Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization

We have previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous system. Neuronal pentraxin 1 (NP1) was identified as a rat protein that may mediate the uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. NP2...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genomics (San Diego, Calif.) Calif.), 1996-09, Vol.36 (3), p.543-545
Hauptverfasser: Omeis, Ibrahim A., Hsu, Yung-Chih, Perin, Mark S.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 545
container_issue 3
container_start_page 543
container_title Genomics (San Diego, Calif.)
container_volume 36
creator Omeis, Ibrahim A.
Hsu, Yung-Chih
Perin, Mark S.
description We have previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous system. Neuronal pentraxin 1 (NP1) was identified as a rat protein that may mediate the uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. NP2 was identified as a separate gene discovered by screening for a human homolog for NP1. Here, we report human cDNA and mouse genomic DNA sequences for NP1 (gene symbol NPTX1). Human NP1 and mouse NP1 show 95 and 99% amino acid identity, respectively, with rat NP1 and conserve all potential glycosylation sites. Like rat NP1, human NP1 message is large (6.5 kb) and is exclusively localized to the nervous system. The mouse NP1 gene is 13 kb in length and contains four introns that break the coding sequence of NP1 in the same positions as the introns of the human NP2 gene. The human and mouse NP1 genes are localized to chromosome 17q25.1–q25.2 and chromosome 11e2–e1.3, respectively. These data demonstrate the existence of a separate family of pentraxin proteins that are expressed in the human brain and other tissues and that may play important roles in the uptake of extracellular material.
doi_str_mv 10.1006/geno.1996.0503
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78469441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0888754396905030</els_id><sourcerecordid>78469441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-ec8a5948920f0c761b993be0e26a05a5212d8012043205d546927a845e7bad973</originalsourceid><addsrcrecordid>eNp1kM9rFDEYhkNR6rZ69SbkINJCZ_2SSWYSb7L0h7CtBVvwFrKZbzU6k9Rkplj_-ma7S2-eAvme902-h5C3DOYMoPn4A0OcM62bOUio98iMgdKVakTzgsxAKVW1UtSvyEHOvwBA14rvk_1yL7hiM_L7Mk4ZqQ0dvZgGG-gVTikG29NrDGOyf32gjB5dXd98Z8ef6CKGjOnejj6GE3pe3h68o9_GNLlxSnjyVLT4meIQcxxKyzI62_t_T4HX5OXa9hnf7M5Dcnt2erO4qJZfz78sPi8rJ2oxVuiUlVoozWENrm3YSut6hYC8sSCt5Ix3ChgHUXOQnRSN5q1VQmK7sp1u60PyYdt7l-KfCfNoBp8d9r0NWLY1rSoRIVgB51vQpZhzwrW5S36w6cEwMBu7ZmPXbOyajd0SeLdrnlYDds_4TmeZv9_NbS57r5MNzudnrOZcKdkUTG0xLBbuPSaTncfgsPMJ3Wi66P_3g0crXZRv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78469441</pqid></control><display><type>article</type><title>Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Omeis, Ibrahim A. ; Hsu, Yung-Chih ; Perin, Mark S.</creator><creatorcontrib>Omeis, Ibrahim A. ; Hsu, Yung-Chih ; Perin, Mark S.</creatorcontrib><description>We have previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous system. Neuronal pentraxin 1 (NP1) was identified as a rat protein that may mediate the uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. NP2 was identified as a separate gene discovered by screening for a human homolog for NP1. Here, we report human cDNA and mouse genomic DNA sequences for NP1 (gene symbol NPTX1). Human NP1 and mouse NP1 show 95 and 99% amino acid identity, respectively, with rat NP1 and conserve all potential glycosylation sites. Like rat NP1, human NP1 message is large (6.5 kb) and is exclusively localized to the nervous system. The mouse NP1 gene is 13 kb in length and contains four introns that break the coding sequence of NP1 in the same positions as the introns of the human NP2 gene. The human and mouse NP1 genes are localized to chromosome 17q25.1–q25.2 and chromosome 11e2–e1.3, respectively. These data demonstrate the existence of a separate family of pentraxin proteins that are expressed in the human brain and other tissues and that may play important roles in the uptake of extracellular material.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1996.0503</identifier><identifier>PMID: 8884281</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; C-Reactive Protein - genetics ; Carrier Proteins - genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 17 ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Humans ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nerve Tissue Proteins - genetics ; Sequence Homology, Amino Acid</subject><ispartof>Genomics (San Diego, Calif.), 1996-09, Vol.36 (3), p.543-545</ispartof><rights>1996 Academic Press</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-ec8a5948920f0c761b993be0e26a05a5212d8012043205d546927a845e7bad973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1996.0503$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3228856$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8884281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Omeis, Ibrahim A.</creatorcontrib><creatorcontrib>Hsu, Yung-Chih</creatorcontrib><creatorcontrib>Perin, Mark S.