Genetic Linkage Analysis of Autosomal Dominant Congenital Cataracts with Lens-specific DNA Probes and Polymorphic Phenotypic Markers

The authors studied a four-generation family with autosomal dominant congenital cataracts (ADCCs) using linkage analysis with 23 polymorphic phenotypic markers and DNA restriction fragment length polymorphisms (RFLPs) detected by lens-specific DNA probes. A total of 19 family members were studied an...

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Veröffentlicht in:	Ophthalmology (Rochester, Minn.) Minn.), 1988-04, Vol.95 (4), p.538-544
Hauptverfasser:	Barrett, David J., Sparkes, Robert S., Gorin, Michael B., Bhat, Suraj P., Spence, M. Anne, Marazita, Mary L., Bateman, J. Bronwyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquaporins autosomal dominant congenital cataract Biological and medical sciences Cataract - congenital Cataract - genetics Cataract - pathology congenital cataract crystallins Crystallins - genetics DNA Probes Eye Proteins - genetics Female Genes, Dominant Genetic Linkage Genetic Markers Humans Lens diseases Lens, Crystalline - metabolism Lens, Crystalline - physiology linkage analysis Male Medical sciences Membrane Glycoproteins MIP Ophthalmology Pedigree Phenotype RFLP
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