Inosine Mediates the Protective Effect of Adenosine in Rat Astrocyte Cultures Subjected to Combined Glucose‐Oxygen Deprivation

: Preliminary evidence suggests adenosine, a neuromodulator, has neuroprotective properties during cerebral ischemia. It is unclear, however, if adenosine has glioprotective effects. We studied the effect of adenosine on cellular injury in astroglial cultures subjected to combined glucose‐oxygen dep...

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Veröffentlicht in:	Journal of neurochemistry 1996-11, Vol.67 (5), p.2051-2059
Hauptverfasser:	Haun, Steven E., Segeleon, Joseph E., Trapp, Victoria L., Clotz, Michael A., Horrocks, Lloyd A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Chloroadenosine - pharmacology Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine-5'-(N-ethylcarboxamide) Animals Animals, Newborn Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cell death Cell Hypoxia Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - metabolism Fundamental and applied biological sciences. Psychology Glucose - metabolism Hypoxia Inosine - pharmacology Ischemia Isolated neuron and nerve. Neuroglia Kinetics L-Lactate Dehydrogenase - analysis Purines - metabolism Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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