DR and DQ beta cDNA sequences associated with a DR2 haplotype
Three cDNA clones encoding a DQ beta and two DR beta polypeptides have been isolated and sequenced from an American black individual expressing a DR2,DQw1 haplotype. The sequences of the cDNA clones are identical to previously described DR and DQ sequences from a DR2,Dw2 cell. The differences betwee...
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| Veröffentlicht in: | Human immunology 1988-07, Vol.22 (3), p.179-183 |
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| container_end_page | 183 |
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| container_issue | 3 |
| container_start_page | 179 |
| container_title | Human immunology |
| container_volume | 22 |
| creator | Katovich Hurley, Carolyn Ziff, Barbara L. Steiner, Noriko Gregersen, Peter K. Silver, Jack |
| description | Three cDNA clones encoding a DQ beta and two DR beta polypeptides have been isolated and sequenced from an American black individual expressing a DR2,DQw1 haplotype. The sequences of the cDNA clones are identical to previously described DR and DQ sequences from a DR2,Dw2 cell. The differences between DQw1-associated beta chains from DR2 and DR1 haplotypes is substantial, although a DQw1-specific sequence can be identified. The identical DQ and DR beta sequences found in unrelated individuals from different racial backgrounds suggests that class II structural polymorphism within the human population will be limited. |
| doi_str_mv | 10.1016/0198-8859(88)90027-4 |
| format | Article |
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The sequences of the cDNA clones are identical to previously described DR and DQ sequences from a DR2,Dw2 cell. The differences between DQw1-associated beta chains from DR2 and DR1 haplotypes is substantial, although a DQw1-specific sequence can be identified. The identical DQ and DR beta sequences found in unrelated individuals from different racial backgrounds suggests that class II structural polymorphism within the human population will be limited.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/0198-8859(88)90027-4</identifier><identifier>PMID: 3139589</identifier><identifier>CODEN: HUIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Antigens ; Base Sequence ; Biological and medical sciences ; DNA - genetics ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genes, MHC Class II ; Haplotypes ; Histocompatibility antigens (hla, h-2 and other systems) ; HLA-DQ Antigens - genetics ; HLA-DR Antigens - genetics ; HLA-DR2 Antigen ; Humans ; Molecular immunology ; Molecular Sequence Data ; Polymorphism, Genetic</subject><ispartof>Human immunology, 1988-07, Vol.22 (3), p.179-183</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-c311730619482b5f616282611b34dfb07f4cc27d797e1f388518c2e7d7616ef63</citedby><cites>FETCH-LOGICAL-c332t-c311730619482b5f616282611b34dfb07f4cc27d797e1f388518c2e7d7616ef63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0198885988900274$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6599374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3139589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katovich Hurley, Carolyn</creatorcontrib><creatorcontrib>Ziff, Barbara L.</creatorcontrib><creatorcontrib>Steiner, Noriko</creatorcontrib><creatorcontrib>Gregersen, Peter K.</creatorcontrib><creatorcontrib>Silver, Jack</creatorcontrib><title>DR and DQ beta cDNA sequences associated with a DR2 haplotype</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Three cDNA clones encoding a DQ beta and two DR beta polypeptides have been isolated and sequenced from an American black individual expressing a DR2,DQw1 haplotype. The sequences of the cDNA clones are identical to previously described DR and DQ sequences from a DR2,Dw2 cell. The differences between DQw1-associated beta chains from DR2 and DR1 haplotypes is substantial, although a DQw1-specific sequence can be identified. The identical DQ and DR beta sequences found in unrelated individuals from different racial backgrounds suggests that class II structural polymorphism within the human population will be limited.