Colorectal carcinoma and brain metastasis: distribution, treatment, and survival
Brain metastasis from colorectal cancer is rare. The present study reports the nature of this disease and analyzes factors correlated with survival in patients harboring such disease. One hundred patients diagnosed between 1980 and 1994 with metastatic brain tumors secondary to colorectal adenocarci...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 1996-09, Vol.3 (5), p.453-463 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 463 |
|---|---|
| container_issue | 5 |
| container_start_page | 453 |
| container_title | Annals of surgical oncology |
| container_volume | 3 |
| creator | Hammoud, M A McCutcheon, I E Elsouki, R Schoppa, D Patt, Y Z |
| description | Brain metastasis from colorectal cancer is rare. The present study reports the nature of this disease and analyzes factors correlated with survival in patients harboring such disease.
One hundred patients diagnosed between 1980 and 1994 with metastatic brain tumors secondary to colorectal adenocarcinoma were retrospectively reviewed. Of these patients, 36 underwent surgery, 57 underwent radiotherapy alone, and the remaining seven received steroids.
The most common primary sites were the sigmoid colon and rectum (65%). Brain metastases with concomitant liver and/or lung metastases were seen more frequently than brain metastases alone. The median interval between the diagnosis of primary cancer and the diagnosis of brain metastasis was 26 months (95% confidence interval = 22-30). The median survival time after the diagnosis of brain metastasis was 1 month for patients who received only steroids, 3 months for those who received radiotherapy (p = 0.1), and 9 months for those who underwent surgery (p < 0.0001). The extent of noncerebral systemic disease was not correlated with survival (p > 0.05), but early onset of brain metastasis was significantly associated with poor prognosis (p = 0.04).
Surgical removal of colorectal metastatic brain lesions results in significantly increased survival time, regardless of the status of the noncerebral systemic disease. |
| doi_str_mv | 10.1007/bf02305763 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78455087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78455087</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-6ccbe9236a182a4733a166ee2a0f50e6a2529469044a61eaa446cd21c13310473</originalsourceid><addsrcrecordid>eNo90E1Lw0AQBuBFlFqrF-9CTh6k0f3KZuOtFqtCQQ96DpPNBFaSbN3dFPz3prYKM8wcHt7DS8glo7eM0vyuaigXNMuVOCJTlgmZSqXZ8fhTpdOCq-yUnIXwSSnLRzchE61zNe6UvC1d6zyaCG1iwBvbuw4S6Ouk8mD7pMMIYRwb7pPahuhtNUTr-nkSPULssI_zXx4Gv7VbaM_JSQNtwIvDnZGP1eP78jldvz69LBfr1AipY6qMqbDgQgHTHGQuBDClEDnQJqOogGe8kKqgUoJiCCClMjVnhgnB6Ohn5Hqfu_Hua8AQy84Gg20LPbohlLmWWUb1Dt7sofEuBI9NufG2A_9dMlru6isfVn_1jfjqkDpUHdb_9NCX-AH31mnX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78455087</pqid></control><display><type>article</type><title>Colorectal carcinoma and brain metastasis: distribution, treatment, and survival</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Hammoud, M A ; McCutcheon, I E ; Elsouki, R ; Schoppa, D ; Patt, Y Z</creator><creatorcontrib>Hammoud, M A ; McCutcheon, I E ; Elsouki, R ; Schoppa, D ; Patt, Y Z</creatorcontrib><description>Brain metastasis from colorectal cancer is rare. The present study reports the nature of this disease and analyzes factors correlated with survival in patients harboring such disease.
One hundred patients diagnosed between 1980 and 1994 with metastatic brain tumors secondary to colorectal adenocarcinoma were retrospectively reviewed. Of these patients, 36 underwent surgery, 57 underwent radiotherapy alone, and the remaining seven received steroids.
The most common primary sites were the sigmoid colon and rectum (65%). Brain metastases with concomitant liver and/or lung metastases were seen more frequently than brain metastases alone. The median interval between the diagnosis of primary cancer and the diagnosis of brain metastasis was 26 months (95% confidence interval = 22-30). The median survival time after the diagnosis of brain metastasis was 1 month for patients who received only steroids, 3 months for those who received radiotherapy (p = 0.1), and 9 months for those who underwent surgery (p < 0.0001). The extent of noncerebral systemic disease was not correlated with survival (p > 0.05), but early onset of brain metastasis was significantly associated with poor prognosis (p = 0.04).
Surgical removal of colorectal metastatic brain lesions results in significantly increased survival time, regardless of the status of the noncerebral systemic disease.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1007/bf02305763</identifier><identifier>PMID: 8876887</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - secondary ; Adenocarcinoma - therapy ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms - mortality ; Brain Neoplasms - secondary ; Brain Neoplasms - therapy ; Chemotherapy, Adjuvant ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - therapy ; Female ; Humans ; Incidence ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multivariate Analysis ; Proportional Hazards Models ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Rate</subject><ispartof>Annals of surgical oncology, 1996-09, Vol.3 (5), p.453-463</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-6ccbe9236a182a4733a166ee2a0f50e6a2529469044a61eaa446cd21c13310473</citedby><cites>FETCH-LOGICAL-c348t-6ccbe9236a182a4733a166ee2a0f50e6a2529469044a61eaa446cd21c13310473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8876887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammoud, M A</creatorcontrib><creatorcontrib>McCutcheon, I E</creatorcontrib><creatorcontrib>Elsouki, R</creatorcontrib><creatorcontrib>Schoppa, D</creatorcontrib><creatorcontrib>Patt, Y Z</creatorcontrib><title>Colorectal carcinoma and brain metastasis: distribution, treatment, and survival</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><description>Brain metastasis from colorectal cancer is rare. The present study reports the nature of this disease and analyzes factors correlated with survival in patients harboring such disease.
