Cylindrical fiberoptic light diffuser for medical applications
Background and Objective A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT. Study Design/Materials and Methods The diffuser is based on a polymer optical fibe...
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| Veröffentlicht in: | Lasers in surgery and medicine 1996, Vol.19 (2), p.159-167 |
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| container_title | Lasers in surgery and medicine |
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| creator | Mizeret, Jérôme C. van den Bergh, Hubert E. |
| description | Background and Objective
A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT.
Study Design/Materials and Methods
The diffuser is based on a polymer optical fiber. The coupling of the light out of the core is controlled by the roughness mechanically induced on the surface of the core. The light is then isotropically diffused by a thin layer of a scattering medium. The active length can be 100 mm or more, whereas the outer diameter is 1 mm or less. The diffuser is flexible and can be introduced in tissue though a hypodermic needle.
Results
The main property of this light diffuser is the homogeneity of the light intensity emitted along its whole active length and around its circumference (360°). Various intensity profiles can be made, including M‐shape profiles for a homogeneous irradiance (±10%) at a certain depth in the tissue. Furthermore, the diffuser is essentially isotropic and its optical properties are hardly dependent on wavelength.
Conclusions
A diffuser for interstitial and intraluminal PDT has been developed. It is flexible, homogeneous, independent on wavelength, and can be made with a very high length‐to‐diameter ratio. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-9101(1996)19:2<159::AID-LSM6>3.0.CO;2-R |
| format | Article |
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A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT.
Study Design/Materials and Methods
The diffuser is based on a polymer optical fiber. The coupling of the light out of the core is controlled by the roughness mechanically induced on the surface of the core. The light is then isotropically diffused by a thin layer of a scattering medium. The active length can be 100 mm or more, whereas the outer diameter is 1 mm or less. The diffuser is flexible and can be introduced in tissue though a hypodermic needle.
Results
The main property of this light diffuser is the homogeneity of the light intensity emitted along its whole active length and around its circumference (360°). Various intensity profiles can be made, including M‐shape profiles for a homogeneous irradiance (±10%) at a certain depth in the tissue. Furthermore, the diffuser is essentially isotropic and its optical properties are hardly dependent on wavelength.
Conclusions
A diffuser for interstitial and intraluminal PDT has been developed. It is flexible, homogeneous, independent on wavelength, and can be made with a very high length‐to‐diameter ratio. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/(SICI)1096-9101(1996)19:2<159::AID-LSM6>3.0.CO;2-R</identifier><identifier>PMID: 8887918</identifier><identifier>CODEN: LSMEDI</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; Fiber Optic Technology - instrumentation ; interstitial phototherapy ; intravascular phototherapy ; light diffuser ; Medical sciences ; Optical Fibers ; Photochemotherapy - instrumentation ; photodynamic therapy ; Photoradiation therapy and photosensitizing agent ; Phototherapy - instrumentation ; Physical Phenomena ; Physics ; Treatment with physical agents ; Treatment. General aspects ; Tumors</subject><ispartof>Lasers in surgery and medicine, 1996, Vol.19 (2), p.159-167</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4896-6a8ed678de4687f10fa3cdc24da83e6d3182fe39416d8134a1c809f04cca0ec13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9101%281996%2919%3A2%3C159%3A%3AAID-LSM6%3E3.0.CO%3B2-R$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9101%281996%2919%3A2%3C159%3A%3AAID-LSM6%3E3.0.CO%3B2-R$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3230318$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8887918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizeret, Jérôme C.</creatorcontrib><creatorcontrib>van den Bergh, Hubert E.</creatorcontrib><title>Cylindrical fiberoptic light diffuser for medical applications</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objective
A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT.
Study Design/Materials and Methods
The diffuser is based on a polymer optical fiber. The coupling of the light out of the core is controlled by the roughness mechanically induced on the surface of the core. The light is then isotropically diffused by a thin layer of a scattering medium. The active length can be 100 mm or more, whereas the outer diameter is 1 mm or less. The diffuser is flexible and can be introduced in tissue though a hypodermic needle.
Results
The main property of this light diffuser is the homogeneity of the light intensity emitted along its whole active length and around its circumference (360°). Various intensity profiles can be made, including M‐shape profiles for a homogeneous irradiance (±10%) at a certain depth in the tissue. Furthermore, the diffuser is essentially isotropic and its optical properties are hardly dependent on wavelength.
