Simultaneous aortic reconstruction and bilateral renal revascularization: Is this a safe and effective procedure?

Between 1982 and 1987, 32 patients with severe aortorenal atherosclerosis had simultaneous aortic and bilateral renal revascularization. All patients were hypertensive. Eighteen patients (56%) had renal insufficiency with a mean serum creatinine (SC) of 2.8 mg/dl. Nine patients had an aortic aneurys...

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Veröffentlicht in:Journal of vascular surgery 1988-10, Vol.8 (4), p.357-366
Hauptverfasser: O'Mara, Charles S., Maples, Michael D., Kilgore, Thomas L., McMullan, Martin H., Tyler, Henry B., Mundinger, Gerhard H., Kennedy, Ronald E.
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container_end_page 366
container_issue 4
container_start_page 357
container_title Journal of vascular surgery
container_volume 8
creator O'Mara, Charles S.
Maples, Michael D.
Kilgore, Thomas L.
McMullan, Martin H.
Tyler, Henry B.
Mundinger, Gerhard H.
Kennedy, Ronald E.
description Between 1982 and 1987, 32 patients with severe aortorenal atherosclerosis had simultaneous aortic and bilateral renal revascularization. All patients were hypertensive. Eighteen patients (56%) had renal insufficiency with a mean serum creatinine (SC) of 2.8 mg/dl. Nine patients had an aortic aneurysm; the remaining 23 patients had aortoiliac occlusive disease of varying severity. Aortic reconstruction was done with either a straight (six patients) or bifurcated (26 patients) Dacron graft. Renal revascularization was accomplished with either bypass (60 arteries) or transaortic endarterectomy (four arteries). One patient died of pulmonary embolism (operative mortality rate 3%). Beneficial blood pressure response was achieved in 28 of 31 survivors, (90%). Among the 18 patients with renal insufficiency, mean SC was 2.80 ± 1.18 mg/dl preoperatively and 1.65 ± 0.48 mg/dl postoperatively (p < 0.001). Among eight patients with severe renal dysfunction before surgery (SC greater than 3 mg/dl), mean SC was 3.90 ± 0.85 mg/dl before and 1.79 ± 0.69 mg/dl after operation (p < 0.001). In follow-up extending to 58 months (mean 27.6 months), five late deaths occurred; cumulative survival was 94% at 2 years and 60% at 4 years. There were no instances of worsening hypertension; one patient had deteriorating renal function. These results indicate that severe aortorenal atherosclerosis can be managed with simultaneous aortic reconstruction and bilateral renal revascularization at low operative risk. In addition, there can be high expectation of significant and persisting benefit in both hypertension and renal dysfunction after operation.
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All patients were hypertensive. Eighteen patients (56%) had renal insufficiency with a mean serum creatinine (SC) of 2.8 mg/dl. Nine patients had an aortic aneurysm; the remaining 23 patients had aortoiliac occlusive disease of varying severity. Aortic reconstruction was done with either a straight (six patients) or bifurcated (26 patients) Dacron graft. Renal revascularization was accomplished with either bypass (60 arteries) or transaortic endarterectomy (four arteries). One patient died of pulmonary embolism (operative mortality rate 3%). Beneficial blood pressure response was achieved in 28 of 31 survivors, (90%). Among the 18 patients with renal insufficiency, mean SC was 2.80 ± 1.18 mg/dl preoperatively and 1.65 ± 0.48 mg/dl postoperatively (p &lt; 0.001). Among eight patients with severe renal dysfunction before surgery (SC greater than 3 mg/dl), mean SC was 3.90 ± 0.85 mg/dl before and 1.79 ± 0.69 mg/dl after operation (p &lt; 0.001). In follow-up extending to 58 months (mean 27.6 months), five late deaths occurred; cumulative survival was 94% at 2 years and 60% at 4 years. There were no instances of worsening hypertension; one patient had deteriorating renal function. These results indicate that severe aortorenal atherosclerosis can be managed with simultaneous aortic reconstruction and bilateral renal revascularization at low operative risk. 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All patients were hypertensive. Eighteen patients (56%) had renal insufficiency with a mean serum creatinine (SC) of 2.8 mg/dl. Nine patients had an aortic aneurysm; the remaining 23 patients had aortoiliac occlusive disease of varying severity. Aortic reconstruction was done with either a straight (six patients) or bifurcated (26 patients) Dacron graft. Renal revascularization was accomplished with either bypass (60 arteries) or transaortic endarterectomy (four arteries). One patient died of pulmonary embolism (operative mortality rate 3%). Beneficial blood pressure response was achieved in 28 of 31 survivors, (90%). Among the 18 patients with renal insufficiency, mean SC was 2.80 ± 1.18 mg/dl preoperatively and 1.65 ± 0.48 mg/dl postoperatively (p &lt; 0.001). Among eight patients with severe renal dysfunction before surgery (SC greater than 3 mg/dl), mean SC was 3.90 ± 0.85 mg/dl before and 1.79 ± 0.69 mg/dl after operation (p &lt; 0.001). In follow-up extending to 58 months (mean 27.6 months), five late deaths occurred; cumulative survival was 94% at 2 years and 60% at 4 years. There were no instances of worsening hypertension; one patient had deteriorating renal function. These results indicate that severe aortorenal atherosclerosis can be managed with simultaneous aortic reconstruction and bilateral renal revascularization at low operative risk. In addition, there can be high expectation of significant and persisting benefit in both hypertension and renal dysfunction after operation.</description><subject>Aged</subject><subject>Aorta, Abdominal - surgery</subject><subject>Aortic Diseases - mortality</subject><subject>Aortic Diseases - surgery</subject><subject>Arteriosclerosis - mortality</subject><subject>Arteriosclerosis - surgery</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis</subject><subject>Endarterectomy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polyethylene Terephthalates</subject><subject>Renal Artery - surgery</subject><subject>Renal Artery Obstruction - mortality</subject><subject>Renal Artery Obstruction - surgery</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Vascular surgery: aorta, extremities, vena cava. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Mara, Charles S.</creatorcontrib><creatorcontrib>Maples, Michael D.</creatorcontrib><creatorcontrib>Kilgore, Thomas L.</creatorcontrib><creatorcontrib>McMullan, Martin H.</creatorcontrib><creatorcontrib>Tyler, Henry B.</creatorcontrib><creatorcontrib>Mundinger, Gerhard H.</creatorcontrib><creatorcontrib>Kennedy, Ronald E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Mara, Charles S.</au><au>Maples, Michael D.</au><au>Kilgore, Thomas L.</au><au>McMullan, Martin H.</au><au>Tyler, Henry B.</au><au>Mundinger, Gerhard H.</au><au>Kennedy, Ronald E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous aortic reconstruction and bilateral renal revascularization: Is this a safe and effective procedure?</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>1988-10</date><risdate>1988</risdate><volume>8</volume><issue>4</issue><spage>357</spage><epage>366</epage><pages>357-366</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><coden>JVSUES</coden><abstract>Between 1982 and 1987, 32 patients with severe aortorenal atherosclerosis had simultaneous aortic and bilateral renal revascularization. All patients were hypertensive. Eighteen patients (56%) had renal insufficiency with a mean serum creatinine (SC) of 2.8 mg/dl. Nine patients had an aortic aneurysm; the remaining 23 patients had aortoiliac occlusive disease of varying severity. Aortic reconstruction was done with either a straight (six patients) or bifurcated (26 patients) Dacron graft. Renal revascularization was accomplished with either bypass (60 arteries) or transaortic endarterectomy (four arteries). One patient died of pulmonary embolism (operative mortality rate 3%). Beneficial blood pressure response was achieved in 28 of 31 survivors, (90%). Among the 18 patients with renal insufficiency, mean SC was 2.80 ± 1.18 mg/dl preoperatively and 1.65 ± 0.48 mg/dl postoperatively (p &lt; 0.001). Among eight patients with severe renal dysfunction before surgery (SC greater than 3 mg/dl), mean SC was 3.90 ± 0.85 mg/dl before and 1.79 ± 0.69 mg/dl after operation (p &lt; 0.001). In follow-up extending to 58 months (mean 27.6 months), five late deaths occurred; cumulative survival was 94% at 2 years and 60% at 4 years. There were no instances of worsening hypertension; one patient had deteriorating renal function. These results indicate that severe aortorenal atherosclerosis can be managed with simultaneous aortic reconstruction and bilateral renal revascularization at low operative risk. In addition, there can be high expectation of significant and persisting benefit in both hypertension and renal dysfunction after operation.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2971824</pmid><doi>10.1016/0741-5214(88)90096-1</doi><tpages>10</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Aged
Aorta, Abdominal - surgery
Aortic Diseases - mortality
Aortic Diseases - surgery
Arteriosclerosis - mortality
Arteriosclerosis - surgery
Biological and medical sciences
Blood Vessel Prosthesis
Endarterectomy
Female
Follow-Up Studies
Humans
Male
Medical sciences
Middle Aged
Polyethylene Terephthalates
Renal Artery - surgery
Renal Artery Obstruction - mortality
Renal Artery Obstruction - surgery
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
title Simultaneous aortic reconstruction and bilateral renal revascularization: Is this a safe and effective procedure?
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