Blood coagulation and platelet aggregation in major depression
Recently, it was found that the plasma of depressed patients significantly reduced the primary and secondary platelet aggregation to aggregating agents, such as ADP and collagen, in platelet rich plasma (PRP) of normal volunteers. Other authors found significantly decreased maximum amplitudes of adr...
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| Veröffentlicht in: | Journal of affective disorders 1996-09, Vol.40 (1), p.35-40 |
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| container_title | Journal of affective disorders |
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| creator | Maes, Michael Van der Planken, Marc Van Gastel, Ann Desnyder, Roger |
| description | Recently, it was found that the plasma of depressed patients significantly reduced the primary and secondary platelet aggregation to aggregating agents, such as ADP and collagen, in platelet rich plasma (PRP) of normal volunteers. Other authors found significantly decreased maximum amplitudes of adrenaline-induced platelet aggregation in major depressed patients versus normal controls. The aim of the present study was to examine platelet aggregation and blood coagulation in depression. Toward this end, the authors have measured secondary platelet aggregation to ADP and collagen, and the activated partial thromboplastin time (APTT) and prothrombin time (PT) in 16 normal volunteers, 16 minor, 40 simple major and 23 melancholic subjects. There were no significant differences in ADP- or collagen-induced platelet aggregability, APTT or PT between normal controls, minor, simple major or melancholic depressed patients. There were no significant relationships between severity of depression and APTT, PT or platelet aggregability to ADP or collagen. It is concluded that blood coagulation and platelet aggregability to ADP and collagen are probably not disordered in major depression. |
| doi_str_mv | 10.1016/0165-0327(96)00044-4 |
| format | Article |
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Other authors found significantly decreased maximum amplitudes of adrenaline-induced platelet aggregation in major depressed patients versus normal controls. The aim of the present study was to examine platelet aggregation and blood coagulation in depression. Toward this end, the authors have measured secondary platelet aggregation to ADP and collagen, and the activated partial thromboplastin time (APTT) and prothrombin time (PT) in 16 normal volunteers, 16 minor, 40 simple major and 23 melancholic subjects. There were no significant differences in ADP- or collagen-induced platelet aggregability, APTT or PT between normal controls, minor, simple major or melancholic depressed patients. There were no significant relationships between severity of depression and APTT, PT or platelet aggregability to ADP or collagen. It is concluded that blood coagulation and platelet aggregability to ADP and collagen are probably not disordered in major depression.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/0165-0327(96)00044-4</identifier><identifier>PMID: 8882912</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>ADP ; Adult ; Adult and adolescent clinical studies ; Aged ; Aggregation ; Biological and medical sciences ; Blood coagulation ; Collagen ; Depression ; Depressive Disorder - blood ; Depressive Disorder - diagnosis ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Partial Thromboplastin Time ; Platelet ; Platelet Aggregation - physiology ; Prothrombin Time ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reference Values ; Serotonin</subject><ispartof>Journal of affective disorders, 1996-09, Vol.40 (1), p.35-40</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-ef59bd3b8526466e2a0a8f30ad6a957fe3e920d336295d90473a6e8f345708153</citedby><cites>FETCH-LOGICAL-c386t-ef59bd3b8526466e2a0a8f30ad6a957fe3e920d336295d90473a6e8f345708153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-0327(96)00044-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3215686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8882912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Van der Planken, Marc</creatorcontrib><creatorcontrib>Van Gastel, Ann</creatorcontrib><creatorcontrib>Desnyder, Roger</creatorcontrib><title>Blood coagulation and platelet aggregation in major depression</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Recently, it was found that the plasma of depressed patients significantly reduced the primary and secondary platelet aggregation to aggregating agents, such as ADP and collagen, in platelet rich plasma (PRP) of normal volunteers. Other authors found significantly decreased maximum amplitudes of adrenaline-induced platelet aggregation in major depressed patients versus normal controls. The aim of the present study was to examine platelet aggregation and blood coagulation in depression. Toward this end, the authors have measured secondary platelet aggregation to ADP and collagen, and the activated partial thromboplastin time (APTT) and prothrombin time (PT) in 16 normal volunteers, 16 minor, 40 simple major and 23 melancholic subjects. There were no significant differences in ADP- or collagen-induced platelet aggregability, APTT or PT between normal controls, minor, simple major or melancholic depressed patients. There were no significant relationships between severity of depression and APTT, PT or platelet aggregability to ADP or collagen. It is concluded that blood coagulation and platelet aggregability to ADP and collagen are probably not disordered in major depression.