Alcohol effects on the percentage of beta waves in the electroencephalograms of twins
Electroencephalogram (EEG) recordings were made from 26 pairs of monozygotic (MZ) and 26 pairs of dizygotic (DZ) adult male twins, before and after alcohol ingestion. After a baseline EEG and a light breakfast, 1.2 ml/kg of ethanol was given orally over 15 min and the EEG repeated four times at hour...
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| Veröffentlicht in: | Genetic epidemiology 1988, Vol.5 (4), p.217-224 |
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| creator | Christian, Joe C. Li, Ting-Kai Norton Jr, James A. Propping, Peter Yu, Pao-Lo Rao, D. C. |
| description | Electroencephalogram (EEG) recordings were made from 26 pairs of monozygotic (MZ) and 26 pairs of dizygotic (DZ) adult male twins, before and after alcohol ingestion. After a baseline EEG and a light breakfast, 1.2 ml/kg of ethanol was given orally over 15 min and the EEG repeated four times at hourly intervals. Alcohol caused a significant drop in the percentage of beta waves (14–30 cycles/sec) during the 1st hr. For the percentage of beta waves in 38 pairs of twins with complete data, MZ twin beta‐wave intraclass correlations (RMZ) ranged between 0.85 and 0.91 before and after alcohol, but the DZ intraclass correlations (RDZ) started at 0.54 and fell to 0.05 at 2 hr after alcohol before recovering to baseline levels. These correlations resulted in heritability estimates [2(RMZ‐RDZ)] of 0.68 at baseline and 1.73 at 2 hr. A heritability of 1.43 was found for the 1st hr drop in percentage of beta waves (RMZ = 0.78, RDZ = 0.06). These unrealistically high heritabilities, due to RDZ's approaching 0.0, suggest a failure of assumptions in the linear twin model that was used. Also, these findings are similar to, but more exaggerated than, findings in resting EEG's and visually evoked EEG potentials of twins and are compatible with the influence of gene interactions. |
| doi_str_mv | 10.1002/gepi.1370050403 |
| format | Article |
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C.</creator><creatorcontrib>Christian, Joe C. ; Li, Ting-Kai ; Norton Jr, James A. ; Propping, Peter ; Yu, Pao-Lo ; Rao, D. C.</creatorcontrib><description>Electroencephalogram (EEG) recordings were made from 26 pairs of monozygotic (MZ) and 26 pairs of dizygotic (DZ) adult male twins, before and after alcohol ingestion. After a baseline EEG and a light breakfast, 1.2 ml/kg of ethanol was given orally over 15 min and the EEG repeated four times at hourly intervals. Alcohol caused a significant drop in the percentage of beta waves (14–30 cycles/sec) during the 1st hr. For the percentage of beta waves in 38 pairs of twins with complete data, MZ twin beta‐wave intraclass correlations (RMZ) ranged between 0.85 and 0.91 before and after alcohol, but the DZ intraclass correlations (RDZ) started at 0.54 and fell to 0.05 at 2 hr after alcohol before recovering to baseline levels. These correlations resulted in heritability estimates [2(RMZ‐RDZ)] of 0.68 at baseline and 1.73 at 2 hr. A heritability of 1.43 was found for the 1st hr drop in percentage of beta waves (RMZ = 0.78, RDZ = 0.06). These unrealistically high heritabilities, due to RDZ's approaching 0.0, suggest a failure of assumptions in the linear twin model that was used. 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C.</creatorcontrib><title>Alcohol effects on the percentage of beta waves in the electroencephalograms of twins</title><title>Genetic epidemiology</title><addtitle>Genet. Epidemiol</addtitle><description>Electroencephalogram (EEG) recordings were made from 26 pairs of monozygotic (MZ) and 26 pairs of dizygotic (DZ) adult male twins, before and after alcohol ingestion. After a baseline EEG and a light breakfast, 1.2 ml/kg of ethanol was given orally over 15 min and the EEG repeated four times at hourly intervals. Alcohol caused a significant drop in the percentage of beta waves (14–30 cycles/sec) during the 1st hr. For the percentage of beta waves in 38 pairs of twins with complete data, MZ twin beta‐wave intraclass correlations (RMZ) ranged between 0.85 and 0.91 before and after alcohol, but the DZ intraclass correlations (RDZ) started at 0.54 and fell to 0.05 at 2 hr after alcohol before recovering to baseline levels. These correlations resulted in heritability estimates [2(RMZ‐RDZ)] of 0.68 at baseline and 1.73 at 2 hr. A heritability of 1.43 was found for the 1st hr drop in percentage of beta waves (RMZ = 0.78, RDZ = 0.06). These unrealistically high heritabilities, due to RDZ's approaching 0.0, suggest a failure of assumptions in the linear twin model that was used. Also, these findings are similar to, but more exaggerated than, findings in resting EEG's and visually evoked EEG potentials of twins and are compatible with the influence of gene interactions.