9-Benzyl-6-(dimethylamino)-9H-purines with antirhinovirus activity

A series of 9-benzyl-6-(dimethylamino)-9H-purines and 9-benzyl-2-chloro-6-(dimethylamino)-9H-purines were synthesized and tested in cell culture for activity against rhinovirus type 1B. The 9-benzylpurines that were unsubstituted in the 2-position had weak activity. However, introduction of a 2-chlo...

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Veröffentlicht in:	Journal of medicinal chemistry 1988-10, Vol.31 (10), p.2001-2004
Hauptverfasser:	Kelley, James L, Linn, James A, Krochmal, Mark P, Selway, J. W. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - pharmacology Antiviral Agents - pharmacology Chemistry Cytopathogenic Effect, Viral Exact sciences and technology HeLa Cells - drug effects Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Humans Organic chemistry Preparations and properties Purines - pharmacology rhinovirus Rhinovirus - drug effects Structure-Activity Relationship
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