One hundred patients diagnosed between 1980 and 1994 with metastatic brain tumors secondary to colorectal adenocarcinoma were retrospectively reviewed. Of these patients, 36 underwent surgery, 57 underwent radiotherapy alone, and the remaining seven received steroids.
The most common primary sites were the sigmoid colon and rectum (65%). Brain metastases with concomitant liver and/or lung metastases were seen more frequently than brain metastases alone. The median interval between the diagnosis of primary cancer and the diagnosis of brain metastasis was 26 months (95% confidence interval = 22-30). The median survival time after the diagnosis of brain metastasis was 1 month for patients who received only steroids, 3 months for those who received radiotherapy (p = 0.1), and 9 months for those who underwent surgery (p < 0.0001). The extent of noncerebral systemic disease was not correlated with survival (p > 0.05), but early onset of brain metastasis was significantly associated with poor prognosis (p = 0.04).
Surgical removal of colorectal metastatic brain lesions results in significantly increased survival time, regardless of the status of the noncerebral systemic disease.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - secondary</subject><subject>Brain Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1Lw0AQBuBFlFqrF-9CTh6k0f3KZuOtFqtCQQ96DpPNBFaSbN3dFPz3prYKM8wcHt7DS8glo7eM0vyuaigXNMuVOCJTlgmZSqXZ8fhTpdOCq-yUnIXwSSnLRzchE61zNe6UvC1d6zyaCG1iwBvbuw4S6Ouk8mD7pMMIYRwb7pPahuhtNUTr-nkSPULssI_zXx4Gv7VbaM_JSQNtwIvDnZGP1eP78jldvz69LBfr1AipY6qMqbDgQgHTHGQuBDClEDnQJqOogGe8kKqgUoJiCCClMjVnhgnB6Ohn5Hqfu_Hua8AQy84Gg20LPbohlLmWWUb1Dt7sofEuBI9NufG2A_9dMlru6isfVn_1jfjqkDpUHdb_9NCX-AH31mnX</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>Hammoud, M A</creator><creator>McCutcheon, I E</creator><creator>Elsouki, R</creator><creator>Schoppa, D</creator><creator>Patt, Y Z</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960901</creationdate><title>Colorectal carcinoma and brain metastasis: distribution, treatment, and survival</title><author>Hammoud, M A ; McCutcheon, I E ; Elsouki, R ; Schoppa, D ; Patt, Y Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-6ccbe9236a182a4733a166ee2a0f50e6a2529469044a61eaa446cd21c13310473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - secondary</topic><topic>Brain Neoplasms - therapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammoud, M A</creatorcontrib><creatorcontrib>McCutcheon, I E</creatorcontrib><creatorcontrib>Elsouki, R</creatorcontrib><creatorcontrib>Schoppa, D</creatorcontrib><creatorcontrib>Patt, Y Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammoud, M A</au><au>McCutcheon, I E</au><au>Elsouki, R</au><au>Schoppa, D</au><au>Patt, Y Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colorectal carcinoma and brain metastasis: distribution, treatment, and survival</atitle><jtitle>Annals of surgical oncology</jtitle><addtitle>Ann Surg Oncol</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>3</volume><issue>5</issue><spage>453</spage><epage>463</epage><pages>453-463</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Brain metastasis from colorectal cancer is rare. The present study reports the nature of this disease and analyzes factors correlated with survival in patients harboring such disease.
One hundred patients diagnosed between 1980 and 1994 with metastatic brain tumors secondary to colorectal adenocarcinoma were retrospectively reviewed. Of these patients, 36 underwent surgery, 57 underwent radiotherapy alone, and the remaining seven received steroids.
The most common primary sites were the sigmoid colon and rectum (65%). Brain metastases with concomitant liver and/or lung metastases were seen more frequently than brain metastases alone. The median interval between the diagnosis of primary cancer and the diagnosis of brain metastasis was 26 months (95% confidence interval = 22-30). The median survival time after the diagnosis of brain metastasis was 1 month for patients who received only steroids, 3 months for those who received radiotherapy (p = 0.1), and 9 months for those who underwent surgery (p < 0.0001). The extent of noncerebral systemic disease was not correlated with survival (p > 0.05), but early onset of brain metastasis was significantly associated with poor prognosis (p = 0.04).
Surgical removal of colorectal metastatic brain lesions results in significantly increased survival time, regardless of the status of the noncerebral systemic disease.</abstract><cop>United States</cop><pmid>8876887</pmid><doi>10.1007/bf02305763</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 1996-09, Vol.3 (5), p.453-463 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78455087 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adenocarcinoma - mortality Adenocarcinoma - secondary Adenocarcinoma - therapy Adult Aged Aged, 80 and over Brain Neoplasms - mortality Brain Neoplasms - secondary Brain Neoplasms - therapy Chemotherapy, Adjuvant Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Female Humans Incidence Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Proportional Hazards Models Radiotherapy, Adjuvant Retrospective Studies Survival Rate |
| title | Colorectal carcinoma and brain metastasis: distribution, treatment, and survival |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T19%3A31%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Colorectal%20carcinoma%20and%20brain%20metastasis:%20distribution,%20treatment,%20and%20survival&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Hammoud,%20M%20A&rft.date=1996-09-01&rft.volume=3&rft.issue=5&rft.spage=453&rft.epage=463&rft.pages=453-463&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1007/bf02305763&rft_dat=%3Cproquest_cross%3E78455087%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78455087&rft_id=info:pmid/8876887&rfr_iscdi=true |