Kinetics of peritoneal dialysis in children: Role of lymphatics
Kinetics of peritoneal dialysis in children: Role of lymphatics. Intraperitoneal fluid is absorbed continuously by convective flow into the peritoneal cavity lymphatics. We evaluated the role of lymphatic absorption in the kinetics of peritoneal dialysis during standardized four hour exchanges in si...
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| Veröffentlicht in: | Kidney international 1988-07, Vol.34 (1), p.82-88 |
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| creator | Mactier, Robert A. Khanna, Ramesh Moore, Harold Russ, Julie Nolph, Karl D. Groshong, Ted |
| description | Kinetics of peritoneal dialysis in children: Role of lymphatics. Intraperitoneal fluid is absorbed continuously by convective flow into the peritoneal cavity lymphatics. We evaluated the role of lymphatic absorption in the kinetics of peritoneal dialysis during standardized four hour exchanges in six children using 40 ml/kg of 2.5% dextrose dialysis solution. Cumulative lymphatic absorption averaged 10.4 ± 1.6 ml/kg and reduced the total net transcapillary ultrafiltration during the dwell time by 73 ± 10%. Due to the considerable lymphatic absorption rate, maximum intraperitoneal volume was observed before osmolar equilibrium. Extrapolated to four study exchanges per day, lymphatic absorption decreased the potential daily drain volumes in the children by 27 ± 5% and daily peritoneal urea and creatinine clearances by 24 ± 4% and 22 ± 5%, respectively. Compared with four hour exchanges using two liters of 2.5% dextrose dialysis solution in 10 adult CAPD patients with average peritoneal transport, the children had more rapid equilibration of urea, greater absorption of dialysate glucose, higher lymphatic absorption and lower net ultrafiltration (P < 0.01 to P < 0.05). Lymphatic absorption therefore causes a relatively greater reduction in net ultrafiltration and solute clearances in children than in adults. |
| doi_str_mv | 10.1038/ki.1988.148 |
| format | Article |
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Intraperitoneal fluid is absorbed continuously by convective flow into the peritoneal cavity lymphatics. We evaluated the role of lymphatic absorption in the kinetics of peritoneal dialysis during standardized four hour exchanges in six children using 40 ml/kg of 2.5% dextrose dialysis solution. Cumulative lymphatic absorption averaged 10.4 ± 1.6 ml/kg and reduced the total net transcapillary ultrafiltration during the dwell time by 73 ± 10%. Due to the considerable lymphatic absorption rate, maximum intraperitoneal volume was observed before osmolar equilibrium. Extrapolated to four study exchanges per day, lymphatic absorption decreased the potential daily drain volumes in the children by 27 ± 5% and daily peritoneal urea and creatinine clearances by 24 ± 4% and 22 ± 5%, respectively. Compared with four hour exchanges using two liters of 2.5% dextrose dialysis solution in 10 adult CAPD patients with average peritoneal transport, the children had more rapid equilibration of urea, greater absorption of dialysate glucose, higher lymphatic absorption and lower net ultrafiltration (P < 0.01 to P < 0.05). Lymphatic absorption therefore causes a relatively greater reduction in net ultrafiltration and solute clearances in children than in adults.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1988.148</identifier><identifier>PMID: 3172639</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Emergency and intensive care: neonates and children. Prematurity. 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Intraperitoneal fluid is absorbed continuously by convective flow into the peritoneal cavity lymphatics. We evaluated the role of lymphatic absorption in the kinetics of peritoneal dialysis during standardized four hour exchanges in six children using 40 ml/kg of 2.5% dextrose dialysis solution. Cumulative lymphatic absorption averaged 10.4 ± 1.6 ml/kg and reduced the total net transcapillary ultrafiltration during the dwell time by 73 ± 10%. Due to the considerable lymphatic absorption rate, maximum intraperitoneal volume was observed before osmolar equilibrium. Extrapolated to four study exchanges per day, lymphatic absorption decreased the potential daily drain volumes in the children by 27 ± 5% and daily peritoneal urea and creatinine clearances by 24 ± 4% and 22 ± 5%, respectively. Compared with four hour exchanges using two liters of 2.5% dextrose dialysis solution in 10 adult