Mineralocorticoid Action: Target Tissue Specificity is Enzyme, not Receptor, Mediated
Mineralocorticoid receptors, both when in tissue extracts and when recombinantderived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are f...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1988-10, Vol.242 (4878), p.583-585 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 585 |
|---|---|
| container_issue | 4878 |
| container_start_page | 583 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 242 |
| creator | Funder, John W. Pearce, Paul T. Smith, Robin Smith, A. Ian |
| description | Mineralocorticoid receptors, both when in tissue extracts and when recombinantderived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11$\beta $-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralcorticoid receptors. |
| doi_str_mv | 10.1126/science.2845584 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_78463449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A6819496</galeid><jstor_id>1702065</jstor_id><sourcerecordid>A6819496</sourcerecordid><originalsourceid>FETCH-LOGICAL-c698t-c56fa1a5b14c4ce878530014fafcfebd40ea247b2f212b1e4c1d0009dc24051c3</originalsourceid><addsrcrecordid>eNqN0u9rEzEYB_BDlFmnr32jcIjoi7Vbft7lfFfLrIPOgut8G9Lck5JxvdQkB9a_3pQe29TBSl4E8nyS8CTfLHuN0SnGpDgL2kKr4ZQIxrlgT7IBRhUfVQTRp9kAIVqMBCr58-xFCDcIpVpFj7Kjng-y60vbgleN085Hq52t87GO1rWf8oXyK4j5wobQQX61AW2N1TZucxvy8_b3dg3DvHUx_w4aNtH5YX4JtVUR6pfZM6OaAK_6-Ti7_nK-mHwdzebTi8l4NtJFJeJI88IorPgSM800iFJwihBmRhltYFkzBIqwckkMwWSJgWlc73qoNWGIY02Psw_7czfe_ewgRLm2QUPTqBZcF2QpWEEZqx6FlBNeCkQfhZgjwRgVCb77B964zrepW0kw5bRgvEjoZI9WqgFpW-OiV3oF-ydvwdi0PC4Erli108MHdBo1rNPX_M8__sWTiPArrlQXgry4-naonP84VH6eHijFdHZfnjwktWsaWIFMgZjM7-uzvdbeheDByI23a-W3EiO5i7zsIy_7DKcdb_uf6JZrqG_9Xf19X1dBq8Z41WobblmJuCgrlNibPbsJKct3t5aIoILTP3aBDww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213536456</pqid></control><display><type>article</type><title>Mineralocorticoid Action: Target Tissue Specificity is Enzyme, not Receptor, Mediated</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Funder, John W. ; Pearce, Paul T. ; Smith, Robin ; Smith, A. Ian</creator><creatorcontrib>Funder, John W. ; Pearce, Paul T. ; Smith, Robin ; Smith, A. Ian</creatorcontrib><description>Mineralocorticoid receptors, both when in tissue extracts and when recombinantderived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11$\beta $-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralcorticoid receptors.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2845584</identifier><identifier>PMID: 2845584</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Adrenalectomy ; Aldosterone ; Aldosterone - physiology ; Aldosterone assay ; Animals ; Biochemistry ; Biological and medical sciences ; Body tissues ; Carbenoxolone - pharmacology ; Cell regulation ; Cellular control mechanisms ; Colon - physiology ; Corticosterone ; Corticosterone - metabolism ; Cytosol ; Dehydrogenases ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids ; Heart - physiology ; Hippocampus - physiology ; Hormone receptors ; Hydrocortisone ; Hydrocortisone - metabolism ; Hydroxysteroid Dehydrogenases - metabolism ; Kidney - physiology ; Kidneys ; Mineralocorticoids ; Parotid Gland - physiology ; Rats ; Receptors ; Receptors, Mineralocorticoid ; Receptors, Steroid - physiology ; Steroid hormones. Cholecalciferol derivatives ; Steroids ; Vertebrates: endocrinology</subject><ispartof>Science (American Association for the Advancement of Science), 1988-10, Vol.242 (4878), p.583-585</ispartof><rights>Copyright 1988 The American Association for the Advancement of Science</rights><rights>1989 INIST-CNRS</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Oct 28, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c698t-c56fa1a5b14c4ce878530014fafcfebd40ea247b2f212b1e4c1d0009dc24051c3</citedby><cites>FETCH-LOGICAL-c698t-c56fa1a5b14c4ce878530014fafcfebd40ea247b2f212b1e4c1d0009dc24051c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1702065$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1702065$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7058790$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2845584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Funder, John W.</creatorcontrib><creatorcontrib>Pearce, Paul T.</creatorcontrib><creatorcontrib>Smith, Robin</creatorcontrib><creatorcontrib>Smith, A. Ian</creatorcontrib><title>Mineralocorticoid Action: Target Tissue Specificity is Enzyme, not Receptor, Mediated</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Mineralocorticoid receptors, both when in tissue extracts and when recombinantderived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11$\beta $-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralcorticoid receptors.