</description><subject>ADP</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aggregation</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation</subject><subject>Collagen</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Partial Thromboplastin Time</subject><subject>Platelet</subject><subject>Platelet Aggregation - physiology</subject><subject>Prothrombin Time</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reference Values</subject><subject>Serotonin</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMoWi9voDALEV2M5n7ZCCreQHCj65AmZ0pkOqnJVPDtTWnp0kVITv7vHA4fQqcEXxNM5E09osWMqksjrzDGnLd8B02IUKylgqhdNNkiB-iwlK8KSaPwPtrXWlND6ATd3vcphcYnN1v2boxpaNwQmkV9Qw9j42azDLN1EIdm7r5SbgIsMpRS_47RXuf6Aieb-wh9Pj1-PLy0b-_Prw93b61nWo4tdMJMA5tqQSWXEqjDTncMuyCdEaoDBobiwJikRgSDuWJOQiW4UFgTwY7QxXruIqfvJZTRzmPx0PdugLQsVmkuBVa0gnwN-pxKydDZRY5zl38twXalza6c2JUTa2qx0mZ5bTvbzF9O5xC2TRtPNT_f5K5413fZDT6WLcYoEVLLit2uMagufiJkW3yEwUOIGfxoQ4r_7_EHLL-HbQ</recordid><startdate>19960909</startdate><enddate>19960909</enddate><creator>Maes, Michael</creator><creator>Van der Planken, Marc</creator><creator>Van Gastel, Ann</creator><creator>Desnyder, Roger</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960909</creationdate><title>Blood coagulation and platelet aggregation in major depression</title><author>Maes, Michael ; Van der Planken, Marc ; Van Gastel, Ann ; Desnyder, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-ef59bd3b8526466e2a0a8f30ad6a957fe3e920d336295d90473a6e8f345708153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>ADP</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aggregation</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation</topic><topic>Collagen</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Partial Thromboplastin Time</topic><topic>Platelet</topic><topic>Platelet Aggregation - physiology</topic><topic>Prothrombin Time</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reference Values</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Van der Planken, Marc</creatorcontrib><creatorcontrib>Van Gastel, Ann</creatorcontrib><creatorcontrib>Desnyder, Roger</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maes, Michael</au><au>Van der Planken, Marc</au><au>Van Gastel, Ann</au><au>Desnyder, Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood coagulation and platelet aggregation in major depression</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1996-09-09</date><risdate>1996</risdate><volume>40</volume><issue>1</issue><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Recently, it was found that the plasma of depressed patients significantly reduced the primary and secondary platelet aggregation to aggregating agents, such as ADP and collagen, in platelet rich plasma (PRP) of normal volunteers. Other authors found significantly decreased maximum amplitudes of adrenaline-induced platelet aggregation in major depressed patients versus normal controls. The aim of the present study was to examine platelet aggregation and blood coagulation in depression. Toward this end, the authors have measured secondary platelet aggregation to ADP and collagen, and the activated partial thromboplastin time (APTT) and prothrombin time (PT) in 16 normal volunteers, 16 minor, 40 simple major and 23 melancholic subjects. There were no significant differences in ADP- or collagen-induced platelet aggregability, APTT or PT between normal controls, minor, simple major or melancholic depressed patients. There were no significant relationships between severity of depression and APTT, PT or platelet aggregability to ADP or collagen. It is concluded that blood coagulation and platelet aggregability to ADP and collagen are probably not disordered in major depression.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8882912</pmid><doi>10.1016/0165-0327(96)00044-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of affective disorders, 1996-09, Vol.40 (1), p.35-40 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | ADP Adult Adult and adolescent clinical studies Aged Aggregation Biological and medical sciences Blood coagulation Collagen Depression Depressive Disorder - blood Depressive Disorder - diagnosis Female Humans Male Medical sciences Middle Aged Mood disorders Partial Thromboplastin Time Platelet Platelet Aggregation - physiology Prothrombin Time Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Serotonin |
| title | Blood coagulation and platelet aggregation in major depression |
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