Defective receptor binding of low density lipoprotein from pigs possessing mutant apolipoprotein B alleles

We previously identified a defect in the in vivo catabolism of low density lipoprotein (LDL) from hypercholesterolemic pigs carrying a mutant apolipoprotein B allele. In the present studies, we examined the in vitro metabolism of mutant LDL in cultured pig fibroblasts. A 3-fold higher concentration...

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Veröffentlicht in:	The Journal of biological chemistry 1988-10, Vol.263 (30), p.15467-15473
Hauptverfasser:	Lowe, S W, Checovich, W J, Rapacz, J, Attie, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alleles Animals apolipoproteins Apolipoproteins B - genetics Biological and medical sciences Cell receptors Cell structures and functions cerdo Fundamental and applied biological sciences. Psychology gene genes lipoprotein (low density) lipoproteinas lipoproteine lipoproteins Lipoproteins, LDL - genetics Lipoproteins, LDL - metabolism Molecular and cellular biology mutant mutantes mutants Mutation porcin Receptors, LDL - metabolism Swine
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