Studies on the immunomodulatory effects of Ashwagandha
The immunomodulatory activity of an Indian Ayurvedic medicinal preparation, Ashwagandna ( Withania somnifera (L. Dunal)) was studied in mice with myelosuppression induced by one or more of the following three compounds: cyclophosphamide, azathioprin, or prednisolone. The assessment of immunomodulato...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 1996-02, Vol.50 (2), p.69-76 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 76 |
|---|---|
| container_issue | 2 |
| container_start_page | 69 |
| container_title | Journal of ethnopharmacology |
| container_volume | 50 |
| creator | Ziauddin, Mohammed Phansalkar, Neeta Patki, Pralhad Diwanay, Sham Patwardhan, Bhushan |
| description | The immunomodulatory activity of an Indian Ayurvedic medicinal preparation, Ashwagandna (
Withania somnifera (L. Dunal)) was studied in mice with myelosuppression induced by one or more of the following three compounds: cyclophosphamide, azathioprin, or prednisolone. The assessment of immunomodulatory activity was carried out by hematological and serological tests. A significant modulation of immune reactivity was observed in all the three animal models used. Ashwagandha prevented myelosuppression in mice treated with all three immunosuppressive drugs tested. A significant increase in hemoglobin concentration (
P < 0.01), red blood cell count (
P < 0.01), white blood cell count (
P < 0.05), platelet count (
P < 0.01), and body weight (
P < 0.05) was observed in Ashwagandha-treated mice as compared with untreated (control) mice. We also report an immunostimulatory activity: treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes. |
| doi_str_mv | 10.1016/0378-8741(95)01318-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78442258</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0378874195013180</els_id><sourcerecordid>78442258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-318d251ca5f264c19b74ce14ed6694ba683e560ec6fa06a8d3bb737502c03f023</originalsourceid><addsrcrecordid>eNp9kEtv1DAURi0EKtOBfwAiC4RgEbh-O5tKVVUeUiUWpWvLsa87QUlc7ATUf4-HGc2S1ZXud-5Dh5BXFD5SoOoTcG1aowV938kPQDk1LTwhG2o0a7XU_CnZnJDn5LyUnwCgqYAzcmaMUpqpDVG3yxoGLE2am2WHzTBN65ymFNbRLSk_Nhgj-qXmsbksuz_u3s1h516QZ9GNBV8e65bcfb7-cfW1vfn-5dvV5U3rhVZLW38KTFLvZGRKeNr1WnikAoNSneidMhylAvQqOlDOBN73mmsJzAOPwPiWvDvsfcjp14plsdNQPI6jmzGtxWojBGPSVFAcQJ9TKRmjfcjD5PKjpWD3uuzehd27sJ20_3TV1pa8Pu5f-wnDaejop-Zvj7kr3o0xu9kP5YRxAKFYV7E3Byy6ZN19rsjdLatHgEoqOiorcXEgsNr6PWC2xQ84ewxDrn5tSMP_P_0Luz6OGw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78442258</pqid></control><display><type>article</type><title>Studies on the immunomodulatory effects of Ashwagandha</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ziauddin, Mohammed ; Phansalkar, Neeta ; Patki, Pralhad ; Diwanay, Sham ; Patwardhan, Bhushan</creator><creatorcontrib>Ziauddin, Mohammed ; Phansalkar, Neeta ; Patki, Pralhad ; Diwanay, Sham ; Patwardhan, Bhushan</creatorcontrib><description>The immunomodulatory activity of an Indian Ayurvedic medicinal preparation, Ashwagandna (
Withania somnifera (L. Dunal)) was studied in mice with myelosuppression induced by one or more of the following three compounds: cyclophosphamide, azathioprin, or prednisolone. The assessment of immunomodulatory activity was carried out by hematological and serological tests. A significant modulation of immune reactivity was observed in all the three animal models used. Ashwagandha prevented myelosuppression in mice treated with all three immunosuppressive drugs tested. A significant increase in hemoglobin concentration (
P < 0.01), red blood cell count (
P < 0.01), white blood cell count (
P < 0.05), platelet count (
P < 0.01), and body weight (
