Haemophilus influenzae Type b Anticapsular Antibody Responses to PRP-Pertussis and PRP-D Vaccines in Alaska Native Infants
To evaluate immune responses in Alaska Native infants at high risk for invasive Haemophilus influenzae type b (Hib) disease, we studied PRP-pertussis and PRP-D conjugate vaccines in this population relative to responses in white infants in California and New York. Infants were immunized at two, four...
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| Veröffentlicht in: | The Journal of infectious diseases 1988-10, Vol.158 (4), p.719-723 |
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| container_title | The Journal of infectious diseases |
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| creator | Ward, Joel I. Brenneman, George Lepow, Martha Lum, Milton Burkhart, Kelly Chiu, Chung Y. |
| description | To evaluate immune responses in Alaska Native infants at high risk for invasive Haemophilus influenzae type b (Hib) disease, we studied PRP-pertussis and PRP-D conjugate vaccines in this population relative to responses in white infants in California and New York. Infants were immunized at two, four, and six months of age (both vaccines). In the PRP-pertussis trial, there were no significant differences in antibody levels at any age between Alaska Native infants and infants from California. Only 50% of the infants had a two fold or greater antibody rise after three doses. In the PRP-D trial, antibody levels at two months of age (presumably maternally acquired) were significantly higher for Alaska Native infants compared with infants from New York (P = .002). There were no significant differences in antibody levels after any of the three doses. Among Alaska Native infants there was no significant difference in antibody response based upon degree of ethnic purity. |
| doi_str_mv | 10.1093/infdis/158.4.719 |
| format | Article |
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Infants were immunized at two, four, and six months of age (both vaccines). In the PRP-pertussis trial, there were no significant differences in antibody levels at any age between Alaska Native infants and infants from California. Only 50% of the infants had a two fold or greater antibody rise after three doses. In the PRP-D trial, antibody levels at two months of age (presumably maternally acquired) were significantly higher for Alaska Native infants compared with infants from New York (P = .002). There were no significant differences in antibody levels after any of the three doses. Among Alaska Native infants there was no significant difference in antibody response based upon degree of ethnic purity.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/158.4.719</identifier><identifier>PMID: 3262694</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Alaska ; Alaska Natives ; Antibodies ; Antibodies, Bacterial - biosynthesis ; Asian Continental Ancestry Group ; Bacterial Vaccines - immunology ; Biological and medical sciences ; California ; Conjugate vaccines ; Diphtheria Toxoid - immunology ; Disease risk ; Dosage ; Haemophilus influenzae ; Haemophilus influenzae - immunology ; Haemophilus influenzae type b ; Haemophilus Vaccines ; Humans ; Immune response ; Immunization, Secondary ; Immunopathology ; Immunotherapy (general aspects) ; Infant ; Major Articles ; Medical genetics ; Medical sciences ; New York ; Pertussis Vaccine - immunology ; Polysaccharides ; Vaccination</subject><ispartof>The Journal of infectious diseases, 1988-10, Vol.158 (4), p.719-723</ispartof><rights>Copyright 1988 The University of Chicago</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-5cb3a7ce997d126f9cdd04b7bce381e0acbcf19e5f51b511f83cc9a9616a22ca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30136374$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30136374$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6994860$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3262694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ward, Joel I.</creatorcontrib><creatorcontrib>Brenneman, George</creatorcontrib><creatorcontrib>Lepow, Martha</creatorcontrib><creatorcontrib>Lum, Milton</creatorcontrib><creatorcontrib>Burkhart, Kelly</creatorcontrib><creatorcontrib>Chiu, Chung Y.</creatorcontrib><title>Haemophilus influenzae Type b Anticapsular Antibody Responses to PRP-Pertussis and PRP-D Vaccines in Alaska Native Infants</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To evaluate immune responses in Alaska Native infants at high risk for invasive Haemophilus influenzae type b (Hib) disease, we studied PRP-pertussis and PRP-D conjugate vaccines in this population relative to responses in white infants in California and New York. Infants were immunized at two, four, and six months of age (both vaccines). In the PRP-pertussis trial, there were no significant differences in antibody levels at any age between Alaska Native infants and infants from California. Only 50% of the infants had a two fold or greater antibody rise after three doses. In the PRP-D trial, antibody levels at two months of age (presumably maternally acquired) were significantly higher for Alaska Native infants compared with infants from New York (P = .002). There were no significant differences in antibody levels after any of the three doses. Among Alaska Native infants there was no significant difference in antibody response based upon degree of ethnic purity.