Ultraviolet Radiation Alters Choline Phospholipid Metabolism in Human Keratinocytes
Ultraviolet radiation B (UVB–290–320 nm) induces inflammation and hyperproliferation in human epidermis. This response is associated with the recovery from irradiated skin of inflammatory mediators derived from membrane phospholipids. We have previously reported that UVB stimulates the production of...
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| Veröffentlicht in: | J. Invest. Dermatol.; (United States) 1988-10, Vol.91 (4), p.303-308 |
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| creator | DeLeo, Vincent Scheide, Sara Meshulam, Joel Hanson, Debra Cardullo, Alice |
| description | Ultraviolet radiation B (UVB–290–320 nm) induces inflammation and hyperproliferation in human epidermis. This response is associated with the recovery from irradiated skin of inflammatory mediators derived from membrane phospholipids. We have previously reported that UVB stimulates the production of such mediators by human keratinocytes (HK) in culture. In these studies we examined the effect of UVB on the metabolism of choline containing phospholipids in HK prelabeled with [3H] choline. UVB (400–1600J/m2) stimulated a dose dependent release of [3H] choline from HK within minutes of irradiation. Examination of media extracts by paper chromatography revealed that the released [3H] choline was predominately in the form of glycerophosphorylcholine. Examination of label remaining in membranes of cells after irradiation by acid precipitation and HPLC revealed that the origin of the released [3H] choline was the membrane phosphatidylcholine/lysophosphatidylcholine. These data support a concept of UVB stimulation of both a phospholipase A (1 or 2) and a lysophospholipase. These UVB induced alterations of HK membrane phospholipid metabolism likely have profound effects on UVB-induced inflammation and control of cell growth in human skin. |
| doi_str_mv | 10.1111/1523-1747.ep12475636 |
| format | Article |
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This response is associated with the recovery from irradiated skin of inflammatory mediators derived from membrane phospholipids. We have previously reported that UVB stimulates the production of such mediators by human keratinocytes (HK) in culture. In these studies we examined the effect of UVB on the metabolism of choline containing phospholipids in HK prelabeled with [3H] choline. UVB (400–1600J/m2) stimulated a dose dependent release of [3H] choline from HK within minutes of irradiation. Examination of media extracts by paper chromatography revealed that the released [3H] choline was predominately in the form of glycerophosphorylcholine. Examination of label remaining in membranes of cells after irradiation by acid precipitation and HPLC revealed that the origin of the released [3H] choline was the membrane phosphatidylcholine/lysophosphatidylcholine. These data support a concept of UVB stimulation of both a phospholipase A (1 or 2) and a lysophospholipase. These UVB induced alterations of HK membrane phospholipid metabolism likely have profound effects on UVB-induced inflammation and control of cell growth in human skin.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12475636</identifier><identifier>PMID: 2459259</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>550201 - Biochemistry- Tracer Techniques ; 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture ; ALCOHOLS ; AMINES ; AMMONIUM COMPOUNDS ; ANIMAL CELLS ; ANIMAL TISSUES ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; CARBOXYLESTERASES ; CELL CONSTITUENTS ; CELL MEMBRANES ; CELL PROLIFERATION ; Cells, Cultured ; CHOLINE ; CHROMATOGRAPHY ; Dermatology ; DOSE-RESPONSE RELATIONSHIPS ; DRUGS ; ELECTROMAGNETIC RADIATION ; ENZYMES ; Epidermal Cells ; EPIDERMIS ; Epidermis - metabolism ; Epidermis - radiation effects ; EPITHELIUM ; ESTERASES ; ESTERS ; Humans ; HYDROLASES ; HYDROXY COMPOUNDS ; Injuries of the skin. Diseases of the skin due to physical agents ; ISOTOPE APPLICATIONS ; KERATIN ; Keratins ; Kinetics ; LABELLED