Demonstration of potent lipid-lowering activity by a thyromimetic agent devoid of cardiovascular and thermogenic effects

A potent lipid-lowering thyromimetic (CGS 26214) devoid of cardiac and thermogenic activity was identified based on its ability to preferentially access and bind the nuclear fraction of hepatocytes over that of myocytes in culture. The difference in access achieved with CGS 26214 was at least 100-fo...

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Veröffentlicht in:	Atherosclerosis 1996-09, Vol.126 (1), p.53-63
Hauptverfasser:	Stephan, Zouhair F., Yurachek, Edna C., Sharif, Robin, Wasvary, Jong M., Leonards, Kenneth S., Hu, Chii-Whei, Hintze, Thomas H., Steele, Ronald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Anticholesteremic Agents - metabolism Anticholesteremic Agents - pharmacology Atherosclerosis Binding, Competitive Biological and medical sciences Body Temperature - drug effects Carcinoma, Hepatocellular - pathology Cardiac Output - drug effects Cardiovascular System - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Cholesterol Cholesterol - blood Dogs Drug Evaluation, Preclinical General and cellular metabolism. Vitamins Glyoxylates - metabolism Glyoxylates - pharmacology Heart - drug effects Hypercholesterolemia - blood Hypolipidemic Hypolipidemic Agents - metabolism Hypolipidemic Agents - pharmacology L-T 3 LDL Liver - drug effects Liver Neoplasms - pathology Male Medical sciences Myocardial Contraction - drug effects Organ Specificity Oxygen Consumption - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, LDL - metabolism Safety Thyroid Hormones - pharmacology Thyromimetic Triglycerides - blood Triiodothyronine - metabolism Tumor Cells, Cultured
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