Quantitative Analysis of von Willebrand Factor Propeptide Release In Vivo: Effect of Experimental Endotoxemia and Administration of 1-Deamino-8-D-Arginine Vasopressin in Humans

The results of studies with cultured endothelial cells have shown that most von Willebrand factor (vWF) synthesized is directly secreted (constitutive pathway) and consists of both mature vWF, its precursor molecule pro-vWF, and the cleaved vWF prosequence. Only fully processed, functionally mature...

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Veröffentlicht in:	Blood 1996-10, Vol.88 (8), p.2951-2958
Hauptverfasser:	Borchiellini, Alessandra, Fijnvandraat, Karin, ten Cate, Jan Wouter, Pajkrt, Dasja, van Deventer, Sander J.H., Pasterkamp, Gerard, Meijer-Huizinga, Fenny, Zwart-Huinink, Lineke, Voorberg, Jan, van Mourik, Jan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biological and medical sciences Cardiovascular system Deamino Arginine Vasopressin - pharmacology Endothelium, Vascular - metabolism Endotoxemia - blood Endotoxins - pharmacology Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mice Mice, Inbred BALB C Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Precursors - analysis Protein Precursors - metabolism Protein Processing, Post-Translational Secretory Rate - drug effects von Willebrand Factor - analysis von Willebrand Factor - biosynthesis von Willebrand Factor - metabolism
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