</description><subject>Alaska</subject><subject>Alaska Natives</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Asian Continental Ancestry Group</subject><subject>Bacterial Vaccines - immunology</subject><subject>Biological and medical sciences</subject><subject>California</subject><subject>Conjugate vaccines</subject><subject>Diphtheria Toxoid - immunology</subject><subject>Disease risk</subject><subject>Dosage</subject><subject>Haemophilus influenzae</subject><subject>Haemophilus influenzae - immunology</subject><subject>Haemophilus influenzae type b</subject><subject>Haemophilus Vaccines</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunization, Secondary</subject><subject>Immunopathology</subject><subject>Immunotherapy (general aspects)</subject><subject>Infant</subject><subject>Major Articles</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>New York</subject><subject>Pertussis Vaccine - immunology</subject><subject>Polysaccharides</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9v0zAYhi0EGmVw54LkA-KWzo5jOz5240cnVdBNA6FdrC-OI7ylTuYvQXR_PelatiMn6_Pzvs_lJeQtZ3POjDgJsakDnnBZzou55uYZmXEpdKYUF8_JjLE8z3hpzEvyCvGGMVYIpY_IkchVrkwxI_dL8Juu_xXaEelka0cf78HTq23vaUUXcQgOehxbSA9H1dVbeumx7yJ6pENH15frbO3TMCIGpBDrh5-P9Ac4F6LfWemiBbwF-hWG8NvT89hAHPA1edFAi_7N4T0m3z9_ujpbZqtvX87PFqvMidwMmXSVAO28MbrmuWqMq2tWVLpyXpTcM3CVa7jxspG8kpw3pXDOgFFcQZ47EMfkw97bp-5u9DjYTUDn2xai70a0uiwkKzX7b5BLVjApxRRk-6BLHWLyje1T2EDaWs7sbhe732VqlLaw0y5T5d3BPVYbXz8WDkNM_P2BAzpomwTRTYJ_MWVMUSr2pLnBoUtPFsaFEnqnyfY84OD_PHJIt1ZpoaVd_ry2F6d8dcGvT-2p-AuOtrFj</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>Ward, Joel I.</creator><creator>Brenneman, George</creator><creator>Lepow, Martha</creator><creator>Lum, Milton</creator><creator>Burkhart, Kelly</creator><creator>Chiu, Chung Y.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198810</creationdate><title>Haemophilus influenzae Type b Anticapsular Antibody Responses to PRP-Pertussis and PRP-D Vaccines in Alaska Native Infants</title><author>Ward, Joel I. ; Brenneman, George ; Lepow, Martha ; Lum, Milton ; Burkhart, Kelly ; Chiu, Chung Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-5cb3a7ce997d126f9cdd04b7bce381e0acbcf19e5f51b511f83cc9a9616a22ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alaska</topic><topic>Alaska Natives</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Asian Continental Ancestry Group</topic><topic>Bacterial Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>California</topic><topic>Conjugate vaccines</topic><topic>Diphtheria Toxoid - immunology</topic><topic>Disease risk</topic><topic>Dosage</topic><topic>Haemophilus influenzae</topic><topic>Haemophilus influenzae - immunology</topic><topic>Haemophilus influenzae type b</topic><topic>Haemophilus Vaccines</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunization, Secondary</topic><topic>Immunopathology</topic><topic>Immunotherapy (general aspects)</topic><topic>Infant</topic><topic>Major Articles</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>New York</topic><topic>Pertussis Vaccine - immunology</topic><topic>Polysaccharides</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ward, Joel I.</creatorcontrib><creatorcontrib>Brenneman, George</creatorcontrib><creatorcontrib>Lepow, Martha</creatorcontrib><creatorcontrib>Lum, Milton</creatorcontrib><creatorcontrib>Burkhart, Kelly</creatorcontrib><creatorcontrib>Chiu, Chung Y.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ward, Joel I.</au><au>Brenneman, George</au><au>Lepow, Martha</au><au>Lum, Milton</au><au>Burkhart, Kelly</au><au>Chiu, Chung Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemophilus influenzae Type b Anticapsular Antibody Responses to PRP-Pertussis and PRP-D Vaccines in Alaska Native Infants</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1988-10</date><risdate>1988</risdate><volume>158</volume><issue>4</issue><spage>719</spage><epage>723</epage><pages>719-723</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To evaluate immune responses in Alaska Native infants at high risk for invasive Haemophilus influenzae type b (Hib) disease, we studied PRP-pertussis and PRP-D conjugate vaccines in this population relative to responses in white infants in California and New York. Infants were immunized at two, four, and six months of age (both vaccines). In the PRP-pertussis trial, there were no significant differences in antibody levels at any age between Alaska Native infants and infants from California. Only 50% of the infants had a two fold or greater antibody rise after three doses. In the PRP-D trial, antibody levels at two months of age (presumably maternally acquired) were significantly higher for Alaska Native infants compared with infants from New York (P = .002). There were no significant differences in antibody levels after any of the three doses. Among Alaska Native infants there was no significant difference in antibody response based upon degree of ethnic purity.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3262694</pmid><doi>10.1093/infdis/158.4.719</doi><tpages>5</tpages></addata></record> |
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| subjects | Alaska Alaska Natives Antibodies Antibodies, Bacterial - biosynthesis Asian Continental Ancestry Group Bacterial Vaccines - immunology Biological and medical sciences California Conjugate vaccines Diphtheria Toxoid - immunology Disease risk Dosage Haemophilus influenzae Haemophilus influenzae - immunology Haemophilus influenzae type b Haemophilus Vaccines Humans Immune response Immunization, Secondary Immunopathology Immunotherapy (general aspects) Infant Major Articles Medical genetics Medical sciences New York Pertussis Vaccine - immunology Polysaccharides Vaccination |
| title | Haemophilus influenzae Type b Anticapsular Antibody Responses to PRP-Pertussis and PRP-D Vaccines in Alaska Native Infants |
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