</description><subject>Amino Acid Sequence</subject><subject>Antigens</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes, MHC Class II</subject><subject>Haplotypes</subject><subject>Histocompatibility antigens (hla, h-2 and other systems)</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR2 Antigen</subject><subject>Humans</subject><subject>Molecular immunology</subject><subject>Molecular Sequence Data</subject><subject>Polymorphism, Genetic</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhi1UlAbKP6CSD1VFD0s9ttcfB5AQKR8SAhGVs-X1zgpXm2xYb4r493ibKEd6GUueZ0bvPIQcAzsFBuonA2sKY0p7YswPyxjXhdwjUzDaFgBKfSLTHfKZHKT0hzGmmZYTMhEgbGnslJzN5tQvazp7pBUOnobZ_QVN-LLGZcBEfUpdiH7Amr7G4Zl6Optz-uxXbTe8rfAL2W98m_Bo-x6Sp6tfvy9viruH69vLi7siCMGHXAG0YAqsNLwqGwWKG64AKiHrpmK6kSFwXWurERqRA4MJHPNHJrFR4pB83-xd9V2Olga3iClg2_olduvktJFS5uP-C0LJuGXCZlBuwNB3KfXYuFUfF75_c8DcqNeN7tzoLhf3T6-Teezrdv-6WmC9G9r6zP1v275PwbdN75chph2mSmuFHtecbzDM0v5G7F0KcTRexx7D4OoufpzjHUERkkg</recordid><startdate>198807</startdate><enddate>198807</enddate><creator>Katovich Hurley, Carolyn</creator><creator>Ziff, Barbara L.</creator><creator>Steiner, Noriko</creator><creator>Gregersen, Peter K.</creator><creator>Silver, Jack</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>198807</creationdate><title>DR and DQ beta cDNA sequences associated with a DR2 haplotype</title><author>Katovich Hurley, Carolyn ; Ziff, Barbara L. ; Steiner, Noriko ; Gregersen, Peter K. ; Silver, Jack</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-c311730619482b5f616282611b34dfb07f4cc27d797e1f388518c2e7d7616ef63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Antigens</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>DNA - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes, MHC Class II</topic><topic>Haplotypes</topic><topic>Histocompatibility antigens (hla, h-2 and other systems)</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR2 Antigen</topic><topic>Humans</topic><topic>Molecular immunology</topic><topic>Molecular Sequence Data</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katovich Hurley, Carolyn</creatorcontrib><creatorcontrib>Ziff, Barbara L.</creatorcontrib><creatorcontrib>Steiner, Noriko</creatorcontrib><creatorcontrib>Gregersen, Peter K.</creatorcontrib><creatorcontrib>Silver, Jack</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katovich Hurley, Carolyn</au><au>Ziff, Barbara L.</au><au>Steiner, Noriko</au><au>Gregersen, Peter K.</au><au>Silver, Jack</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DR and DQ beta cDNA sequences associated with a DR2 haplotype</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>1988-07</date><risdate>1988</risdate><volume>22</volume><issue>3</issue><spage>179</spage><epage>183</epage><pages>179-183</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><coden>HUIMDQ</coden><abstract>Three cDNA clones encoding a DQ beta and two DR beta polypeptides have been isolated and sequenced from an American black individual expressing a DR2,DQw1 haplotype. The sequences of the cDNA clones are identical to previously described DR and DQ sequences from a DR2,Dw2 cell. The differences between DQw1-associated beta chains from DR2 and DR1 haplotypes is substantial, although a DQw1-specific sequence can be identified. The identical DQ and DR beta sequences found in unrelated individuals from different racial backgrounds suggests that class II structural polymorphism within the human population will be limited.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3139589</pmid><doi>10.1016/0198-8859(88)90027-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human immunology, 1988-07, Vol.22 (3), p.179-183 |
| issn | 0198-8859 1879-1166 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Antigens Base Sequence Biological and medical sciences DNA - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, MHC Class II Haplotypes Histocompatibility antigens (hla, h-2 and other systems) HLA-DQ Antigens - genetics HLA-DR Antigens - genetics HLA-DR2 Antigen Humans Molecular immunology Molecular Sequence Data Polymorphism, Genetic |
| title | DR and DQ beta cDNA sequences associated with a DR2 haplotype |
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