Membrane-solvent-solute interaction in a model permeation system
In this study, methyl‐ and propylparaben flux from various alcohol donors through polydimethylsiloxane membranes was investigated. Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure of solvent membrane interaction,...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1988-06, Vol.77 (6), p.536-540 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Twist, John N. Zatz, Joel L. |
| description | In this study, methyl‐ and propylparaben flux from various alcohol donors through polydimethylsiloxane membranes was investigated. Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure of solvent membrane interaction, gave a good rank order correlation to the flux data for a particular paraben. The major influence of the alcohols was an increase in membrane solubility of paraben, with a smaller effect on the diffusion coefficient. High paraben donor solubility indirectly reduced the solvent–membrane interaction leading to attenuated flux. Paraben membrane solubility was influenced by the amount of alcohol sorbed from saturated systems and the affinity of the paraben for the alcohol. This conforms to the concept of imbibed alcohol molecules being organized into clusters. The alteration in barrier properties of the membrane was found to require the presence of sorbed alcohol and was reversible upon removal of the solvent. |
| doi_str_mv | 10.1002/jps.2600770616 |
| format | Article |
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Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure of solvent membrane interaction, gave a good rank order correlation to the flux data for a particular paraben. The major influence of the alcohols was an increase in membrane solubility of paraben, with a smaller effect on the diffusion coefficient. High paraben donor solubility indirectly reduced the solvent–membrane interaction leading to attenuated flux. Paraben membrane solubility was influenced by the amount of alcohol sorbed from saturated systems and the affinity of the paraben for the alcohol. This conforms to the concept of imbibed alcohol molecules being organized into clusters. The alteration in barrier properties of the membrane was found to require the presence of sorbed alcohol and was reversible upon removal of the solvent.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600770616</identifier><identifier>PMID: 3171936</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Alcohols - analysis ; Biological and medical sciences ; Dimethylpolysiloxanes ; General pharmacology ; Medical sciences ; membranes ; Membranes, Artificial ; Models, Biological ; Parabens ; Permeability ; Pharmacology. Drug treatments ; Physicochemical properties. 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Pharm. Sci</addtitle><description>In this study, methyl‐ and propylparaben flux from various alcohol donors through polydimethylsiloxane membranes was investigated. Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure of solvent membrane interaction, gave a good rank order correlation to the flux data for a particular paraben. The major influence of the alcohols was an increase in membrane solubility of paraben, with a smaller effect on the diffusion coefficient. High paraben donor solubility indirectly reduced the solvent–membrane interaction leading to attenuated flux. Paraben membrane solubility was influenced by the amount of alcohol sorbed from saturated systems and the affinity of the paraben for the alcohol. This conforms to the concept of imbibed alcohol molecules being organized into clusters. The alteration in barrier properties of the membrane was found to require the presence of sorbed alcohol and was reversible upon removal of the solvent.</description><subject>Alcohols - analysis</subject><subject>Biological and medical sciences</subject><subject>Dimethylpolysiloxanes</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>membranes</subject><subject>Membranes, Artificial</subject><subject>Models, Biological</subject><subject>Parabens</subject><subject>Permeability</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>Solubility</subject><subject>Solvents</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1PwzAQxS0EKqWwsiF1QGwpZzu2kw1UQQGVL_G5WY5zkVKSpsQJ0P8el1btyHS23-_urPcIOaQwoADsdDJzAyYBlAJJ5RbpUsEgkEDVNul6gAVchPEu2XNuAgAShOiQDqeKxlx2ydktlkltphi4qvjCabOobYP9fNpgbWyTV1N_7pt-WaVY9GdYl2j-Xt3cNVjuk53MFA4PVrVHXi4vnodXwfh-dD08Hwe53y8DnmRhmBmDNmEUWZpEgofSZsomIhYKY5YqZkWolIxCwyGjJksV5bGFCGxieI-cLOfO6uqzRdfoMncWi8L_vWqdVlEoIlD8X5AK6o2LmAePVmCblJjqWZ2Xpp7rlTdeP17pxllTZN4lm7s15hcyGoPH4iX2nRc4X8sU9CIf7fPRm3z0zcPT5uZ7g2Vv7q38Wfea-kNLxZXQb3cjDQLg_ZFF-pX_Ar-qklc</recordid><startdate>198806</startdate><enddate>198806</enddate><creator>Twist, John N.</creator><creator>Zatz, Joel L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198806</creationdate><title>Membrane-solvent-solute interaction in a model permeation system</title><author>Twist, John N. ; Zatz, Joel L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3546-3bf44faaecb21e2db85346cf7cb5957e92d72c5477684a30f1afd7139c080cba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alcohols - analysis</topic><topic>Biological and medical sciences</topic><topic>Dimethylpolysiloxanes</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>membranes</topic><topic>Membranes, Artificial</topic><topic>Models, Biological</topic><topic>Parabens</topic><topic>Permeability</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Solubility</topic><topic>Solvents</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Twist, John N.</creatorcontrib><creatorcontrib>Zatz, Joel L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Twist, John N.</au><au>Zatz, Joel L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Membrane-solvent-solute interaction in a model permeation system</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1988-06</date><risdate>1988</risdate><volume>77</volume><issue>6</issue><spage>536</spage><epage>540</epage><pages>536-540</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>In this study, methyl‐ and propylparaben flux from various alcohol donors through polydimethylsiloxane membranes was investigated. Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure of solvent membrane interaction, gave a good rank order correlation to the flux data for a particular paraben. The major influence of the alcohols was an increase in membrane solubility of paraben, with a smaller effect on the diffusion coefficient. High paraben donor solubility indirectly reduced the solvent–membrane interaction leading to attenuated flux. Paraben membrane solubility was influenced by the amount of alcohol sorbed from saturated systems and the affinity of the paraben for the alcohol. This conforms to the concept of imbibed alcohol molecules being organized into clusters. The alteration in barrier properties of the membrane was found to require the presence of sorbed alcohol and was reversible upon removal of the solvent.</abstract><cop>Washington</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3171936</pmid><doi>10.1002/jps.2600770616</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1988-06, Vol.77 (6), p.536-540 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Alcohols - analysis Biological and medical sciences Dimethylpolysiloxanes General pharmacology Medical sciences membranes Membranes, Artificial Models, Biological Parabens Permeability Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Solubility Solvents Spectrophotometry, Ultraviolet |
| title | Membrane-solvent-solute interaction in a model permeation system |
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