Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI
We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 18 men with chronic schizophrenia and in 18 age-matched healthy subjects to test in living patients the findings of a previous postmortem study. The schizophrenic patients showed bilaterally shortening (left, −6%; right, −9%) a...
Gespeichert in:
| Veröffentlicht in: | Biological psychiatry (1969) 1996-06, Vol.39 (11), p.938-945 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 945 |
|---|---|
| container_issue | 11 |
| container_start_page | 938 |
| container_title | Biological psychiatry (1969) |
| container_volume | 39 |
| creator | Fukuzako, Hiroshi Fukuzako, Tsuyoshi Hashiguchi, Tomo Hokazono, Yoshiro Takeuchi, Kouzou Hirakawa, Kyuroku Ueyama, Kenichi Takigawa, Morikuni Kajiya, Yoshiki Nakajo, Masayuki Fujimoto, Toshiro |
| description | We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 18 men with chronic schizophrenia and in 18 age-matched healthy subjects to test in living patients the findings of a previous postmortem study. The schizophrenic patients showed bilaterally shortening (left, −6%; right, −9%) and volume reduction (left, −9%; right, −11%) of the hippocampal formation (HF). Volumes of HF correlated positively with HF length in the schizophrenic patients. The reduction in bilateral HF volumes was small after controlling for HF lengths (left, −3%; right, −3%). In schizophrenic patients, significant negative correlations were found bilaterally between the length of HF's and the scores for attention, bizarre behavior, and positive formal thought disorder. The results suggest that the volume reduction seen in the HF's of schizophrenic patients was caused mainly by a shortening of the HF and that these clinical symptoms may be associated with shorter HF length. |
| doi_str_mv | 10.1016/0006-3223(95)00251-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78439492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006322395002510</els_id><sourcerecordid>78439492</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-7bc1dbc09e4daf4956a39587af01eca41ab6d88d450a45214a571a62a25d13463</originalsourceid><addsrcrecordid>eNp9kEGL1TAUhYMo45vRf6CQhYguqkmatI0LYRhGHRgRBl2H2yS1kTapue3g89fbznu8patwOd85hI-QF5y944xX7xljVVEKUb7R6i1jQvGCPSI73tRlISQTj8nuhDwl54i_1rMWgp-RM80rIZjakT933i12DinSEGkfpilZGCcYaJfyCA_BfRqW0dOA1MKC3tERQhz2tN3TMCPFPuXZxxB_bhO2zykGS9H24W-a-rwm8IFeInrE0cd5q329u3lGnnQwoH9-fC_Ij0_X36--FLffPt9cXd4WVjZ8LurWctdapr100EmtKii1amroGPcWJIe2ck3jpGIgleASVM2hEiCU46Wsygvy-rA75fR78TibMaD1wwDRpwVN3chSSy1WUB5AmxNi9p2Zchgh7w1nZhNuNptms2m0Mg_CDVtrL4_7Szt6dyodDa_5q2MOaGHoMkQb8ISVXHCt9Ip9PGB-dXEffDZog4_Wu5C9nY1L4f__-AfwRp1X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78439492</pqid></control><display><type>article</type><title>Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Fukuzako, Hiroshi ; Fukuzako, Tsuyoshi ; Hashiguchi, Tomo ; Hokazono, Yoshiro ; Takeuchi, Kouzou ; Hirakawa, Kyuroku ; Ueyama, Kenichi ; Takigawa, Morikuni ; Kajiya, Yoshiki ; Nakajo, Masayuki ; Fujimoto, Toshiro</creator><creatorcontrib>Fukuzako, Hiroshi ; Fukuzako, Tsuyoshi ; Hashiguchi, Tomo ; Hokazono, Yoshiro ; Takeuchi, Kouzou ; Hirakawa, Kyuroku ; Ueyama, Kenichi ; Takigawa, Morikuni ; Kajiya, Yoshiki ; Nakajo, Masayuki ; Fujimoto, Toshiro</creatorcontrib><description>We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 18 men with chronic schizophrenia and in 18 age-matched healthy subjects to test in living patients the findings of a previous postmortem study. The schizophrenic patients showed bilaterally shortening (left, −6%; right, −9%) and volume reduction (left, −9%; right, −11%) of the hippocampal formation (HF). Volumes of HF correlated positively with HF length in the schizophrenic patients. The reduction in bilateral HF volumes was small after controlling for HF lengths (left, −3%; right, −3%). In schizophrenic patients, significant negative correlations were found bilaterally between the length of HF's and the scores for attention, bizarre behavior, and positive formal thought disorder. The results suggest that the volume reduction seen in the HF's of schizophrenic patients was caused mainly by a shortening of the HF and that these clinical symptoms may be associated with shorter HF length.