Quantification of citrate concentration in the prostate by proton magnetic resonance spectroscopy: Zonal and age-related differences
A commercial phased‐array multicoil was used to acquire water‐suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal‐to‐noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate. Qu...
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| Veröffentlicht in: | Magnetic resonance in medicine 1996-09, Vol.36 (3), p.352-358 |
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| container_title | Magnetic resonance in medicine |
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| creator | Lowry, Martin Liney, G. P. Turnbull, L. W. Manton, D. J. Blackband, S. J. Horsman, A. |
| description | A commercial phased‐array multicoil was used to acquire water‐suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal‐to‐noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate. Quantification of the citrate peak using experimentally determined relaxation parameters with tissue water as an internal concentration reference revealed a marked variability between different volunteers. Nevertheless, in each case, the citrate concentration was up to fourfold greater in the peripheral zone than in the central gland. Furthermore, the difference in citrate concentration between these two regions was positively correlated with the subjects age. The results indicate a consistent difference in cellular function between the major anatomical regions within the prostate and may have important consequences for the application of magnetic resonance spectroscopy to the diagnosis of prostatic pathology. |
| doi_str_mv | 10.1002/mrm.1910360305 |
| format | Article |
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P. ; Turnbull, L. W. ; Manton, D. J. ; Blackband, S. J. ; Horsman, A.</creator><creatorcontrib>Lowry, Martin ; Liney, G. P. ; Turnbull, L. W. ; Manton, D. J. ; Blackband, S. J. ; Horsman, A.</creatorcontrib><description>A commercial phased‐array multicoil was used to acquire water‐suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal‐to‐noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate. Quantification of the citrate peak using experimentally determined relaxation parameters with tissue water as an internal concentration reference revealed a marked variability between different volunteers. Nevertheless, in each case, the citrate concentration was up to fourfold greater in the peripheral zone than in the central gland. Furthermore, the difference in citrate concentration between these two regions was positively correlated with the subjects age. The results indicate a consistent difference in cellular function between the major anatomical regions within the prostate and may have important consequences for the application of magnetic resonance spectroscopy to the diagnosis of prostatic pathology.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910360305</identifier><identifier>PMID: 8875404</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Biological and medical sciences ; citrate ; Citric Acid - analysis ; Digestive system ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Middle Aged ; prostate ; Prostate - metabolism ; Protons ; quantification ; Radiodiagnosis. Nmr imagery. 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P.</creatorcontrib><creatorcontrib>Turnbull, L. W.</creatorcontrib><creatorcontrib>Manton, D. J.</creatorcontrib><creatorcontrib>Blackband, S. J.</creatorcontrib><creatorcontrib>Horsman, A.</creatorcontrib><title>Quantification of citrate concentration in the prostate by proton magnetic resonance spectroscopy: Zonal and age-related differences</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>A commercial phased‐array multicoil was used to acquire water‐suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal‐to‐noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate. Quantification of the citrate peak using experimentally determined relaxation parameters with tissue water as an internal concentration reference revealed a marked variability between different volunteers. Nevertheless, in each case, the citrate concentration was up to fourfold greater in the peripheral zone than in the central gland. Furthermore, the difference in citrate concentration between these two regions was positively correlated with the subjects age. The results indicate a consistent difference in cellular function between the major anatomical regions within the prostate and may have important consequences for the application of magnetic resonance spectroscopy to the diagnosis of prostatic pathology.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>citrate</subject><subject>Citric Acid - analysis</subject><subject>Digestive system</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>prostate</subject><subject>Prostate - metabolism</subject><subject>Protons</subject><subject>quantification</subject><subject>Radiodiagnosis. Nmr imagery. 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Quantification of the citrate peak using experimentally determined relaxation parameters with tissue water as an internal concentration reference revealed a marked variability between different volunteers. Nevertheless, in each case, the citrate concentration was up to fourfold greater in the peripheral zone than in the central gland. Furthermore, the difference in citrate concentration between these two regions was positively correlated with the subjects age. The results indicate a consistent difference in cellular function between the major anatomical regions within the prostate and may have important consequences for the application of magnetic resonance spectroscopy to the diagnosis of prostatic pathology.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8875404</pmid><doi>10.1002/mrm.1910360305</doi><tpages>7</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1996-09, Vol.36 (3), p.352-358 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Biological and medical sciences citrate Citric Acid - analysis Digestive system Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged prostate Prostate - metabolism Protons quantification Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | Quantification of citrate concentration in the prostate by proton magnetic resonance spectroscopy: Zonal and age-related differences |
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