Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1

Following ocular infection, herpes simplex virus type 1 (HSV-1) establishes latency in trigeminal ganglion (TG) neurons. Using reverse transcription-PCR, cytokine gene expression was analyzed in the TGs of mice infected with HSV-1. IL-2, TNF-alpha, IFN-gamma, IL-10, and RANTES mRNAs were readily det...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-10, Vol.157 (8), p.3542-3549
Hauptverfasser:	Halford, WP, Gebhardt, BM, Carr, DJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Base Sequence Cell Line Cercopithecus aethiops Chemokine CCL5 - genetics Cytokines - genetics DNA Primers - genetics Female Gene Expression herpes simplex virus 1 Herpesvirus 1, Human - immunology Herpesvirus 1, Human - pathogenicity Interferon-gamma - genetics Interleukin-10 - genetics Interleukin-2 - genetics Keratitis, Herpetic - immunology Keratitis, Herpetic - metabolism Keratitis, Herpetic - virology Mice Mice, Inbred ICR RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors Trigeminal Ganglion - immunology Trigeminal Ganglion - metabolism Trigeminal Ganglion - virology Tumor Necrosis Factor-alpha - genetics Vero Cells
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