Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin ®)
The fate of 14C-labelled PSK in the body was investigated. Although only substances with low mol. wt were observed in blood shortly after the administration, with time, substances with high mol. wt appeared, suggesting absorption of PSK in its original form from the digestive tract. 14C-labelled PSK...
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| Veröffentlicht in: | International journal of immunopharmacology 1988, Vol.10 (4), p.415-423 |
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| container_title | International journal of immunopharmacology |
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| creator | IKUZAWA, M MATSUNAGA, K YOSHIKUMI, C NISHIYAMA, S NAKAJIMA, S KOBAYASHI, Y ANDOH, T KOBAYASHI, A OHHARA, M OHMURA, Y WADA, T |
| description | The fate of
14C-labelled PSK in the body was investigated. Although only substances with low mol. wt were observed in blood shortly after the administration, with time, substances with high mol. wt appeared, suggesting absorption of PSK in its original form from the digestive tract.
14C-labelled PSK was distributed in bone marrow, salivary gland, brain, liver, spleen, pancreas and tumor. Approximately 70% of
14C-labelled PSK was excreted by expiratory air after 24 h and approximately 15–20% in urine after 72 h. Only a small amount of
14C-labelled PSK was transferred into lymph and bile. The present study on the
in vivo behavior of PSK provides an important basis for further analysis of its pharmacological actions. |
| doi_str_mv | 10.1016/0192-0561(88)90128-2 |
| format | Article |
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14C-labelled PSK in the body was investigated. Although only substances with low mol. wt were observed in blood shortly after the administration, with time, substances with high mol. wt appeared, suggesting absorption of PSK in its original form from the digestive tract.
14C-labelled PSK was distributed in bone marrow, salivary gland, brain, liver, spleen, pancreas and tumor. Approximately 70% of
14C-labelled PSK was excreted by expiratory air after 24 h and approximately 15–20% in urine after 72 h. Only a small amount of
14C-labelled PSK was transferred into lymph and bile. The present study on the
in vivo behavior of PSK provides an important basis for further analysis of its pharmacological actions.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(88)90128-2</identifier><identifier>PMID: 3170055</identifier><identifier>CODEN: IJIMDS</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Absorption ; Animals ; Antibiotics, Antineoplastic - pharmacokinetics ; Antibiotics, Antineoplastic - pharmacology ; Biological and medical sciences ; Immunomodulators ; Lymphatic System - metabolism ; Medical sciences ; Mice ; Mice, Inbred ICR ; Molecular Weight ; Pharmacology. Drug treatments ; Proteoglycans - pharmacokinetics ; Proteoglycans - pharmacology ; Rabbits ; Rats ; Tissue Distribution</subject><ispartof>International journal of immunopharmacology, 1988, Vol.10 (4), p.415-423</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-36855ecdb69347e4934ac7c4a2bfebf2d0757811336022a345fe1d4b0ee215b3</citedby><cites>FETCH-LOGICAL-c452t-36855ecdb69347e4934ac7c4a2bfebf2d0757811336022a345fe1d4b0ee215b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7002969$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3170055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IKUZAWA, M</creatorcontrib><creatorcontrib>MATSUNAGA, K</creatorcontrib><creatorcontrib>YOSHIKUMI, C</creatorcontrib><creatorcontrib>NISHIYAMA, S</creatorcontrib><creatorcontrib>NAKAJIMA, S</creatorcontrib><creatorcontrib>KOBAYASHI, Y</creatorcontrib><creatorcontrib>ANDOH, T</creatorcontrib><creatorcontrib>KOBAYASHI, A</creatorcontrib><creatorcontrib>OHHARA, M</creatorcontrib><creatorcontrib>OHMURA, Y</creatorcontrib><creatorcontrib>WADA, T</creatorcontrib><title>Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin ®)</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>The fate of
14C-labelled PSK in the body was investigated. Although only substances with low mol. wt were observed in blood shortly after the administration, with time, substances with high mol. wt appeared, suggesting absorption of PSK in its original form from the digestive tract.
