Low-density lipoproteins increase intracellular calcium in aequorin-loaded platelets
Low-density lipoproteins activate isolated human platelets. The mechanism of this activation is unknown, but may involve increased phosphoinositide turnover. We have examined the effect of low-density lipoproteins on intracellular calcium concentrations in platelets loaded with the photoprotein aequ...
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| Veröffentlicht in: | FEBS letters 1988-10, Vol.238 (2), p.357-360 |
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| creator | Dunn, R.C. Schachter, M. Miles, C.M.M. Feher, M.D. Tranter, P.R. Bruckdorfer, K.R. Sever, P.S. |
| description | Low-density lipoproteins activate isolated human platelets. The mechanism of this activation is unknown, but may involve increased phosphoinositide turnover. We have examined the effect of low-density lipoproteins on intracellular calcium concentrations in platelets loaded with the photoprotein aequorin. The lipoproteins induced concentration-dependent increases in intracellular calcium, associated with shape change and aggregation. These responses could be partially inhibited by the removal of extracellular calcium and by pre-incubation with acetylsalicylic acid. They were also antagonised by agents which increase cellular concentrations of cyclic adenosine and guanosine monophosphates. It is not clear whether the platelet-lipoprotein interaction involves a ‘classical’ lipoprotein receptor. |
| doi_str_mv | 10.1016/0014-5793(88)80512-X |
| format | Article |
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The mechanism of this activation is unknown, but may involve increased phosphoinositide turnover. We have examined the effect of low-density lipoproteins on intracellular calcium concentrations in platelets loaded with the photoprotein aequorin. The lipoproteins induced concentration-dependent increases in intracellular calcium, associated with shape change and aggregation. These responses could be partially inhibited by the removal of extracellular calcium and by pre-incubation with acetylsalicylic acid. They were also antagonised by agents which increase cellular concentrations of cyclic adenosine and guanosine monophosphates. It is not clear whether the platelet-lipoprotein interaction involves a ‘classical’ lipoprotein receptor.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(88)80512-X</identifier><identifier>PMID: 2844604</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Aequorin ; Aspirin - pharmacology ; Biological and medical sciences ; Blood coagulation. Blood cells ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Calcium - blood ; Cyclic GMP - analogs & derivatives ; Cyclic GMP - pharmacology ; Fundamental and applied biological sciences. Psychology ; HDL high-density lipoprotein ; Human platelet ; Humans ; intracellular Ca 2 ; intracellular Ca2 ; intracellular calcium concentration ; Isoquinolines - pharmacology ; LDL ; LDL low-density lipoprotein ; Lipoproteins, LDL - pharmacology ; Luminescence ; Luminescent Proteins ; Molecular and cellular biology ; Platelet ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors ; Tetrahydroisoquinolines ; VLDL very low density lipoprotein</subject><ispartof>FEBS letters, 1988-10, Vol.238 (2), p.357-360</ispartof><rights>1988</rights><rights>FEBS Letters 238 (1988) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480X-881ce999fcdd9a7fe03a94b7d5057eafa8a4148a13f3c3ae6ead4a00a7bcc18c3</citedby><cites>FETCH-LOGICAL-c480X-881ce999fcdd9a7fe03a94b7d5057eafa8a4148a13f3c3ae6ead4a00a7bcc18c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(88)80512-X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6635880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2844604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dunn, R.C.</creatorcontrib><creatorcontrib>Schachter, M.</creatorcontrib><creatorcontrib>Miles, C.M.M.</creatorcontrib><creatorcontrib>Feher, M.D.</creatorcontrib><creatorcontrib>Tranter, P.R.</creatorcontrib><creatorcontrib>Bruckdorfer, K.R.</creatorcontrib><creatorcontrib>Sever, P.S.</creatorcontrib><title>Low-density lipoproteins increase intracellular calcium in aequorin-loaded platelets</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Low-density lipoproteins activate isolated human platelets. The mechanism of this activation is unknown, but may involve increased phosphoinositide turnover. We have examined the effect of low-density lipoproteins on intracellular calcium concentrations in platelets loaded with the photoprotein aequorin. The lipoproteins induced concentration-dependent increases in intracellular calcium, associated with shape change and aggregation. These responses could be partially inhibited by the removal of extracellular calcium and by pre-incubation with acetylsalicylic acid. They were also antagonised by agents which increase cellular concentrations of cyclic adenosine and guanosine monophosphates. It is not clear whether the platelet-lipoprotein interaction involves a ‘classical’ lipoprotein receptor.