P < 0.05) was observed in Ashwagandha-treated mice as compared with untreated (control) mice. We also report an immunostimulatory activity: treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/0378-8741(95)01318-0</identifier><identifier>PMID: 8866726</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antibodies - immunology ; Ashwagandha ; Ayurvedic medicine ; Biological and medical sciences ; Cell Count - drug effects ; drugs ; Erythrocytes - drug effects ; General pharmacology ; Hemodynamics - drug effects ; Immunization ; Immunomodulation ; immunostimulants ; Immunostimulation ; Medical sciences ; Medicine, Ayurvedic ; Mice ; Mice, Inbred Strains ; Myelosuppression ; myelosuppressive drugs ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - pharmacology ; roots ; traditional medicine ; Withania somnifera</subject><ispartof>Journal of ethnopharmacology, 1996-02, Vol.50 (2), p.69-76</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-318d251ca5f264c19b74ce14ed6694ba683e560ec6fa06a8d3bb737502c03f023</citedby><cites>FETCH-LOGICAL-c476t-318d251ca5f264c19b74ce14ed6694ba683e560ec6fa06a8d3bb737502c03f023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-8741(95)01318-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3004629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8866726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ziauddin, Mohammed</creatorcontrib><creatorcontrib>Phansalkar, Neeta</creatorcontrib><creatorcontrib>Patki, Pralhad</creatorcontrib><creatorcontrib>Diwanay, Sham</creatorcontrib><creatorcontrib>Patwardhan, Bhushan</creatorcontrib><title>Studies on the immunomodulatory effects of Ashwagandha</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The immunomodulatory activity of an Indian Ayurvedic medicinal preparation, Ashwagandna (
Withania somnifera (L. Dunal)) was studied in mice with myelosuppression induced by one or more of the following three compounds: cyclophosphamide, azathioprin, or prednisolone. The assessment of immunomodulatory activity was carried out by hematological and serological tests. A significant modulation of immune reactivity was observed in all the three animal models used. Ashwagandha prevented myelosuppression in mice treated with all three immunosuppressive drugs tested. A significant increase in hemoglobin concentration (
P < 0.01), red blood cell count (
P < 0.01), white blood cell count (
P < 0.05), platelet count (
P < 0.01), and body weight (
P < 0.05) was observed in Ashwagandha-treated mice as compared with untreated (control) mice. We also report an immunostimulatory activity: treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes.</description><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Ashwagandha</subject><subject>Ayurvedic medicine</subject><subject>Biological and medical sciences</subject><subject>Cell Count - drug effects</subject><subject>drugs</subject><subject>Erythrocytes - drug effects</subject><subject>General pharmacology</subject><subject>Hemodynamics - drug effects</subject><subject>Immunization</subject><subject>Immunomodulation</subject><subject>immunostimulants</subject><subject>Immunostimulation</subject><subject>Medical sciences</subject><subject>Medicine, Ayurvedic</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Myelosuppression</subject><subject>myelosuppressive drugs</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>roots</subject><subject>traditional medicine</subject><subject>Withania somnifera</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAURi0EKtOBfwAiC4RgEbh-O5tKVVUeUiUWpWvLsa87QUlc7ATUf4-HGc2S1ZXud-5Dh5BXFD5SoOoTcG1aowV938kPQDk1LTwhG2o0a7XU_CnZnJDn5LyUnwCgqYAzcmaMUpqpDVG3yxoGLE2am2WHzTBN65ymFNbRLSk_Nhgj-qXmsbksuz_u3s1h516QZ9GNBV8e65bcfb7-cfW1vfn-5dvV5U3rhVZLW38KTFLvZGRKeNr1WnikAoNSneidMhylAvQqOlDOBN73mmsJzAOPwPiWvDvsfcjp14plsdNQPI6jmzGtxWojBGPSVFAcQJ9TKRmjfcjD5PKjpWD3uuzehd27sJ20_3TV1pa8Pu5f-wnDaejop-Zvj7kr3o0xu9kP5YRxAKFYV7E3Byy6ZN19rsjdLatHgEoqOiorcXEgsNr6PWC2xQ84ewxDrn5tSMP_P_0Luz6OGw</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Ziauddin, Mohammed</creator><creator>Phansalkar, Neeta</creator><creator>Patki, Pralhad</creator><creator>Diwanay, Sham</creator><creator>Patwardhan, Bhushan</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Studies on the