Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice
Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-11, Vol.274 (5288), p.795-798 |
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| creator | Lindberg, Frederik P. Bullard, Daniel C. Caver, Tony E. Gresham, Hattie D. Beaudet, Arthur L. Brown, Eric J. |
| description | Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous littermates. In vivo, they had an early defect in PMN accumulation at the site of infection. In vitro, IAP$^{-/-}$ PMNs were deficient in $\beta_3$ integrin-dependent ligand binding, activation of an oxidative burst, and Fc receptor-mediated phagocytosis. Thus, IAP plays a key role in host defense by participating both in PMN migration in response to bacterial infection and in PMN activation at extravascular sites. |
| doi_str_mv | 10.1126/science.274.5288.795 |
| format | Article |
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Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous littermates. In vivo, they had an early defect in PMN accumulation at the site of infection. In vitro, IAP$^{-/-}$ PMNs were deficient in $\beta_3$ integrin-dependent ligand binding, activation of an oxidative burst, and Fc receptor-mediated phagocytosis. Thus, IAP plays a key role in host defense by participating both in PMN migration in response to bacterial infection and in PMN activation at extravascular sites.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.274.5288.795</identifier><identifier>PMID: 8864123</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Amino Acid Sequence ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antigens, CD - genetics ; Antigens, CD - immunology ; Antigens, CD - physiology ; Bacteria ; Biological and medical sciences ; Carrier Proteins - genetics ; Carrier Proteins - immunology ; CD47 Antigen ; Cell Movement ; Erythrocytes ; Escherichia coli ; Escherichia coli Infections - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Targeting ; Genetics ; Genotypes ; Heterozygote ; Heterozygotes ; Human migration ; Immunity, Innate ; Immunobiology ; Infections ; Integrin beta3 ; Integrins ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Migration ; Molecular Sequence Data ; Natural immunity ; Neutrophil Activation ; Neutrophils ; Neutrophils - immunology ; Neutrophils - physiology ; Organs and cells involved in the immune response ; Peptide Fragments - pharmacology ; Peritonitis - immunology ; Phagocytosis ; Phenotype ; Physiological aspects ; Platelet Membrane Glycoproteins - physiology ; Proteins ; Respiratory Burst ; Rodents</subject><ispartof>Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5288), p.795-798</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1997 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 1, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c782t-4d112791b266a6cd50d92d46b685e8dc4bc5bd0cc5e96436cddf9ca1b01fff1d3</citedby><cites>FETCH-LOGICAL-c782t-4d112791b266a6cd50d92d46b685e8dc4bc5bd0cc5e96436cddf9ca1b01fff1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2891760$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2891760$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2479205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8864123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindberg, Frederik P.</creatorcontrib><creatorcontrib>Bullard, Daniel C.</creatorcontrib><creatorcontrib>Caver, Tony E.</creatorcontrib><creatorcontrib>Gresham, Hattie D.</creatorcontrib><creatorcontrib>Beaudet, Arthur L.</creatorcontrib><creatorcontrib>Brown, Eric J.</creatorcontrib><title>Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous littermates. In vivo, they had an early defect in PMN accumulation at the site of infection. In vitro, IAP$^{-/-}$ PMNs were deficient in $\beta_3$ integrin-dependent ligand binding, activation of an oxidative burst, and Fc receptor-mediated phagocytosis. Thus, IAP plays a key role in host defense by participating both in PMN migration in response to bacterial infection and in PMN activation at extravascular sites.</description><subject>Amino Acid Sequence</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - physiology</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - immunology</subject><subject>CD47 Antigen</subject><subject>Cell Movement</subject><subject>Erythrocytes</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Targeting</topic><topic>Genetics</topic><topic>Genotypes</topic><topic>Heterozygote</topic><topic>Heterozygotes</topic><topic>Human migration</topic><topic>Immunity, Innate</topic><topic>Immunobiology</topic><topic>Infections</topic><topic>Integrin beta3</topic><topic>Integrins</topic><topic>Ligands</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Migration</topic><topic>Molecular Sequence Data</topic><topic>Natural immunity</topic><topic>Neutrophil Activation</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - physiology</topic><topic>Organs and cells involved in the immune response</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peritonitis - immunology</topic><topic>Phagocytosis</topic><topic>Phenotype</topic><topic>Physiological aspects</topic><topic>Platelet Membrane Glycoproteins - 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Science)</jtitle><addtitle>Science</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>274</volume><issue>5288</issue><spage>795</spage><epage>798</epage><pages>795-798</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous littermates. In vivo, they had an early defect in PMN accumulation at the site of infection. In vitro, IAP$^{-/-}$ PMNs were deficient in $\beta_3$ integrin-dependent ligand binding, activation of an oxidative burst, and Fc receptor-mediated phagocytosis. Thus, IAP plays a key role in host defense by participating both in PMN migration in response to bacterial infection and in PMN activation at extravascular sites.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8864123</pmid><doi>10.1126/science.274.5288.795</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5288), p.795-798 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78451608 |
| source | MEDLINE; Jstor Complete Legacy; Science Online_科学在线 |
| subjects | Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - physiology Bacteria Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - immunology CD47 Antigen Cell Movement Erythrocytes Escherichia coli Escherichia coli Infections - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Targeting Genetics Genotypes Heterozygote Heterozygotes Human migration Immunity, Innate Immunobiology Infections Integrin beta3 Integrins Ligands Male Mice Mice, Inbred C57BL Mice, Knockout Migration Molecular Sequence Data Natural immunity Neutrophil Activation Neutrophils Neutrophils - immunology Neutrophils - physiology Organs and cells involved in the immune response Peptide Fragments - pharmacology Peritonitis - immunology Phagocytosis Phenotype Physiological aspects Platelet Membrane Glycoproteins - physiology Proteins Respiratory Burst Rodents |
| title | Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T18%3A33%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20Resistance%20to%20Bacterial%20Infection%20and%20Granulocyte%20Defects%20in%20IAP-Deficient%20Mice&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Lindberg,%20Frederik%20P.&rft.date=1996-11-01&rft.volume=274&rft.issue=5288&rft.spage=795&rft.epage=798&rft.pages=795-798&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.274.5288.795&rft_dat=%3Cgale_proqu%3EA18875000%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213562549&rft_id=info:pmid/8864123&rft_galeid=A18875000&rft_jstor_id=2891760&rfr_iscdi=true |