14C-labelled PSK was distributed in bone marrow, salivary gland, brain, liver, spleen, pancreas and tumor. Approximately 70% of
14C-labelled PSK was excreted by expiratory air after 24 h and approximately 15–20% in urine after 72 h. Only a small amount of
14C-labelled PSK was transferred into lymph and bile. The present study on the
in vivo behavior of PSK provides an important basis for further analysis of its pharmacological actions.</description><subject>Absorption</subject><subject>Animals</subject><subject>Antibiotics, Antineoplastic - pharmacokinetics</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Immunomodulators</subject><subject>Lymphatic System - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Molecular Weight</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteoglycans - pharmacokinetics</subject><subject>Proteoglycans - pharmacology</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Tissue Distribution</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKAzEQQIMotVb_QGEPInpYTbLJbvYiiFgVBYX2HrLJLEa2m5pkBX_Kj_DLTG3pUQjJkHkzmTyEjgm-JJiUV5jUNMe8JOdCXNSYUJHTHTQmoqrzgtV8F423yD46COEdY8xJSUdoVJAqxXyMZlMVIVO9yYwN0dtmiNb1mWvTXVrRxmHhfLb0LoLt88YNCV267isord-Utway19lTdv7kIUTbZz_fF4dor1VdgKPNOUHz6d389iF_frl_vL15zjXjNOZFKTgHbZqyLlgFLO1KV5op2rTQtNTgileCkKIoMaWqYLwFYliDASjhTTFBZ-u2abiPIb0uFzZo6DrVgxuCrATjLFUlkK1B7V0IHlq59Hah_JckWK5UypUnufIkhZB_KiVNZSeb_kOzALMt2rhL-dNNXgWtutarXtuwxRJE6_S1CbpeY5BUfFrwMmgLvQZjPegojbP_z_ELfiGPUQ</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>IKUZAWA, M</creator><creator>MATSUNAGA, K</creator><creator>YOSHIKUMI, C</creator><creator>NISHIYAMA, S</creator><creator>NAKAJIMA, S</creator><creator>KOBAYASHI, Y</creator><creator>ANDOH, T</creator><creator>KOBAYASHI, A</creator><creator>OHHARA, M</creator><creator>OHMURA, Y</creator><creator>WADA, T</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin ®)</title><author>IKUZAWA, M ; MATSUNAGA, K ; YOSHIKUMI, C ; NISHIYAMA, S ; NAKAJIMA, S ; KOBAYASHI, Y ; ANDOH, T ; KOBAYASHI, A ; OHHARA, M ; OHMURA, Y ; WADA, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-36855ecdb69347e4934ac7c4a2bfebf2d0757811336022a345fe1d4b0ee215b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Antibiotics, Antineoplastic - pharmacokinetics</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Immunomodulators</topic><topic>Lymphatic System - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Molecular Weight</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteoglycans - pharmacokinetics</topic><topic>Proteoglycans - pharmacology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IKUZAWA, M</creatorcontrib><creatorcontrib>MATSUNAGA, K</creatorcontrib><creatorcontrib>YOSHIKUMI, C</creatorcontrib><creatorcontrib>NISHIYAMA, S</creatorcontrib><creatorcontrib>NAKAJIMA, S</creatorcontrib><creatorcontrib>KOBAYASHI, Y</creatorcontrib><creatorcontrib>ANDOH, T</creatorcontrib><creatorcontrib>KOBAYASHI, A</creatorcontrib><creatorcontrib>OHHARA, M</creatorcontrib><creatorcontrib>OHMURA, Y</creatorcontrib><creatorcontrib>WADA, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKUZAWA, M</au><au>MATSUNAGA, K</au><au>YOSHIKUMI, C</au><au>NISHIYAMA, S</au><au>NAKAJIMA, S</au><au>KOBAYASHI, Y</au><au>ANDOH, T</au><au>KOBAYASHI, A</au><au>OHHARA, M</au><au>OHMURA, Y</au><au>WADA, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin ®)</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1988</date><risdate>1988</risdate><volume>10</volume><issue>4</issue><spage>415</spage><epage>423</epage><pages>415-423</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><coden>IJIMDS</coden><abstract>The fate of
14C-labelled PSK in the body was investigated. Although only substances with low mol. wt were observed in blood shortly after the administration, with time, substances with high mol. wt appeared, suggesting absorption of PSK in its original form from the digestive tract.
14C-labelled PSK was distributed in bone marrow, salivary gland, brain, liver, spleen, pancreas and tumor. Approximately 70% of
14C-labelled PSK was excreted by expiratory air after 24 h and approximately 15–20% in urine after 72 h. Only a small amount of
14C-labelled PSK was transferred into lymph and bile. The present study on the
in vivo behavior of PSK provides an important basis for further analysis of its pharmacological actions.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>3170055</pmid><doi>10.1016/0192-0561(88)90128-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | International journal of immunopharmacology, 1988, Vol.10 (4), p.415-423 |
| issn | 0192-0561 1879-3495 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Absorption Animals Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - pharmacology Biological and medical sciences Immunomodulators Lymphatic System - metabolism Medical sciences Mice Mice, Inbred ICR Molecular Weight Pharmacology. Drug treatments Proteoglycans - pharmacokinetics Proteoglycans - pharmacology Rabbits Rats Tissue Distribution |
| title | Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin ®) |
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