</creatorcontrib><title>Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>We have previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous system. Neuronal pentraxin 1 (NP1) was identified as a rat protein that may mediate the uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. NP2 was identified as a separate gene discovered by screening for a human homolog for NP1. Here, we report human cDNA and mouse genomic DNA sequences for NP1 (gene symbol NPTX1). Human NP1 and mouse NP1 show 95 and 99% amino acid identity, respectively, with rat NP1 and conserve all potential glycosylation sites. Like rat NP1, human NP1 message is large (6.5 kb) and is exclusively localized to the nervous system. The mouse NP1 gene is 13 kb in length and contains four introns that break the coding sequence of NP1 in the same positions as the introns of the human NP2 gene. The human and mouse NP1 genes are localized to chromosome 17q25.1–q25.2 and chromosome 11e2–e1.3, respectively. These data demonstrate the existence of a separate family of pentraxin proteins that are expressed in the human brain and other tissues and that may play important roles in the uptake of extracellular material.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - genetics</subject><subject>Carrier Proteins - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Sequence Homology, Amino Acid</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9rFDEYhkNR6rZ69SbkINJCZ_2SSWYSb7L0h7CtBVvwFrKZbzU6k9Rkplj_-ma7S2-eAvme902-h5C3DOYMoPn4A0OcM62bOUio98iMgdKVakTzgsxAKVW1UtSvyEHOvwBA14rvk_1yL7hiM_L7Mk4ZqQ0dvZgGG-gVTikG29NrDGOyf32gjB5dXd98Z8ef6CKGjOnejj6GE3pe3h68o9_GNLlxSnjyVLT4meIQcxxKyzI62_t_T4HX5OXa9hnf7M5Dcnt2erO4qJZfz78sPi8rJ2oxVuiUlVoozWENrm3YSut6hYC8sSCt5Ix3ChgHUXOQnRSN5q1VQmK7sp1u60PyYdt7l-KfCfNoBp8d9r0NWLY1rSoRIVgB51vQpZhzwrW5S36w6cEwMBu7ZmPXbOyajd0SeLdrnlYDds_4TmeZv9_NbS57r5MNzudnrOZcKdkUTG0xLBbuPSaTncfgsPMJ3Wi66P_3g0crXZRv</recordid><startdate>19960915</startdate><enddate>19960915</enddate><creator>Omeis, Ibrahim A.</creator><creator>Hsu, Yung-Chih</creator><creator>Perin, Mark S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960915</creationdate><title>Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization</title><author>Omeis, Ibrahim A. ; Hsu, Yung-Chih ; Perin, Mark S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-ec8a5948920f0c761b993be0e26a05a5212d8012043205d546927a845e7bad973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - genetics</topic><topic>Carrier Proteins - genetics</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omeis, Ibrahim A.</creatorcontrib><creatorcontrib>Hsu, Yung-Chih</creatorcontrib><creatorcontrib>Perin, Mark S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omeis, Ibrahim A.</au><au>Hsu, Yung-Chih</au><au>Perin, Mark S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1996-09-15</date><risdate>1996</risdate><volume>36</volume><issue>3</issue><spage>543</spage><epage>545</epage><pages>543-545</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous system. Neuronal pentraxin 1 (NP1) was identified as a rat protein that may mediate the uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. NP2 was identified as a separate gene discovered by screening for a human homolog for NP1. Here, we report human cDNA and mouse genomic DNA sequences for NP1 (gene symbol NPTX1). Human NP1 and mouse NP1 show 95 and 99% amino acid identity, respectively, with rat NP1 and conserve all potential glycosylation sites. Like rat NP1, human NP1 message is large (6.5 kb) and is exclusively localized to the nervous system. The mouse NP1 gene is 13 kb in length and contains four introns that break the coding sequence of NP1 in the same positions as the introns of the human NP2 gene. The human and mouse NP1 genes are localized to chromosome 17q25.1–q25.2 and chromosome 11e2–e1.3, respectively. These data demonstrate the existence of a separate family of pentraxin proteins that are expressed in the human brain and other tissues and that may play important roles in the uptake of extracellular material.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8884281</pmid><doi>10.1006/geno.1996.0503</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0888-7543
ispartof Genomics (San Diego, Calif.), 1996-09, Vol.36 (3), p.543-545
issn 0888-7543
1089-8646
language eng
recordid cdi_proquest_miscellaneous_78469441
source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Amino Acid Sequence
Animals
Biological and medical sciences
C-Reactive Protein - genetics
Carrier Proteins - genetics
Chromosome Mapping
Chromosomes, Human, Pair 17
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nerve Tissue Proteins - genetics
Sequence Homology, Amino Acid
title Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T14%3A52%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mouse%20and%20Human%20Neuronal%20Pentraxin%201%20(NPTX1):%20Conservation,%20Genomic%20Structure,%20and%20Chromosomal%20Localization&rft.jtitle=Genomics%20(San%20Diego,%20Calif.)&rft.au=Omeis,%20Ibrahim%20A.&rft.date=1996-09-15&rft.volume=36&rft.issue=3&rft.spage=543&rft.epage=545&rft.pages=543-545&rft.issn=0888-7543&rft.eissn=1089-8646&rft_id=info:doi/10.1006/geno.1996.0503&rft_dat=%3Cproquest_cross%3E78469441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78469441&rft_id=info:pmid/8884281&rft_els_id=S0888754396905030&rfr_iscdi=true