COMPOUNDS ; LIPASE ; LIPIDS ; LIPOTROPIC FACTORS ; LIQUID COLUMN CHROMATOGRAPHY ; MAMMALS ; MAN ; Medical sciences ; Membrane Lipids - metabolism ; MEMBRANE PROTEINS ; MEMBRANES ; METABOLISM ; ORGANIC COMPOUNDS ; ORGANIC PHOSPHORUS COMPOUNDS ; ORGANS ; Phosphatidylcholines - metabolism ; PHOSPHOLIPIDS ; PRIMATES ; PROTEINS ; QUATERNARY COMPOUNDS ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; SCLEROPROTEINS ; SEPARATION PROCESSES ; SKIN ; TISSUES ; TRACER TECHNIQUES ; Traumas. Diseases due to physical agents ; TRITIUM COMPOUNDS ; ULTRAVIOLET RADIATION ; Ultraviolet Rays - adverse effects ; VERTEBRATES</subject><ispartof>J. Invest. Dermatol.; (United States), 1988-10, Vol.91 (4), p.303-308</ispartof><rights>1988 The Society for Investigative Dermatology, Inc</rights><rights>1991 INIST-CNRS</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-dbdf45a0d77dad903137b6aee777978c1e49785dab46aa4f209ec9217a76a0843</citedby><cites>FETCH-LOGICAL-c443t-dbdf45a0d77dad903137b6aee777978c1e49785dab46aa4f209ec9217a76a0843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19550787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7065458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2459259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6557902$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>DeLeo, Vincent</creatorcontrib><creatorcontrib>Scheide, Sara</creatorcontrib><creatorcontrib>Meshulam, Joel</creatorcontrib><creatorcontrib>Hanson, Debra</creatorcontrib><creatorcontrib>Cardullo, Alice</creatorcontrib><creatorcontrib>Columbia Univ., NY (USA)</creatorcontrib><title>Ultraviolet Radiation Alters Choline Phospholipid Metabolism in Human Keratinocytes</title><title>J. Invest. Dermatol.; (United States)</title><addtitle>J Invest Dermatol</addtitle><description>Ultraviolet radiation B (UVB–290–320 nm) induces inflammation and hyperproliferation in human epidermis. This response is associated with the recovery from irradiated skin of inflammatory mediators derived from membrane phospholipids. We have previously reported that UVB stimulates the production of such mediators by human keratinocytes (HK) in culture. In these studies we examined the effect of UVB on the metabolism of choline containing phospholipids in HK prelabeled with [3H] choline. UVB (400–1600J/m2) stimulated a dose dependent release of [3H] choline from HK within minutes of irradiation. Examination of media extracts by paper chromatography revealed that the released [3H] choline was predominately in the form of glycerophosphorylcholine. Examination of label remaining in membranes of cells after irradiation by acid precipitation and HPLC revealed that the origin of the released [3H] choline was the membrane phosphatidylcholine/lysophosphatidylcholine. These data support a concept of UVB stimulation of both a phospholipase A (1 or 2) and a lysophospholipase. These UVB induced alterations of HK membrane phospholipid metabolism likely have profound effects on UVB-induced inflammation and control of cell growth in human skin.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture</subject><subject>ALCOHOLS</subject><subject>AMINES</subject><subject>AMMONIUM COMPOUNDS</subject><subject>ANIMAL CELLS</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>CARBOXYLESTERASES</subject><subject>CELL CONSTITUENTS</subject><subject>CELL MEMBRANES</subject><subject>CELL PROLIFERATION</subject><subject>Cells, Cultured</subject><subject>CHOLINE</subject><subject>CHROMATOGRAPHY</subject><subject>Dermatology</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>DRUGS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>ENZYMES</subject><subject>Epidermal Cells</subject><subject>EPIDERMIS</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - radiation effects</subject><subject>EPITHELIUM</subject><subject>ESTERASES</subject><subject>ESTERS</subject><subject>Humans</subject><subject>HYDROLASES</subject><subject>HYDROXY COMPOUNDS</subject><subject>Injuries of the skin. Diseases of the skin due to physical agents</subject><subject>ISOTOPE