</description><subject>Adrenalectomy</subject><subject>Aldosterone</subject><subject>Aldosterone - physiology</subject><subject>Aldosterone assay</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Body tissues</subject><subject>Carbenoxolone - pharmacology</subject><subject>Cell regulation</subject><subject>Cellular control mechanisms</subject><subject>Colon - physiology</subject><subject>Corticosterone</subject><subject>Corticosterone - metabolism</subject><subject>Cytosol</subject><subject>Dehydrogenases</subject><subject>Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids</subject><subject>Heart - physiology</subject><subject>Hippocampus - physiology</subject><subject>Hormone receptors</subject><subject>Hydrocortisone</subject><subject>Hydrocortisone - metabolism</subject><subject>Hydroxysteroid Dehydrogenases - metabolism</subject><subject>Kidney - physiology</subject><subject>Kidneys</subject><subject>Mineralocorticoids</subject><subject>Parotid Gland - physiology</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors, Mineralocorticoid</subject><subject>Receptors, Steroid - physiology</subject><subject>Steroid hormones. Cholecalciferol derivatives</subject><subject>Steroids</subject><subject>Vertebrates: endocrinology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0u9rEzEYB_BDlFmnr32jcIjoi7Vbft7lfFfLrIPOgut8G9Lck5JxvdQkB9a_3pQe29TBSl4E8nyS8CTfLHuN0SnGpDgL2kKr4ZQIxrlgT7IBRhUfVQTRp9kAIVqMBCr58-xFCDcIpVpFj7Kjng-y60vbgleN085Hq52t87GO1rWf8oXyK4j5wobQQX61AW2N1TZucxvy8_b3dg3DvHUx_w4aNtH5YX4JtVUR6pfZM6OaAK_6-Ti7_nK-mHwdzebTi8l4NtJFJeJI88IorPgSM800iFJwihBmRhltYFkzBIqwckkMwWSJgWlc73qoNWGIY02Psw_7czfe_ewgRLm2QUPTqBZcF2QpWEEZqx6FlBNeCkQfhZgjwRgVCb77B964zrepW0kw5bRgvEjoZI9WqgFpW-OiV3oF-ydvwdi0PC4Erli108MHdBo1rNPX_M8__sWTiPArrlQXgry4-naonP84VH6eHijFdHZfnjwktWsaWIFMgZjM7-uzvdbeheDByI23a-W3EiO5i7zsIy_7DKcdb_uf6JZrqG_9Xf19X1dBq8Z41WobblmJuCgrlNibPbsJKct3t5aIoILTP3aBDww</recordid><startdate>19881028</startdate><enddate>19881028</enddate><creator>Funder, John W.</creator><creator>Pearce, Paul T.</creator><creator>Smith, Robin</creator><creator>Smith, A. Ian</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19881028</creationdate><title>Mineralocorticoid Action: Target Tissue Specificity is Enzyme, not Receptor, Mediated</title><author>Funder, John W. ; Pearce, Paul T. ; Smith, Robin ; Smith, A. Ian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c698t-c56fa1a5b14c4ce878530014fafcfebd40ea247b2f212b1e4c1d0009dc24051c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adrenalectomy</topic><topic>Aldosterone</topic><topic>Aldosterone - physiology</topic><topic>Aldosterone assay</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Body tissues</topic><topic>Carbenoxolone - pharmacology</topic><topic>Cell regulation</topic><topic>Cellular control mechanisms</topic><topic>Colon - physiology</topic><topic>Corticosterone</topic><topic>Corticosterone - metabolism</topic><topic>Cytosol</topic><topic>Dehydrogenases</topic><topic>Enzymes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids</topic><topic>Heart - physiology</topic><topic>Hippocampus - physiology</topic><topic>Hormone receptors</topic><topic>Hydrocortisone</topic><topic>Hydrocortisone - metabolism</topic><topic>Hydroxysteroid Dehydrogenases - metabolism</topic><topic>Kidney - physiology</topic><topic>Kidneys</topic><topic>Mineralocorticoids</topic><topic>Parotid Gland - physiology</topic><topic>Rats</topic><topic>Receptors</topic><topic>Receptors, Mineralocorticoid</topic><topic>Receptors, Steroid - physiology</topic><topic>Steroid hormones. Cholecalciferol derivatives</topic><topic>Steroids</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Funder, John W.</creatorcontrib><creatorcontrib>Pearce, Paul T.</creatorcontrib><creatorcontrib>Smith, Robin</creatorcontrib><creatorcontrib>Smith, A. Ian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Funder, John W.</au><au>Pearce, Paul T.</au><au>Smith, Robin</au><au>Smith, A. Ian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mineralocorticoid Action: Target Tissue Specificity is Enzyme, not Receptor, Mediated</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1988-10-28</date><risdate>1988</risdate><volume>242</volume><issue>4878</issue><spage>583</spage><epage>585</epage><pages>583-585</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Mineralocorticoid receptors, both when in tissue extracts and when recombinantderived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11$\beta $-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralcorticoid receptors.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>2845584</pmid><doi>10.1126/science.2845584</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-10, Vol.242 (4878), p.583-585 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78463449 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adrenalectomy Aldosterone Aldosterone - physiology Aldosterone assay Animals Biochemistry Biological and medical sciences Body tissues Carbenoxolone - pharmacology Cell regulation Cellular control mechanisms Colon - physiology Corticosterone Corticosterone - metabolism Cytosol Dehydrogenases Enzymes Fundamental and applied biological sciences. Psychology Glucocorticoids Heart - physiology Hippocampus - physiology Hormone receptors Hydrocortisone Hydrocortisone - metabolism Hydroxysteroid Dehydrogenases - metabolism Kidney - physiology Kidneys Mineralocorticoids Parotid Gland - physiology Rats Receptors Receptors, Mineralocorticoid Receptors, Steroid - physiology Steroid hormones. Cholecalciferol derivatives Steroids Vertebrates: endocrinology |
| title | Mineralocorticoid Action: Target Tissue Specificity is Enzyme, not Receptor, Mediated |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A06%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mineralocorticoid%20Action:%20Target%20Tissue%20Specificity%20is%20Enzyme,%20not%20Receptor,%20Mediated&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Funder,%20John%20W.&rft.date=1988-10-28&rft.volume=242&rft.issue=4878&rft.spage=583&rft.epage=585&rft.pages=583-585&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.2845584&rft_dat=%3Cgale_proqu%3EA6819496%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213536456&rft_id=info:pmid/2845584&rft_galeid=A6819496&rft_jstor_id=1702065&rfr_iscdi=true |