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(95)00251-0</identifier><identifier>PMID: 9162205</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Chronic Disease ; disorganization ; Functional Laterality - physiology ; Hippocampal formation ; Hippocampus - pathology ; Humans ; Image Processing, Computer-Assisted ; length and volume ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - pathology ; Schizophrenic Psychology</subject><ispartof>Biological psychiatry (1969), 1996-06, Vol.39 (11), p.938-945</ispartof><rights>1996 Society of Biological Psychiatry</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-7bc1dbc09e4daf4956a39587af01eca41ab6d88d450a45214a571a62a25d13463</citedby><cites>FETCH-LOGICAL-c481t-7bc1dbc09e4daf4956a39587af01eca41ab6d88d450a45214a571a62a25d13463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-3223(95)00251-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3121959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9162205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuzako, Hiroshi</creatorcontrib><creatorcontrib>Fukuzako, Tsuyoshi</creatorcontrib><creatorcontrib>Hashiguchi, Tomo</creatorcontrib><creatorcontrib>Hokazono, Yoshiro</creatorcontrib><creatorcontrib>Takeuchi, Kouzou</creatorcontrib><creatorcontrib>Hirakawa, Kyuroku</creatorcontrib><creatorcontrib>Ueyama, Kenichi</creatorcontrib><creatorcontrib>Takigawa, Morikuni</creatorcontrib><creatorcontrib>Kajiya, Yoshiki</creatorcontrib><creatorcontrib>Nakajo, Masayuki</creatorcontrib><creatorcontrib>Fujimoto, Toshiro</creatorcontrib><title>Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 18 men with chronic schizophrenia and in 18 age-matched healthy subjects to test in living patients the findings of a previous postmortem study. The schizophrenic patients showed bilaterally shortening (left, −6%; right, −9%) and volume reduction (left, −9%; right, −11%) of the hippocampal formation (HF). Volumes of HF correlated positively with HF length in the schizophrenic patients. The reduction in bilateral HF volumes was small after controlling for HF lengths (left, −3%; right, −3%). In schizophrenic patients, significant negative correlations were found bilaterally between the length of HF's and the scores for attention, bizarre behavior, and positive formal thought disorder. The results suggest that the volume reduction seen in the HF's of schizophrenic patients was caused mainly by a shortening of the HF and that these clinical symptoms may be associated with shorter HF length.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>disorganization</subject><subject>Functional Laterality - physiology</subject><subject>Hippocampal formation</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>length and volume</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenic Psychology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEGL1TAUhYMo45vRf6CQhYguqkmatI0LYRhGHRgRBl2H2yS1kTapue3g89fbznu8patwOd85hI-QF5y944xX7xljVVEKUb7R6i1jQvGCPSI73tRlISQTj8nuhDwl54i_1rMWgp-RM80rIZjakT933i12DinSEGkfpilZGCcYaJfyCA_BfRqW0dOA1MKC3tERQhz2tN3TMCPFPuXZxxB_bhO2zykGS9H24W-a-rwm8IFeInrE0cd5q329u3lGnnQwoH9-fC_Ij0_X36--FLffPt9cXd4WVjZ8LurWctdapr100EmtKii1amroGPcWJIe2ck3jpGIgleASVM2hEiCU46Wsygvy-rA75fR78TibMaD1wwDRpwVN3chSSy1WUB5AmxNi9p2Zchgh7w1nZhNuNptms2m0Mg_CDVtrL4_7Szt6dyodDa_5q2MOaGHoMkQb8ISVXHCt9Ip9PGB-dXEffDZog4_Wu5C9nY1L4f__-AfwRp1X</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Fukuzako, Hiroshi</creator><creator>Fukuzako, Tsuyoshi</creator><creator>Hashiguchi, Tomo</creator><creator>Hokazono, Yoshiro</creator><creator>Takeuchi, Kouzou</creator><creator>Hirakawa, Kyuroku</creator><creator>Ueyama, Kenichi</creator><creator>Takigawa, Morikuni</creator><creator>Kajiya, Yoshiki</creator><creator>Nakajo, Masayuki</creator><creator>Fujimoto, Toshiro</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI</title><author>Fukuzako, Hiroshi ; Fukuzako, Tsuyoshi ; Hashiguchi, Tomo ; Hokazono, Yoshiro ; Takeuchi, Kouzou ; Hirakawa, Kyuroku ; Ueyama, Kenichi ; Takigawa, Morikuni ; Kajiya, Yoshiki ; Nakajo, Masayuki ; Fujimoto, Toshiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-7bc1dbc09e4daf4956a39587af01eca41ab6d88d450a45214a571a62a25d13463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>disorganization</topic><topic>Functional Laterality - physiology</topic><topic>Hippocampal formation</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>length and volume</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenic Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuzako, Hiroshi</creatorcontrib><creatorcontrib>Fukuzako, Tsuyoshi</creatorcontrib><creatorcontrib>Hashiguchi, Tomo</creatorcontrib><creatorcontrib>Hokazono, Yoshiro</creatorcontrib><creatorcontrib>Takeuchi, Kouzou</creatorcontrib><creatorcontrib>Hirakawa, Kyuroku</creatorcontrib><creatorcontrib>Ueyama, Kenichi</creatorcontrib><creatorcontrib>Takigawa, Morikuni</creatorcontrib><creatorcontrib>Kajiya, Yoshiki</creatorcontrib><creatorcontrib>Nakajo, Masayuki</creatorcontrib><creatorcontrib>Fujimoto, Toshiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuzako, Hiroshi</au><au>Fukuzako, Tsuyoshi</au><au>Hashiguchi, Tomo</au><au>Hokazono, Yoshiro</au><au>Takeuchi, Kouzou</au><au>Hirakawa, Kyuroku</au><au>Ueyama, Kenichi</au><au>Takigawa, Morikuni</au><au>Kajiya, Yoshiki</au><au>Nakajo, Masayuki</au><au>Fujimoto, Toshiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>39</volume><issue>11</issue><spage>938</spage><epage>945</epage><pages>938-945</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 18 men with chronic schizophrenia and in 18 age-matched healthy subjects to test in living patients the findings of a previous postmortem study. The schizophrenic patients showed bilaterally shortening (left, −6%; right, −9%) and volume reduction (left, −9%; right, −11%) of the hippocampal formation (HF). Volumes of HF correlated positively with HF length in the schizophrenic patients. The reduction in bilateral HF volumes was small after controlling for HF lengths (left, −3%; right, −3%). In schizophrenic patients, significant negative correlations were found bilaterally between the length of HF's and the scores for attention, bizarre behavior, and positive formal thought disorder. The results suggest that the volume reduction seen in the HF's of schizophrenic patients was caused mainly by a shortening of the HF and that these clinical symptoms may be associated with shorter HF length.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9162205</pmid><doi>10.1016/0006-3223(95)00251-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 1996-06, Vol.39 (11), p.938-945 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78439492 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Chronic Disease disorganization Functional Laterality - physiology Hippocampal formation Hippocampus - pathology Humans Image Processing, Computer-Assisted length and volume Magnetic Resonance Imaging Male Medical sciences Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - pathology Schizophrenic Psychology |
| title | Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T22%3A48%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduction%20in%20hippocampal%20formation%20volume%20is%20caused%20mainly%20by%20its%20shortening%20in%20chronic%20schizophrenia:%20Assessment%20by%20MRI&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=Fukuzako,%20Hiroshi&rft.date=1996-06-01&rft.volume=39&rft.issue=11&rft.spage=938&rft.epage=945&rft.pages=938-945&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/0006-3223(95)00251-0&rft_dat=%3Cproquest_cross%3E78439492%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78439492&rft_id=info:pmid/9162205&rft_els_id=0006322395002510&rfr_iscdi=true |