APPLICATIONS</subject><subject>KERATIN</subject><subject>Keratins</subject><subject>Kinetics</subject><subject>LABELLED COMPOUNDS</subject><subject>LIPASE</subject><subject>LIPIDS</subject><subject>LIPOTROPIC FACTORS</subject><subject>LIQUID COLUMN CHROMATOGRAPHY</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Medical sciences</subject><subject>Membrane Lipids - metabolism</subject><subject>MEMBRANE PROTEINS</subject><subject>MEMBRANES</subject><subject>METABOLISM</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC PHOSPHORUS COMPOUNDS</subject><subject>ORGANS</subject><subject>Phosphatidylcholines - metabolism</subject><subject>PHOSPHOLIPIDS</subject><subject>PRIMATES</subject><subject>PROTEINS</subject><subject>QUATERNARY COMPOUNDS</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>SCLEROPROTEINS</subject><subject>SEPARATION PROCESSES</subject><subject>SKIN</subject><subject>TISSUES</subject><subject>TRACER TECHNIQUES</subject><subject>Traumas. Diseases due to physical agents</subject><subject>TRITIUM COMPOUNDS</subject><subject>ULTRAVIOLET RADIATION</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>VERTEBRATES</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGL1DAQgIMo53r6DxSKqG89kzRp2hfhWNQTTxT1wLcwTaZspE16Sfbg_r0pu6xvl5cZMt8MmS-EvGT0gpXznkne1EwJdYEL40LJtmkfkc3p-jHZUMp5zSn_85Q8S-kvpawVsjsjZ1zInst-Q37dTDnCnQsT5uonWAfZBV9dThljqra7MDmP1Y9dSMuaL85W3zDDUPI0V85XV_sZfPUVY2n0wdxnTM_JkxGmhC-O8ZzcfPr4e3tVX3___GV7eV0bIZpc28GOQgK1SlmwPW1Yo4YWEJVSveoMQ1GCtDCIFkCMnPZoes4UqBZoJ5pz8vowN6TsdDIuo9mZ4D2arFspVU95gd4doCWG2z2mrGeXDE4TeAz7pFUnRNvIFRQH0MSQUsRRL9HNEO81o3oVrlezejWr_wsvba-O8_fDjPbUdDRc6m-OdUgGpjGCNy6dMEVbWb6kYG8fwlgvJVWdKtyHA4dF7J3DuO6N3qB1cV3bBvfwe_8BKxOpsg</recordid><startdate>19881001</startdate><enddate>19881001</enddate><creator>DeLeo, Vincent</creator><creator>Scheide, Sara</creator><creator>Meshulam, Joel</creator><creator>Hanson, Debra</creator><creator>Cardullo, Alice</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19881001</creationdate><title>Ultraviolet Radiation Alters Choline Phospholipid Metabolism in Human Keratinocytes</title><author>DeLeo, Vincent ; Scheide, Sara ; Meshulam, Joel ; Hanson, Debra ; Cardullo, Alice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-dbdf45a0d77dad903137b6aee777978c1e49785dab46aa4f209ec9217a76a0843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture</topic><topic>ALCOHOLS</topic><topic>AMINES</topic><topic>AMMONIUM COMPOUNDS</topic><topic>ANIMAL CELLS</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>CARBOXYLESTERASES</topic><topic>CELL CONSTITUENTS</topic><topic>CELL MEMBRANES</topic><topic>CELL PROLIFERATION</topic><topic>Cells, Cultured</topic><topic>CHOLINE</topic><topic>CHROMATOGRAPHY</topic><topic>Dermatology</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>DRUGS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>ENZYMES</topic><topic>Epidermal Cells</topic><topic>EPIDERMIS</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - radiation effects</topic><topic>EPITHELIUM</topic><topic>ESTERASES</topic><topic>ESTERS</topic><topic>Humans</topic><topic>HYDROLASES</topic><topic>HYDROXY COMPOUNDS</topic><topic>Injuries of the skin. Diseases of the skin due to physical agents</topic><topic>ISOTOPE APPLICATIONS</topic><topic>KERATIN</topic><topic>Keratins</topic><topic>Kinetics</topic><topic>LABELLED COMPOUNDS</topic><topic>LIPASE</topic><topic>LIPIDS</topic><topic>LIPOTROPIC FACTORS</topic><topic>LIQUID COLUMN CHROMATOGRAPHY</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Medical sciences</topic><topic>Membrane Lipids - metabolism</topic><topic>MEMBRANE PROTEINS</topic><topic>MEMBRANES</topic><topic>METABOLISM</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC PHOSPHORUS COMPOUNDS</topic><topic>ORGANS</topic><topic>Phosphatidylcholines - metabolism</topic><topic>PHOSPHOLIPIDS</topic><topic>PRIMATES</topic><topic>PROTEINS</topic><topic>QUATERNARY COMPOUNDS</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>SCLEROPROTEINS</topic><topic>SEPARATION PROCESSES</topic><topic>SKIN</topic><topic>TISSUES</topic><topic>TRACER TECHNIQUES</topic><topic>Traumas. Diseases