CAPD patients with average peritoneal transport, the children had more rapid equilibration of urea, greater absorption of dialysate glucose, higher lymphatic absorption and lower net ultrafiltration (P < 0.01 to P < 0.05). Lymphatic absorption therefore causes a relatively greater reduction in net ultrafiltration and solute clearances in children than in adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kinetics</subject><subject>Lymphatic System - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peritoneal Dialysis, Continuous Ambulatory</subject><subject>Ultrafiltration</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1r3DAQhkVoSTYfp5xDfCi5BG_0acu9lLIkaWigUJqz0MojMlmtvZW8gf33kfGyp5yEeJ-ZeXkIuWR0zqjQdyucs0brOZP6iMyY4qJktVJfyIxSrUquhD4hpym90fxvBD0mx4LVvBLNjPz4jR0M6FLR-2IDEYe-AxuKFm3YJUwFdoV7xdBG6L4Xf_sAIxh2682rHcfOyVdvQ4KL_XtGXh7u_y1-lc9_Hp8WP59LJzkdymVTCa04VVUlG_BVyxlVubT3Wuau1qqGSkld1daiqSRrK6-VdYIttaTecXFGbqa9m9j_30IazBqTgxBsB_02mVpLRTmnGbydQBf7lCJ4s4m4tnFnGDWjLrNCM-oyWVemr_Zrt8s1tAd27yfn3_a5Tc4GH23nMB2wuuYy987Y9YR1dthGOOQrHC9Nh9REQJb0jhBNcgidgxYjuMG0PX5a8ANfWIyx</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Mactier, Robert A.</creator><creator>Khanna, Ramesh</creator><creator>Moore, Harold</creator><creator>Russ, Julie</creator><creator>Nolph, Karl D.</creator><creator>Groshong, Ted</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Kinetics of peritoneal dialysis in children: Role of lymphatics</title><author>Mactier, Robert A. ; Khanna, Ramesh ; Moore, Harold ; Russ, Julie ; Nolph, Karl D. ; Groshong, Ted</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-b963852056649ef6d2105198ff84175aa590440c6d739641d6f85ac31b840fc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Kinetics</topic><topic>Lymphatic System - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peritoneal Dialysis, Continuous Ambulatory</topic><topic>Ultrafiltration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mactier, Robert A.</creatorcontrib><creatorcontrib>Khanna, Ramesh</creatorcontrib><creatorcontrib>Moore, Harold</creatorcontrib><creatorcontrib>Russ, Julie</creatorcontrib><creatorcontrib>Nolph, Karl D.</creatorcontrib><creatorcontrib>Groshong, Ted</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mactier, Robert A.</au><au>Khanna, Ramesh</au><au>Moore, Harold</au><au>Russ, Julie</au><au>Nolph, Karl D.</au><au>Groshong, Ted</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of peritoneal dialysis in children: Role of lymphatics</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>34</volume><issue>1</issue><spage>82</spage><epage>88</epage><pages>82-88</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Kinetics of peritoneal dialysis in children: Role of lymphatics. Intraperitoneal fluid is absorbed continuously by convective flow into the peritoneal cavity lymphatics. We evaluated the role of lymphatic absorption in the kinetics of peritoneal dialysis during standardized four hour exchanges in six children using 40 ml/kg of 2.5% dextrose dialysis solution. Cumulative lymphatic absorption averaged 10.4 ± 1.6 ml/kg and reduced the total net transcapillary ultrafiltration during the dwell time by 73 ± 10%. Due to the considerable lymphatic absorption rate, maximum intraperitoneal volume was observed before osmolar equilibrium. Extrapolated to four study exchanges per day, lymphatic absorption decreased the potential daily drain volumes in the children by 27 ± 5% and daily peritoneal urea and creatinine clearances by 24 ± 4% and 22 ± 5%, respectively. Compared with four hour exchanges using two liters of 2.5% dextrose dialysis solution in 10 adult CAPD patients with average peritoneal transport, the children had more rapid equilibration of urea, greater absorption of dialysate glucose, higher lymphatic absorption and lower net ultrafiltration (P < 0.01 to P < 0.05). Lymphatic absorption therefore causes a relatively greater reduction in net ultrafiltration and solute clearances in children than in adults.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3172639</pmid><doi>10.1038/ki.1988.148</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Child Child, Preschool Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Humans Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Kinetics Lymphatic System - physiology Male Medical sciences Peritoneal Dialysis, Continuous Ambulatory Ultrafiltration |
| title | Kinetics of peritoneal dialysis in children: Role of lymphatics |
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