Volatile general anesthetics produce hyperpolarization of aplysia neurons by activation of a discrete population of baseline potassium channels

The mechanism by which volatile anesthetics act on neuronal tissue to produce reversible depression is unknown. Previous studies have identified a potassium current in invertebrate neurons that is activated by volatile anesthetics. The molecular components generating this current are characterized h...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1996-10, Vol.85 (4), p.889-900
Hauptverfasser:	WINEGAR, B. D, OWEN, D. F, YOST, C. S, FORSAYETH, J. R, MAYERI, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - administration & dosage Anesthetics, Inhalation - pharmacology Anesthetics. Neuromuscular blocking agents Animals Aplysia Biological and medical sciences Electrophysiology Ganglia, Invertebrate - drug effects Ganglia, Invertebrate - metabolism Halothane - administration & dosage Halothane - pharmacology Ion Channel Gating - drug effects Isoflurane - pharmacology Medical sciences Membrane Potentials - drug effects Neurons - drug effects Neurons - metabolism Neuropharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - metabolism Serotonin - pharmacology
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