due to physical agents</topic><topic>TRITIUM COMPOUNDS</topic><topic>ULTRAVIOLET RADIATION</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeLeo, Vincent</creatorcontrib><creatorcontrib>Scheide, Sara</creatorcontrib><creatorcontrib>Meshulam, Joel</creatorcontrib><creatorcontrib>Hanson, Debra</creatorcontrib><creatorcontrib>Cardullo, Alice</creatorcontrib><creatorcontrib>Columbia Univ., NY (USA)</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Invest. Dermatol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeLeo, Vincent</au><au>Scheide, Sara</au><au>Meshulam, Joel</au><au>Hanson, Debra</au><au>Cardullo, Alice</au><aucorp>Columbia Univ., NY (USA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultraviolet Radiation Alters Choline Phospholipid Metabolism in Human Keratinocytes</atitle><jtitle>J. Invest. Dermatol.; (United States)</jtitle><addtitle>J Invest Dermatol</addtitle><date>1988-10-01</date><risdate>1988</risdate><volume>91</volume><issue>4</issue><spage>303</spage><epage>308</epage><pages>303-308</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>Ultraviolet radiation B (UVB–290–320 nm) induces inflammation and hyperproliferation in human epidermis. This response is associated with the recovery from irradiated skin of inflammatory mediators derived from membrane phospholipids. We have previously reported that UVB stimulates the production of such mediators by human keratinocytes (HK) in culture. In these studies we examined the effect of UVB on the metabolism of choline containing phospholipids in HK prelabeled with [3H] choline. UVB (400–1600J/m2) stimulated a dose dependent release of [3H] choline from HK within minutes of irradiation. Examination of media extracts by paper chromatography revealed that the released [3H] choline was predominately in the form of glycerophosphorylcholine. Examination of label remaining in membranes of cells after irradiation by acid precipitation and HPLC revealed that the origin of the released [3H] choline was the membrane phosphatidylcholine/lysophosphatidylcholine. These data support a concept of UVB stimulation of both a phospholipase A (1 or 2) and a lysophospholipase. These UVB induced alterations of HK membrane phospholipid metabolism likely have profound effects on UVB-induced inflammation and control of cell growth in human skin.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>2459259</pmid><doi>10.1111/1523-1747.ep12475636</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | J. Invest. Dermatol.; (United States), 1988-10, Vol.91 (4), p.303-308 |
| issn | 0022-202X 1523-1747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78446352 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 550201 - Biochemistry- Tracer Techniques 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture ALCOHOLS AMINES AMMONIUM COMPOUNDS ANIMAL CELLS ANIMAL TISSUES ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY CARBOXYLESTERASES CELL CONSTITUENTS CELL MEMBRANES CELL PROLIFERATION Cells, Cultured CHOLINE CHROMATOGRAPHY Dermatology DOSE-RESPONSE RELATIONSHIPS DRUGS ELECTROMAGNETIC RADIATION ENZYMES Epidermal Cells EPIDERMIS Epidermis - metabolism Epidermis - radiation effects EPITHELIUM ESTERASES ESTERS Humans HYDROLASES HYDROXY COMPOUNDS Injuries of the skin. Diseases of the skin due to physical agents ISOTOPE APPLICATIONS KERATIN Keratins Kinetics LABELLED COMPOUNDS LIPASE LIPIDS LIPOTROPIC FACTORS LIQUID COLUMN CHROMATOGRAPHY MAMMALS MAN Medical sciences Membrane Lipids - metabolism MEMBRANE PROTEINS MEMBRANES METABOLISM ORGANIC COMPOUNDS ORGANIC PHOSPHORUS COMPOUNDS ORGANS Phosphatidylcholines - metabolism PHOSPHOLIPIDS PRIMATES PROTEINS QUATERNARY COMPOUNDS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS SCLEROPROTEINS SEPARATION PROCESSES SKIN TISSUES TRACER TECHNIQUES Traumas. Diseases due to physical agents TRITIUM COMPOUNDS ULTRAVIOLET RADIATION Ultraviolet Rays - adverse effects VERTEBRATES |
| title | Ultraviolet Radiation Alters Choline Phospholipid Metabolism in Human Keratinocytes |
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