2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation

Suspensions of thymocytes from young rats were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which resulted in a sustained increase in cytosolic free Ca2+ concentration followed by DNA fragmentation and loss of cell viability. Both the Ca2+ increase and DNA fragmentation were prevented...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1988-10, Vol.242 (4876), p.256-259
Hauptverfasser:	MCCONKEY, D. J, HARTZELL, P, DUDDY, S. K, HAKANSSON, H, ORRENIUS, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines Animals Biochemistry Biological and medical sciences Calcium - metabolism Calcium - pharmacology Cell Survival - drug effects Cycloheximide - pharmacology Cytosol - metabolism Deoxyribonuclease I - metabolism Dioxins - pharmacology DNA - metabolism Enzyme Activation - drug effects Fluorescent Dyes Fundamental and applied biological sciences. Psychology Fundamental immunology Genetics Glucocorticoids - pharmacology Kinetics Polychlorinated Dibenzodioxins - pharmacology Rats T-Lymphocytes - drug effects Thymus Gland - drug effects Thymus Gland - metabolism
Online-Zugang:	Volltext
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