Comparison of the β-Adrenoceptor Affinity and Selectivity of Cetamolol, Atenolol, Betaxolol, and ICI-118,551

The objective of the present study was to compare the quantitative differences in the β1,- vs. β2-adrenoceptor affinity and selectivity of cetamolol and its enantiomers to the reference compounds atenolol, betaxolol, and ICI-118,551, using isolated tissues obtained from the dog, guinea pig, and rat....

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1988-08, Vol.12 (2), p.208-217
Hauptverfasser:	Rimele, Thomas J, Henry, Diane E, Giesa, Frank R, Buckley, Susan K, Geiger, Gabriella, Heaslip, Richard J, Lee, David K. H, Grimes, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Atenolol - pharmacology Betaxolol Biological and medical sciences Cardiovascular system Dogs Dose-Response Relationship, Drug Female Guinea Pigs In Vitro Techniques Male Medical sciences Miscellaneous Norepinephrine - metabolism Pharmacology. Drug treatments Propanolamines - pharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, beta - analysis Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism
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