Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders
The polymorphism of HLA‐DRBI, ‐DRB3, and ‐DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty‐three patients clinically displayed selective involvement of the optic nerve and spinal cord and were class...
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| Veröffentlicht in: | Annals of neurology 1996-10, Vol.40 (4), p.569-574 |
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| container_end_page | 574 |
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| container_issue | 4 |
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| container_title | Annals of neurology |
| container_volume | 40 |
| creator | Yamasaki, Kenji Kira, Jun-Ichi Kawano, Yuji Kobayashi, Takuro Kanai, Takayuki Nishimura, Yasuhara Matsushita, Sho Hasuo, Kanehiro Tobimatsu, Shozo |
| description | The polymorphism of HLA‐DRBI, ‐DRB3, and ‐DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty‐three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian‐type MS. Patients with Asian‐type MS had fewer brain lesions shown gy magnetic resonance imaging, but more gadolinium‐enhanced spinal cord lesions than did patients with Western‐type MS (47% vs 17%). Fruthermore, the DR2‐associated DRBI1501 allele and DRB50101 allele were associated with Western‐type MS (41.2%), but not with either Asian‐type MS (0%) or healthy control subjects (14.2%). Heterogeneity inthe immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians. |
| doi_str_mv | 10.1002/ana.410400405 |
| format | Article |
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Twenty‐three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian‐type MS. Patients with Asian‐type MS had fewer brain lesions shown gy magnetic resonance imaging, but more gadolinium‐enhanced spinal cord lesions than did patients with Western‐type MS (47% vs 17%). Fruthermore, the DR2‐associated DRBI1501 allele and DRB50101 allele were associated with Western‐type MS (41.2%), but not with either Asian‐type MS (0%) or healthy control subjects (14.2%). Heterogeneity inthe immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410400405</identifier><identifier>PMID: 8871575</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Boston: Little Brown and Company</publisher><subject>Alleles ; Biological and medical sciences ; Brain - physiopathology ; Female ; Gene Amplification ; HLA-DR Antigens - genetics ; HLA-DR Antigens - immunology ; Humans ; Japan ; Magnetic Resonance Imaging ; Major Histocompatibility Complex ; Male ; Medical sciences ; Multiple Sclerosis - genetics ; Multiple Sclerosis - immunology ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Optic Nerve - physiopathology ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Retrospective Studies ; Spinal Cord - physiopathology</subject><ispartof>Annals of neurology, 1996-10, Vol.40 (4), p.569-574</ispartof><rights>Copyright © 1996 American Neurological Association</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4695-be1fa65fe70ed9396b4ce82b8805b8753c9b7fd418a6e1bb0d13c8d56a0c5e8a3</citedby><cites>FETCH-LOGICAL-c4695-be1fa65fe70ed9396b4ce82b8805b8753c9b7fd418a6e1bb0d13c8d56a0c5e8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410400405$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410400405$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2474770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8871575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamasaki, Kenji</creatorcontrib><creatorcontrib>Kira, Jun-Ichi</creatorcontrib><creatorcontrib>Kawano, Yuji</creatorcontrib><creatorcontrib>Kobayashi, Takuro</creatorcontrib><creatorcontrib>Kanai, Takayuki</creatorcontrib><creatorcontrib>Nishimura, Yasuhara</creatorcontrib><creatorcontrib>Matsushita, Sho</creatorcontrib><creatorcontrib>Hasuo, Kanehiro</creatorcontrib><creatorcontrib>Tobimatsu, Shozo</creatorcontrib><title>Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>The polymorphism of HLA‐DRBI, ‐DRB3, and ‐DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty‐three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian‐type MS. Patients with Asian‐type MS had fewer brain lesions shown gy magnetic resonance imaging, but more gadolinium‐enhanced spinal cord lesions than did patients with Western‐type MS (47% vs 17%). Fruthermore, the DR2‐associated DRBI1501 allele and DRB50101 allele were associated with Western‐type MS (41.2%), but not with either Asian‐type MS (0%) or healthy control subjects (14.2%). Heterogeneity inthe immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.