</description><subject>Adult</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Beta Rhythm</subject><subject>Biological and medical sciences</subject><subject>Electroencephalography</subject><subject>Ethanol - pharmacology</subject><subject>genetic interactions</subject><subject>heritability</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>repeated measures analysis</subject><subject>Toxicology</subject><subject>Twins</subject><issn>0741-0395</issn><issn>1098-2272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAUxC1EVbaFMyekXEC9pH3-imNxqvqxrVQBQlQcLcf7vBvwxsHOdul_T1ZZteICp3eY38wbDSFvKZxSAHa2xL49pVwBSBDAX5AZBV2XjCn2ksxACVoC1_IVOcr5BwClQstDcshppSWTM3J_HlxcxVCg9-iGXMSuGFZY9JgcdoNdYhF90eBgi619wFy0k45hpFPEzmG_siEuk13nHTps2y6_Jgfehoxv9veY3F9ffbu4Ke8-z28vzu9KJ4TkZVX5mjGxsF75xlvPWGOZo0xyxysOWoydFLpGKqFAoG-QLTwTEhYetKKCH5MPU26f4q8N5sGs2-wwBNth3GSjaiEqpmAET_4JUsnFjtV6RM8m1KWYc0Jv-tSubXo0FMxuc7Pb3DxvPjre7cM3zRoXT_x-5FF_v9dtdjb4ZDvX5udYzSWvFB25jxO3bQM-_u-tmV99uf2rRTm52zzg7ye3TT9NpbiS5vunubkUdS3mX6-N5n8AyruqJw</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Christian, Joe C.</creator><creator>Li, Ting-Kai</creator><creator>Norton Jr, James A.</creator><creator>Propping, Peter</creator><creator>Yu, Pao-Lo</creator><creator>Rao, D. C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Alcohol effects on the percentage of beta waves in the electroencephalograms of twins</title><author>Christian, Joe C. ; Li, Ting-Kai ; Norton Jr, James A. ; Propping, Peter ; Yu, Pao-Lo ; Rao, D. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4453-66f8224daf7fbfaf22ba2c1253c363094ffe7ecb574704efbe2df2450df097143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Beta Rhythm</topic><topic>Biological and medical sciences</topic><topic>Electroencephalography</topic><topic>Ethanol - pharmacology</topic><topic>genetic interactions</topic><topic>heritability</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>repeated measures analysis</topic><topic>Toxicology</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christian, Joe C.</creatorcontrib><creatorcontrib>Li, Ting-Kai</creatorcontrib><creatorcontrib>Norton Jr, James A.</creatorcontrib><creatorcontrib>Propping, Peter</creatorcontrib><creatorcontrib>Yu, Pao-Lo</creatorcontrib><creatorcontrib>Rao, D. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genetic epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christian, Joe C.</au><au>Li, Ting-Kai</au><au>Norton Jr, James A.</au><au>Propping, Peter</au><au>Yu, Pao-Lo</au><au>Rao, D. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol effects on the percentage of beta waves in the electroencephalograms of twins</atitle><jtitle>Genetic epidemiology</jtitle><addtitle>Genet. Epidemiol</addtitle><date>1988</date><risdate>1988</risdate><volume>5</volume><issue>4</issue><spage>217</spage><epage>224</epage><pages>217-224</pages><issn>0741-0395</issn><eissn>1098-2272</eissn><coden>GENYEX</coden><abstract>Electroencephalogram (EEG) recordings were made from 26 pairs of monozygotic (MZ) and 26 pairs of dizygotic (DZ) adult male twins, before and after alcohol ingestion. After a baseline EEG and a light breakfast, 1.2 ml/kg of ethanol was given orally over 15 min and the EEG repeated four times at hourly intervals. Alcohol caused a significant drop in the percentage of beta waves (14–30 cycles/sec) during the 1st hr. For the percentage of beta waves in 38 pairs of twins with complete data, MZ twin beta‐wave intraclass correlations (RMZ) ranged between 0.85 and 0.91 before and after alcohol, but the DZ intraclass correlations (RDZ) started at 0.54 and fell to 0.05 at 2 hr after alcohol before recovering to baseline levels. These correlations resulted in heritability estimates [2(RMZ‐RDZ)] of 0.68 at baseline and 1.73 at 2 hr. A heritability of 1.43 was found for the 1st hr drop in percentage of beta waves (RMZ = 0.78, RDZ = 0.06). These unrealistically high heritabilities, due to RDZ's approaching 0.0, suggest a failure of assumptions in the linear twin model that was used. Also, these findings are similar to, but more exaggerated than, findings in resting EEG's and visually evoked EEG potentials of twins and are compatible with the influence of gene interactions.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3169525</pmid><doi>10.1002/gepi.1370050403</doi><tpages>8</tpages></addata></record> |
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| ispartof | Genetic epidemiology, 1988, Vol.5 (4), p.217-224 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Alcoholism and acute alcohol poisoning Beta Rhythm Biological and medical sciences Electroencephalography Ethanol - pharmacology genetic interactions heritability Humans Male Medical sciences repeated measures analysis Toxicology Twins |
| title | Alcohol effects on the percentage of beta waves in the electroencephalograms of twins |
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