Mouse ovarian tumor cells: An experimental model for progestin-mediated radiotherapy

Mouse ovarian tumor (MOT) cells have been grown in C3HeB/FeJ mice as an ascites and as a subcutaneous tumor and in cell culture as a suspension. These cells contain saturable, high‐affinity, specific progesterone receptors. Estrogen receptors were not detectable in these cells. MOT cells can be used...

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Veröffentlicht in:	Journal of surgical oncology 1988-10, Vol.39 (2), p.96-100
Hauptverfasser:	Blumenthal, Rosalyn D., McLaughlin, William H., Jordan, Jerold J., Cryan, Ellen V., Bloomer, William D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals ascites tumor Biological and medical sciences Disease Models, Animal Experimental genital and mammary tumors Female Medical sciences Mice Mice, Inbred C3H Ovarian Neoplasms - analysis Ovarian Neoplasms - pathology Ovarian Neoplasms - radiotherapy progesterone binding receptor-mediated radiotherapy Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tumor Cells, Cultured Tumors
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Beschreibung
Zusammenfassung:	Mouse ovarian tumor (MOT) cells have been grown in C3HeB/FeJ mice as an ascites and as a subcutaneous tumor and in cell culture as a suspension. These cells contain saturable, high‐affinity, specific progesterone receptors. Estrogen receptors were not detectable in these cells. MOT cells can be used as both an in vivo and an in vitro model for progestin‐mediated radiotherapy.
ISSN:	0022-4790 1096-9098
DOI:	10.1002/jso.2930390206