motor readiness.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2902645</pmid><doi>10.1016/0091-3057(88)90427-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1988-05, Vol.30 (1), p.77-81 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Active avoidance Animals Avoidance Learning - drug effects Biogenic amines Biogenic Amines - physiology Biological and medical sciences Dopamine - physiology Forgetting Male Medical sciences Memory - drug effects Memory facilitation Memory processing Memory retrieval Mice Miscellaneous Neuropharmacology Neurotransmitter Agents - physiology Neurotransmitters. Neurotransmission. Receptors Norepinephrine - physiology Pharmacology. Drug treatments Serotonin - physiology |
| title | Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems |
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