Identification of Specific Residues of Human Interleukin 2 that Affect Binding to the 70-kDa Subunit (p70) of the Interleukin 2 Receptor

Analogs of interleukin 2 containing defined amino acid substitutions and deletions were assayed for bioactivity and for competitive binding to the high-affinity human interleukin 2 receptor complex and its two component subunits, a 55-kDa subunit (p55 or TAC) and a 70-kDa subunit (p70). Substitution...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-10, Vol.85 (20), p.7709-7713
Hauptverfasser:	Collins, L., W.-H. Tsien, Seals, C., Hakimi, J., Weber, D., Bailon, P., Hoskings, J., Greene, W. C., Toome, V., Ju, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis of the immune response. Humoral and cellular immunity B lymphocytes Binding, Competitive Biological and medical sciences Cell Line Cell lines Chromatography, Affinity Circular Dichroism Competitive binding Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interleukin-2 - analysis Interleukin-2 - genetics Interleukin-2 - immunology Interleukins Lymphocytes Lymphokines, interleukins ( function, expression) Mice Mutation Natural killer cells Receptors Receptors, Interleukin-2 - metabolism Recombinant Proteins - genetics Recombinant Proteins - immunology Regulatory factors and their cellular receptors T lymphocytes
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