immunomodulatory effects of Ashwagandha</title><author>Ziauddin, Mohammed ; Phansalkar, Neeta ; Patki, Pralhad ; Diwanay, Sham ; Patwardhan, Bhushan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-318d251ca5f264c19b74ce14ed6694ba683e560ec6fa06a8d3bb737502c03f023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Ashwagandha</topic><topic>Ayurvedic medicine</topic><topic>Biological and medical sciences</topic><topic>Cell Count - drug effects</topic><topic>drugs</topic><topic>Erythrocytes - drug effects</topic><topic>General pharmacology</topic><topic>Hemodynamics - drug effects</topic><topic>Immunization</topic><topic>Immunomodulation</topic><topic>immunostimulants</topic><topic>Immunostimulation</topic><topic>Medical sciences</topic><topic>Medicine, Ayurvedic</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Myelosuppression</topic><topic>myelosuppressive drugs</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>roots</topic><topic>traditional medicine</topic><topic>Withania somnifera</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ziauddin, Mohammed</creatorcontrib><creatorcontrib>Phansalkar, Neeta</creatorcontrib><creatorcontrib>Patki, Pralhad</creatorcontrib><creatorcontrib>Diwanay, Sham</creatorcontrib><creatorcontrib>Patwardhan, Bhushan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ziauddin, Mohammed</au><au>Phansalkar, Neeta</au><au>Patki, Pralhad</au><au>Diwanay, Sham</au><au>Patwardhan, Bhushan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the immunomodulatory effects of Ashwagandha</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>50</volume><issue>2</issue><spage>69</spage><epage>76</epage><pages>69-76</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The immunomodulatory activity of an Indian Ayurvedic medicinal preparation, Ashwagandna (
Withania somnifera (L. Dunal)) was studied in mice with myelosuppression induced by one or more of the following three compounds: cyclophosphamide, azathioprin, or prednisolone. The assessment of immunomodulatory activity was carried out by hematological and serological tests. A significant modulation of immune reactivity was observed in all the three animal models used. Ashwagandha prevented myelosuppression in mice treated with all three immunosuppressive drugs tested. A significant increase in hemoglobin concentration (
P < 0.01), red blood cell count (
P < 0.01), white blood cell count (
P < 0.05), platelet count (
P < 0.01), and body weight (
P < 0.05) was observed in Ashwagandha-treated mice as compared with untreated (control) mice. We also report an immunostimulatory activity: treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8866726</pmid><doi>10.1016/0378-8741(95)01318-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 1996-02, Vol.50 (2), p.69-76 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78442258 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antibodies - immunology Ashwagandha Ayurvedic medicine Biological and medical sciences Cell Count - drug effects drugs Erythrocytes - drug effects General pharmacology Hemodynamics - drug effects Immunization Immunomodulation immunostimulants Immunostimulation Medical sciences Medicine, Ayurvedic Mice Mice, Inbred Strains Myelosuppression myelosuppressive drugs Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology roots traditional medicine Withania somnifera |
| title | Studies on the immunomodulatory effects of Ashwagandha |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A52%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20the%20immunomodulatory%20effects%20of%20Ashwagandha&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Ziauddin,%20Mohammed&rft.date=1996-02-01&rft.volume=50&rft.issue=2&rft.spage=69&rft.epage=76&rft.pages=69-76&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/0378-8741(95)01318-0&rft_dat=%3Cproquest_cross%3E78442258%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78442258&rft_id=info:pmid/8866726&rft_els_id=0378874195013180&rfr_iscdi=true |