Conclusions
A diffuser for interstitial and intraluminal PDT has been developed. It is flexible, homogeneous, independent on wavelength, and can be made with a very high length‐to‐diameter ratio. © 1996 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>Fiber Optic Technology - instrumentation</subject><subject>interstitial phototherapy</subject><subject>intravascular phototherapy</subject><subject>light diffuser</subject><subject>Medical sciences</subject><subject>Optical Fibers</subject><subject>Photochemotherapy - instrumentation</subject><subject>photodynamic therapy</subject><subject>Photoradiation therapy and photosensitizing agent</subject><subject>Phototherapy - instrumentation</subject><subject>Physical Phenomena</subject><subject>Physics</subject><subject>Treatment with physical agents</subject><subject>Treatment. General aspects</subject><subject>Tumors</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1r2zAUhsXY6LJuP2HgizHaC2dHlmpL2SgU92OBdIF0H9CbgypLmzon9iSHNf--cmJys9EbfZ2XRy8PIRMKYwqQfTi6mZbTYwoyTyUFekSlzI-pnGSf6ImcTM6m5-ns5jo_ZWMYl_OPWbp4Rkb7-HMyAhrPAmT2krwK4R4AWAbFATkQQhSSihE5LTe1W1XeaVUn1t0Z37Sd00ntfv7qkspZuw7GJ7bxydJU25Rq2zoeOteswmvywqo6mDfDfki-XV58LT-ns_nVtDybpZqLWCFXwlR5ISrDc1FYClYxXemMV0owk1eMiswaJjnNK0EZV1TH1ha41gqMpuyQvN9xW9_8WZvQ4dIFbeparUyzDlgIXgBIiMHFLqh9E4I3FlvvlspvkAL2UhF7qdhbwt4S9lLjghlGqYhRKvZSkSFgOY_Piwh9O_y-vosW9sjBYpy_G-YqREPWq5V2YR9jGQO2jQ3d_rrabP4p9mSv_9Ta3iM03UFd6MzDHqr8b8wLVpzgjy9XeMv4jH8_v8WCPQLdv6z8</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Mizeret, Jérôme C.</creator><creator>van den Bergh, Hubert E.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Cylindrical fiberoptic light diffuser for medical applications</title><author>Mizeret, Jérôme C. ; van den Bergh, Hubert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4896-6a8ed678de4687f10fa3cdc24da83e6d3182fe39416d8134a1c809f04cca0ec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Fiber Optic Technology - instrumentation</topic><topic>interstitial phototherapy</topic><topic>intravascular phototherapy</topic><topic>light diffuser</topic><topic>Medical sciences</topic><topic>Optical Fibers</topic><topic>Photochemotherapy - instrumentation</topic><topic>photodynamic therapy</topic><topic>Photoradiation therapy and photosensitizing agent</topic><topic>Phototherapy - instrumentation</topic><topic>Physical Phenomena</topic><topic>Physics</topic><topic>Treatment with physical agents</topic><topic>Treatment. General aspects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizeret, Jérôme C.</creatorcontrib><creatorcontrib>van den Bergh, Hubert E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizeret, Jérôme C.</au><au>van den Bergh, Hubert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cylindrical fiberoptic light diffuser for medical applications</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>1996</date><risdate>1996</risdate><volume>19</volume><issue>2</issue><spage>159</spage><epage>167</epage><pages>159-167</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><coden>LSMEDI</coden><abstract>Background and Objective
A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT.
Study Design/Materials and Methods
The diffuser is based on a polymer optical fiber. The coupling of the light out of the core is controlled by the roughness mechanically induced on the surface of the core. The light is then isotropically diffused by a thin layer of a scattering medium. The active length can be 100 mm or more, whereas the outer diameter is 1 mm or less. The diffuser is flexible and can be introduced in tissue though a hypodermic needle.
Results
The main property of this light diffuser is the homogeneity of the light intensity emitted along its whole active length and around its circumference (360°). Various intensity profiles can be made, including M‐shape profiles for a homogeneous irradiance (±10%) at a certain depth in the tissue. Furthermore, the diffuser is essentially isotropic and its optical properties are hardly dependent on wavelength.
Conclusions
A diffuser for interstitial and intraluminal PDT has been developed. It is flexible, homogeneous, independent on wavelength, and can be made with a very high length‐to‐diameter ratio. © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>8887918</pmid><doi>10.1002/(SICI)1096-9101(1996)19:2<159::AID-LSM6>3.0.CO;2-R</doi><tpages>9</tpages></addata></record> |
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| ispartof | Lasers in surgery and medicine, 1996, Vol.19 (2), p.159-167 |
| issn | 0196-8092 1096-9101 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Fiber Optic Technology - instrumentation interstitial phototherapy intravascular phototherapy light diffuser Medical sciences Optical Fibers Photochemotherapy - instrumentation photodynamic therapy Photoradiation therapy and photosensitizing agent Phototherapy - instrumentation Physical Phenomena Physics Treatment with physical agents Treatment. General aspects Tumors |
| title | Cylindrical fiberoptic light diffuser for medical applications |
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