Breakdown of Bruch's membrane after subretinal injection of vitreous: role of cellular processes
It was recently shown that the injection of autologous vitreous beneath the retina of rabbits leads to retinal degeneration, subretinal cellular proliferation and neovascularization. The current study, using electron microscopy, was designed to determine the cellular processes involved in the breakd...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 1988-07, Vol.95 (7), p.925-929 |
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| container_title | Ophthalmology (Rochester, Minn.) |
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| creator | ZHI-REN ZHU GOODNIGHT, R ISHIBASHI, T SORGENTE, N OGDEN, T. E RYAN, S. J |
| description | It was recently shown that the injection of autologous vitreous beneath the retina of rabbits leads to retinal degeneration, subretinal cellular proliferation and neovascularization. The current study, using electron microscopy, was designed to determine the cellular processes involved in the breakdown of Bruch's membrane in this model. Bruch's membrane was not mechanically damaged by the injection and appeared intact for the first 1 to 2 days after injection. Subsequently, numerous breaks in Bruch's membrane were found associated with invasion of macrophages and fibroblasts; in addition, budding and penetration of retinal pigment epithelial (RPE) and choroidal endothelial cells into Bruch's membrane were noted. Although it was not proven that these cells, per se, were responsible for the breaks, that these cells actively penetrate Bruch's membrane is a reasonable hypothesis. |
| doi_str_mv | 10.1016/S0161-6420(88)33074-5 |
| format | Article |
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E ; RYAN, S. J</creator><creatorcontrib>ZHI-REN ZHU ; GOODNIGHT, R ; ISHIBASHI, T ; SORGENTE, N ; OGDEN, T. E ; RYAN, S. J</creatorcontrib><description>It was recently shown that the injection of autologous vitreous beneath the retina of rabbits leads to retinal degeneration, subretinal cellular proliferation and neovascularization. The current study, using electron microscopy, was designed to determine the cellular processes involved in the breakdown of Bruch's membrane in this model. Bruch's membrane was not mechanically damaged by the injection and appeared intact for the first 1 to 2 days after injection. Subsequently, numerous breaks in Bruch's membrane were found associated with invasion of macrophages and fibroblasts; in addition, budding and penetration of retinal pigment epithelial (RPE) and choroidal endothelial cells into Bruch's membrane were noted. Although it was not proven that these cells, per se, were responsible for the breaks, that these cells actively penetrate Bruch's membrane is a reasonable hypothesis.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(88)33074-5</identifier><identifier>PMID: 3174042</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Cell Division ; Choroid - pathology ; Choroid - ultrastructure ; Extracellular Matrix - metabolism ; Fibroblasts - physiology ; Injections ; Macrophages - physiology ; Medical sciences ; Microscopy, Electron ; Ophthalmology ; Pigment Epithelium of Eye - cytology ; Rabbits ; Retina - cytology ; Retina - physiology ; Retinopathies ; Vitreous Body</subject><ispartof>Ophthalmology (Rochester, Minn.), 1988-07, Vol.95 (7), p.925-929</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7710585$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3174042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZHI-REN ZHU</creatorcontrib><creatorcontrib>GOODNIGHT, R</creatorcontrib><creatorcontrib>ISHIBASHI, T</creatorcontrib><creatorcontrib>SORGENTE, N</creatorcontrib><creatorcontrib>OGDEN, T. E</creatorcontrib><creatorcontrib>RYAN, S. J</creatorcontrib><title>Breakdown of Bruch's membrane after subretinal injection of vitreous: role of cellular processes</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>It was recently shown that the injection of autologous vitreous beneath the retina of rabbits leads to retinal degeneration, subretinal cellular proliferation and neovascularization. The current study, using electron microscopy, was designed to determine the cellular processes involved in the breakdown of Bruch's membrane in this model. Bruch's membrane was not mechanically damaged by the injection and appeared intact for the first 1 to 2 days after injection. Subsequently, numerous breaks in Bruch's membrane were found associated with invasion of macrophages and fibroblasts; in addition, budding and penetration of retinal pigment epithelial (RPE) and choroidal endothelial cells into Bruch's membrane were noted. Although it was not proven that these cells, per se, were responsible for the breaks, that these cells actively penetrate Bruch's membrane is a reasonable hypothesis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Choroid - pathology</subject><subject>Choroid - ultrastructure</subject><subject>Extracellular Matrix - metabolism</subject><subject>Fibroblasts - physiology</subject><subject>Injections</subject><subject>Macrophages - physiology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Ophthalmology</subject><subject>Pigment Epithelium of Eye - cytology</subject><subject>Rabbits</subject><subject>Retina - cytology</subject><subject>Retina - physiology</subject><subject>Retinopathies</subject><subject>Vitreous Body</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kElPwzAQhS0EKqXwEyr5gFgOATveEm60YpMqcaD3YDtjkZKl2AmIf48LEZcZad6nmXkPoTklV5RQef0SC00kT8lFll0yRhRPxB6aUsHzhCvK9tH0HzlERyFsCCFSMj5BE0YVJzydoteFB_1edl8t7hxe-MG-nQfcQGO8bgFr14PHYTAe-qrVNa7aDdi-6n7xz6r30A3hBvuuht3EQl0PtfZ46zsLIUA4RgdO1wFOxj5D6_u79fIxWT0_PC1vV8k2ZaJPSiIkSJdp4NpYnUkHVLncEJZaVxoriMqjkVwZDtKAKlmZkpJLZbSENGczdPa3Nh7-GCD0RVOF3TfRRfywUBmXImMygvMRHEwDZbH1VaP9dzEmEvXTUdfB6trFGGwV_jGlKBGZYD9jjHIJ</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>ZHI-REN ZHU</creator><creator>GOODNIGHT, R</creator><creator>ISHIBASHI, T</creator><creator>SORGENTE, N</creator><creator>OGDEN, T. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breakdown of Bruch's membrane after subretinal injection of vitreous: role of cellular processes</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>95</volume><issue>7</issue><spage>925</spage><epage>929</epage><pages>925-929</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>It was recently shown that the injection of autologous vitreous beneath the retina of rabbits leads to retinal degeneration, subretinal cellular proliferation and neovascularization. The current study, using electron microscopy, was designed to determine the cellular processes involved in the breakdown of Bruch's membrane in this model. Bruch's membrane was not mechanically damaged by the injection and appeared intact for the first 1 to 2 days after injection. Subsequently, numerous breaks in Bruch's membrane were found associated with invasion of macrophages and fibroblasts; in addition, budding and penetration of retinal pigment epithelial (RPE) and choroidal endothelial cells into Bruch's membrane were noted. Although it was not proven that these cells, per se, were responsible for the breaks, that these cells actively penetrate Bruch's membrane is a reasonable hypothesis.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>3174042</pmid><doi>10.1016/S0161-6420(88)33074-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Ophthalmology (Rochester, Minn.), 1988-07, Vol.95 (7), p.925-929 |
| issn | 0161-6420 1549-4713 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell Division Choroid - pathology Choroid - ultrastructure Extracellular Matrix - metabolism Fibroblasts - physiology Injections Macrophages - physiology Medical sciences Microscopy, Electron Ophthalmology Pigment Epithelium of Eye - cytology Rabbits Retina - cytology Retina - physiology Retinopathies Vitreous Body |
| title | Breakdown of Bruch's membrane after subretinal injection of vitreous: role of cellular processes |
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