</description><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Female</subject><subject>Gene Amplification</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Japan</subject><subject>Magnetic Resonance Imaging</subject><subject>Major Histocompatibility Complex</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Optic Nerve - physiopathology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Retrospective Studies</subject><subject>Spinal Cord - physiopathology</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGP1CAUh4nRrOPq0aMJB-OtKxQo1Nu4cdeNk_WimSOh9NWglI68Vp3_XjbTTDyZkAB5Hz_e-wh5ydkVZ6x-65K7kpxJVpZ6RDZcCV6ZWraPyYaJRlaKC_mUPEP8zhhrG84uyIUxmiutNgT2gDPkRH9BxgWpw-ASnY8HQDoNdFziHA4RKPoIecKA7-jdOC5p-gYJ5uBdjEfqUk99DGm99gHnkPz8cJhyX4KfkyeDiwgv1v2SfL358OX6Y7X7fHt3vd1VXjatqjrgg2vUAJpB34q26aQHU3fGMNUZrYRvOz30khvXAO861nPhTa8ax7wC48QleXPKPeTp51Ims2NADzG6BNOCVhspa6N0AasT6MtQmGGwhxxGl4-WM_ug1Rat9qy18K_W4KUboT_Tq8dSf73WHRYJQ3bJBzxjtdRSa1YwfcJ-hwjH__9pt_fbfxtYGy5u4c_5pcs_bKOFVnZ_f2v3n1R7w3fvrRJ_AR-BoV8</recordid><startdate>199610</startdate><enddate>199610</enddate><creator>Yamasaki, Kenji</creator><creator>Kira, Jun-Ichi</creator><creator>Kawano, Yuji</creator><creator>Kobayashi, Takuro</creator><creator>Kanai, Takayuki</creator><creator>Nishimura, Yasuhara</creator><creator>Matsushita, Sho</creator><creator>Hasuo, Kanehiro</creator><creator>Tobimatsu, Shozo</creator><general>Little Brown and Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199610</creationdate><title>Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders</title><author>Yamasaki, Kenji ; Kira, Jun-Ichi ; Kawano, Yuji ; Kobayashi, Takuro ; Kanai, Takayuki ; Nishimura, Yasuhara ; Matsushita, Sho ; Hasuo, Kanehiro ; Tobimatsu, Shozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4695-be1fa65fe70ed9396b4ce82b8805b8753c9b7fd418a6e1bb0d13c8d56a0c5e8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Brain - physiopathology</topic><topic>Female</topic><topic>Gene Amplification</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR Antigens - immunology</topic><topic>Humans</topic><topic>Japan</topic><topic>Magnetic Resonance Imaging</topic><topic>Major Histocompatibility Complex</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Sclerosis - genetics</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Optic Nerve - physiopathology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Retrospective Studies</topic><topic>Spinal Cord - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamasaki, Kenji</creatorcontrib><creatorcontrib>Kira, Jun-Ichi</creatorcontrib><creatorcontrib>Kawano, Yuji</creatorcontrib><creatorcontrib>Kobayashi, Takuro</creatorcontrib><creatorcontrib>Kanai, Takayuki</creatorcontrib><creatorcontrib>Nishimura, Yasuhara</creatorcontrib><creatorcontrib>Matsushita, Sho</creatorcontrib><creatorcontrib>Hasuo, Kanehiro</creatorcontrib><creatorcontrib>Tobimatsu, Shozo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamasaki, Kenji</au><au>Kira, Jun-Ichi</au><au>Kawano, Yuji</au><au>Kobayashi, Takuro</au><au>Kanai, Takayuki</au><au>Nishimura, Yasuhara</au><au>Matsushita, Sho</au><au>Hasuo, Kanehiro</au><au>Tobimatsu, Shozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1996-10</date><risdate>1996</risdate><volume>40</volume><issue>4</issue><spage>569</spage><epage>574</epage><pages>569-574</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>The polymorphism of HLA‐DRBI, ‐DRB3, and ‐DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty‐three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian‐type MS. Patients with Asian‐type MS had fewer brain lesions shown gy magnetic resonance imaging, but more gadolinium‐enhanced spinal cord lesions than did patients with Western‐type MS (47% vs 17%). Fruthermore, the DR2‐associated DRBI1501 allele and DRB50101 allele were associated with Western‐type MS (41.2%), but not with either Asian‐type MS (0%) or healthy control subjects (14.2%). Heterogeneity inthe immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.</abstract><cop>Boston</cop><pub>Little Brown and Company</pub><pmid>8871575</pmid><doi>10.1002/ana.410400405</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of neurology, 1996-10, Vol.40 (4), p.569-574 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alleles Biological and medical sciences Brain - physiopathology Female Gene Amplification HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Japan Magnetic Resonance Imaging Major Histocompatibility Complex Male Medical sciences Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Optic Nerve - physiopathology Polymerase Chain Reaction Polymorphism, Genetic Retrospective Studies Spinal Cord - physiopathology |
| title | Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders |
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