</description><subject>Aequorin</subject><subject>Aspirin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Calcium - blood</subject><subject>Cyclic GMP - analogs & derivatives</subject><subject>Cyclic GMP - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HDL high-density lipoprotein</subject><subject>Human platelet</subject><subject>Humans</subject><subject>intracellular Ca 2</subject><subject>intracellular Ca2</subject><subject>intracellular calcium concentration</subject><subject>Isoquinolines - pharmacology</subject><subject>LDL</subject><subject>LDL low-density lipoprotein</subject><subject>Lipoproteins, LDL - pharmacology</subject><subject>Luminescence</subject><subject>Luminescent Proteins</subject><subject>Molecular and cellular biology</subject><subject>Platelet</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors</subject><subject>Tetrahydroisoquinolines</subject><subject>VLDL very low density lipoprotein</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFqGzEQQEVpSZ2kf9DCHkpJDttIlrQ7ewmkIW4Lhl5S8E2MpVlQkXcdaTfBfx9tbHxMc5I082Y08xj7LPh3wUV1xblQpa4beQFwCVyLebl6x2YCallKVcF7NjsiH9lpSv94foNoTtjJHJSquJqx-2X_VDrqkh92RfDbfhv7gXyXCt_ZSJgoX4aIlkIYA8bCYrB-3ORogfQw9tF3ZejRkSu2AQcKNKRz9qHFkOjT4Txjfxd397e_yuWfn79vb5alVcBXJYCw1DRNa51rsG6JS2zUunaa65qwRUAlFKCQrbQSqSJ0CjnHem2tACvP2Ld93zz0w0hpMBufpkmxo35Mpgalp4X_Cwqtay2VzKDagzb2KUVqzTb6DcadEdxM1s2k1ExKDYB5sW5WuezLof-43pA7Fh005_zXQx5TFthG7KxPR6yqpAbgGVvssScfaPemr83i7sd8SkxxgJfoNM_1vhFl-4-eoknWU2fJ-Uh2MK73ry_0DGAUs80</recordid><startdate>19881010</startdate><enddate>19881010</enddate><creator>Dunn, R.C.</creator><creator>Schachter, M.</creator><creator>Miles, C.M.M.</creator><creator>Feher, M.D.</creator><creator>Tranter, P.R.</creator><creator>Bruckdorfer, K.R.</creator><creator>Sever, P.S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19881010</creationdate><title>Low-density lipoproteins increase intracellular calcium in aequorin-loaded platelets</title><author>Dunn, R.C. ; Schachter, M. ; Miles, C.M.M. ; Feher, M.D. ; Tranter, P.R. ; Bruckdorfer, K.R. ; Sever, P.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480X-881ce999fcdd9a7fe03a94b7d5057eafa8a4148a13f3c3ae6ead4a00a7bcc18c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aequorin</topic><topic>Aspirin - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Calcium - blood</topic><topic>Cyclic GMP - analogs & derivatives</topic><topic>Cyclic GMP - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HDL high-density lipoprotein</topic><topic>Human platelet</topic><topic>Humans</topic><topic>intracellular Ca 2</topic><topic>intracellular Ca2</topic><topic>intracellular calcium concentration</topic><topic>Isoquinolines - pharmacology</topic><topic>LDL</topic><topic>LDL low-density lipoprotein</topic><topic>Lipoproteins, LDL - pharmacology</topic><topic>Luminescence</topic><topic>Luminescent Proteins</topic><topic>Molecular and cellular biology</topic><topic>Platelet</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors</topic><topic>Tetrahydroisoquinolines</topic><topic>VLDL very low density lipoprotein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dunn, R.C.</creatorcontrib><creatorcontrib>Schachter, M.</creatorcontrib><creatorcontrib>Miles, C.M.M.</creatorcontrib><creatorcontrib>Feher, M.D.</creatorcontrib><creatorcontrib>Tranter, P.R.</creatorcontrib><creatorcontrib>Bruckdorfer, K.R.</creatorcontrib><creatorcontrib>Sever, P.S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dunn, R.C.</au><au>Schachter, M.</au><au>Miles, C.M.M.</au><au>Feher, M.D.</au><au>Tranter, P.R.</au><au>Bruckdorfer, K.R.</au><au>Sever, P.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-density lipoproteins increase intracellular calcium in aequorin-loaded platelets</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1988-10-10</date><risdate>1988</risdate><volume>238</volume><issue>2</issue><spage>357</spage><epage>360</epage><pages>357-360</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Low-density lipoproteins activate isolated human platelets. The mechanism of this activation is unknown, but may involve increased phosphoinositide turnover. We have examined the effect of low-density lipoproteins on intracellular calcium concentrations in platelets loaded with the photoprotein aequorin. The lipoproteins induced concentration-dependent increases in intracellular calcium, associated with shape change and aggregation. These responses could be partially inhibited by the removal of extracellular calcium and by pre-incubation with acetylsalicylic acid. They were also antagonised by agents which increase cellular concentrations of cyclic adenosine and guanosine monophosphates. It is not clear whether the platelet-lipoprotein interaction involves a ‘classical’ lipoprotein receptor.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2844604</pmid><doi>10.1016/0014-5793(88)80512-X</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Aequorin Aspirin - pharmacology Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Calcium - blood Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Fundamental and applied biological sciences. Psychology HDL high-density lipoprotein Human platelet Humans intracellular Ca 2 intracellular Ca2 intracellular calcium concentration Isoquinolines - pharmacology LDL LDL low-density lipoprotein Lipoproteins, LDL - pharmacology Luminescence Luminescent Proteins Molecular and cellular biology Platelet Platelet Aggregation - drug effects Platelet Aggregation Inhibitors Tetrahydroisoquinolines VLDL very low density lipoprotein |
| title | Low-density lipoproteins increase intracellular calcium in aequorin-loaded platelets |
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