Inhibitors of P-Glycoprotein-Mediated Daunomycin Transport in Rat Liver Canalicular Membrane Vesicles

P-glycoprotein (P-gp), the multidrug resistance (MDR) gene product, is exclusively located on the canalicular membrane of hepato-cytes. Recent studies using isolated rat canalicular liver plasma membrane (cLPM) vesicles indicate that daunomycin (DNM) is a substrate for the ATP-dependent P-gp efflux...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1996-09, Vol.85 (9), p.935-939
Hauptverfasser:	Kwon, Younggil, Kamath, Amrita V., Morris, Marilyn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Antibiotics, Antineoplastic - pharmacokinetics Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Bile Canaliculi - metabolism Biological and medical sciences Biological Transport Chemotherapy Daunorubicin - pharmacokinetics Male Medical sciences Pharmacology. Drug treatments Propranolol - pharmacology Rats Rats, Sprague-Dawley Verapamil - pharmacology
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