UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues
UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources....
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| Veröffentlicht in: | Cell 1996-10, Vol.87 (2), p.187-195 |
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| creator | Chan, S.S.-Y. Zheng, H. Su, M.-W. Wilk, R. Killeen, M.T. Hedgecock, E.M. Culotti, J.G. |
| description | UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells. |
| doi_str_mv | 10.1016/S0092-8674(00)81337-9 |
| format | Article |
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UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(00)81337-9</identifier><identifier>PMID: 8861903</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; caenorhabditis elegans ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - growth & development ; Caenorhabditis elegans Proteins ; Cell Adhesion Molecules - physiology ; Cell Movement ; Cloning, Molecular ; Gene Expression Regulation, Developmental ; Genes, Helminth ; Membrane Proteins - genetics ; Molecular Sequence Data ; Nerve Growth Factors - physiology ; Nervous System - embryology ; Netrin-1 ; Neurons - metabolism ; Receptors, Cell Surface - physiology ; RNA, Helminth - genetics ; Sequence Alignment ; Signal Transduction ; Tumor Suppressor Proteins</subject><ispartof>Cell, 1996-10, Vol.87 (2), p.187-195</ispartof><rights>1996 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-612790cf934d20eb6580c94425e5508076e0cd8325b98f0a28c63163af1c1bff3</citedby><cites>FETCH-LOGICAL-c556t-612790cf934d20eb6580c94425e5508076e0cd8325b98f0a28c63163af1c1bff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867400813379$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8861903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, S.S.-Y.</creatorcontrib><creatorcontrib>Zheng, H.</creatorcontrib><creatorcontrib>Su, M.-W.</creatorcontrib><creatorcontrib>Wilk, R.</creatorcontrib><creatorcontrib>Killeen, M.T.</creatorcontrib><creatorcontrib>Hedgecock, E.M.</creatorcontrib><creatorcontrib>Culotti, J.G.</creatorcontrib><title>UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues</title><title>Cell</title><addtitle>Cell</addtitle><description>UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>caenorhabditis elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Caenorhabditis elegans Proteins</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Cell Movement</subject><subject>Cloning, Molecular</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Helminth</subject><subject>Membrane Proteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>Nerve Growth Factors - physiology</subject><subject>Nervous System - embryology</subject><subject>Netrin-1</subject><subject>Neurons - metabolism</subject><subject>Receptors, Cell Surface - physiology</subject><subject>RNA, Helminth - genetics</subject><subject>Sequence Alignment</subject><subject>Signal Transduction</subject><subject>Tumor Suppressor Proteins</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxS1UBAv0T0DyqQKJwDiOHftUVeZT4kNqy9nyOpOVq2y82NlKnPjXSdgVV05z-L2ZN3qPkGMG5wyYvPgDoMtCybo6AThVjPO60DtkxkDXRcXq8huZfUr2yUHO_wBACSH2yJ5SkmngM_L2_GiKCs6oo-acYocL12d6G5exiwsaW3ppDD25HMGADQ09NSNI6AfXUeN6j-n0jN5l-htf1iFtJA9xCB1Sg103gbyKfRP6BR0indwkfcQhTafWmI_Ibuu6jN-385A8X1_9NbfF_dPNnfl1X3gh5FBIVtYafKt51ZSAcykUeF1VpUAhQEEtEXyjeCnmWrXgSuUlZ5K7lnk2b1t-SH5s7q5SfBl9B7sM2Y8fuh7jOttaVVyLWn8pZEJpzqpJKDZCn2LOCVu7SmHp0qtlYKeG7EdDdorfAtiPhuy0d7w1WM-X2HxubSsZ-c8NxzGO_wGTzT7gmHQTptxtE8MXDu9dN5wh</recordid><startdate>19961018</startdate><enddate>19961018</enddate><creator>Chan, S.S.-Y.</creator><creator>Zheng, H.</creator><creator>Su, M.-W.</creator><creator>Wilk, R.</creator><creator>Killeen, M.T.</creator><creator>Hedgecock, E.M.</creator><creator>Culotti, J.G.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19961018</creationdate><title>UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues</title><author>Chan, S.S.-Y. ; Zheng, H. ; Su, M.-W. ; Wilk, R. ; Killeen, M.T. ; Hedgecock, E.M. ; Culotti, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-612790cf934d20eb6580c94425e5508076e0cd8325b98f0a28c63163af1c1bff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>caenorhabditis elegans</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - growth & development</topic><topic>Caenorhabditis elegans Proteins</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Cell Movement</topic><topic>Cloning, Molecular</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Helminth</topic><topic>Membrane Proteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>Nerve Growth Factors - physiology</topic><topic>Nervous System - embryology</topic><topic>Netrin-1</topic><topic>Neurons - metabolism</topic><topic>Receptors, Cell Surface - physiology</topic><topic>RNA, Helminth - genetics</topic><topic>Sequence Alignment</topic><topic>Signal Transduction</topic><topic>Tumor Suppressor Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, S.S.-Y.</creatorcontrib><creatorcontrib>Zheng, H.</creatorcontrib><creatorcontrib>Su, M.-W.</creatorcontrib><creatorcontrib>Wilk, R.</creatorcontrib><creatorcontrib>Killeen, M.T.</creatorcontrib><creatorcontrib>Hedgecock, E.M.</creatorcontrib><creatorcontrib>Culotti, J.G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, S.S.-Y.</au><au>Zheng, H.</au><au>Su, M.-W.</au><au>Wilk, R.</au><au>Killeen, M.T.</au><au>Hedgecock, E.M.</au><au>Culotti, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1996-10-18</date><risdate>1996</risdate><volume>87</volume><issue>2</issue><spage>187</spage><epage>195</epage><pages>187-195</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8861903</pmid><doi>10.1016/S0092-8674(00)81337-9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins Cell Adhesion Molecules - physiology Cell Movement Cloning, Molecular Gene Expression Regulation, Developmental Genes, Helminth Membrane Proteins - genetics Molecular Sequence Data Nerve Growth Factors - physiology Nervous System - embryology Netrin-1 Neurons - metabolism Receptors, Cell Surface - physiology RNA, Helminth - genetics Sequence Alignment Signal Transduction Tumor Suppressor Proteins |
| title | UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues |
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