Differential effects of ventral striatal lesions on the conditioned place preference induced by morphine or amphetamine
The present experiment examined the role of the ventral striatum in the rewarding effect of morphine and amphetamine by testing whether lesions of cell bodies within this region disrupt the development of a conditioned place preference to either drug. Bilateral, N-methyl- d-aspartate- or kainic acid...
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| Veröffentlicht in: | Neuroscience 1996-04, Vol.71 (3), p.701-708 |
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| creator | Olmstead, M.C. Franklin, K.B.J. |
| description | The present experiment examined the role of the ventral striatum in the rewarding effect of morphine and amphetamine by testing whether lesions of cell bodies within this region disrupt the development of a conditioned place preference to either drug. Bilateral,
N-methyl-
d-aspartate- or kainic acid-induced lesions of the ventral striatum block a conditioned place preference to amphetamine (1.5 mg/kg × 3 pairings) but not to morphine (2 mg/kg × 3 pairings). Because both lesions spared anterior portions of the ventral striatum, we examined the effect of larger or more selective ventral striatal lesions on a conditioned place preference induced by morphine. Destruction of the entire ventral striatum reduced, but did not eliminate, a conditioned place preference to morphine, whereas selective lesions of the anterior ventral striatum were ineffective.
These results indicate that the ventral striatum is not critically involved in morphine's rewarding effect and support the suggestion that the rewarding effects of opiates and stimulants do not involve identical neural substrates. |
| doi_str_mv | 10.1016/0306-4522(95)00486-6 |
| format | Article |
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These results indicate that the ventral striatum is not critically involved in morphine's rewarding effect and support the suggestion that the rewarding effects of opiates and stimulants do not involve identical neural substrates.</description><subject>Amphetamine - pharmacology</subject><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - physiology</subject><subject>drug dependence</subject><subject>excitotoxin lesions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>opiates</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>opiates</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>psychostimulants</topic><topic>Rats</topic><topic>reinforcement</topic><topic>Reward</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olmstead, M.C.</creatorcontrib><creatorcontrib>Franklin, K.B.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olmstead, M.C.</au><au>Franklin, K.B.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of ventral striatal lesions on the conditioned place preference induced by morphine or amphetamine</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>71</volume><issue>3</issue><spage>701</spage><epage>708</epage><pages>701-708</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The present experiment examined the role of the ventral striatum in the rewarding effect of morphine and amphetamine by testing whether lesions of cell bodies within this region disrupt the development of a conditioned place preference to either drug. 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N-methyl-
d-aspartate- or kainic acid-induced lesions of the ventral striatum block a conditioned place preference to amphetamine (1.5 mg/kg × 3 pairings) but not to morphine (2 mg/kg × 3 pairings). Because both lesions spared anterior portions of the ventral striatum, we examined the effect of larger or more selective ventral striatal lesions on a conditioned place preference induced by morphine. Destruction of the entire ventral striatum reduced, but did not eliminate, a conditioned place preference to morphine, whereas selective lesions of the anterior ventral striatum were ineffective.
These results indicate that the ventral striatum is not critically involved in morphine's rewarding effect and support the suggestion that the rewarding effects of opiates and stimulants do not involve identical neural substrates.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8867042</pmid><doi>10.1016/0306-4522(95)00486-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience, 1996-04, Vol.71 (3), p.701-708 |
| issn | 0306-4522 1873-7544 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amphetamine - pharmacology Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Conditioning (Psychology) - drug effects Corpus Striatum - drug effects Corpus Striatum - physiology drug dependence excitotoxin lesions Fundamental and applied biological sciences. Psychology Male Morphine - pharmacology opiates Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology psychostimulants Rats reinforcement Reward |
| title | Differential effects of ventral striatal lesions on the conditioned place preference induced by morphine or amphetamine |
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