Chromosome painting of radiation-induced micronuclei
In this report, in situ hybridization with whole chromosome painting probes was used to paint radiationinduced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a signif...
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| Veröffentlicht in: | International journal of radiation biology 1996-10, Vol.70 (4), p.393-401 |
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| container_end_page | 401 |
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| container_issue | 4 |
| container_start_page | 393 |
| container_title | International journal of radiation biology |
| container_volume | 70 |
| creator | SLAVOTINEK, S. SAUER-NEHLS, H. BRASELMANN, G. M. TAYLOR and M. NUSSE, A. |
| description | In this report, in situ hybridization with whole chromosome painting probes was used to paint radiationinduced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of the numbers of signalpositive MN from that expected on the basis of DNA proportionality. Restriction of the analysis to three chromosomes showed that the deviations arose primarily from chromosome 7, which was underrepresented in the numbers of signalpositive MN in the group of chromosomes studied. |
| doi_str_mv | 10.1080/095530096144860 |
| format | Article |
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SAUER-NEHLS, H. BRASELMANN, G. M. TAYLOR and M. NUSSE, A.</creatorcontrib><title>Chromosome painting of radiation-induced micronuclei</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>In this report, in situ hybridization with whole chromosome painting probes was used to paint radiationinduced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of the numbers of signalpositive MN from that expected on the basis of DNA proportionality. Restriction of the analysis to three chromosomes showed that the deviations arose primarily from chromosome 7, which was underrepresented in the numbers of signalpositive MN in the group of chromosomes studied.</description><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cell Nucleus - drug effects</subject><subject>Chromosomes, Human - radiation effects</subject><subject>Cytochalasin B - pharmacology</subject><subject>Cytogenetics - methods</subject><subject>Fluorescein-5-isothiocyanate</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Karyotyping</subject><subject>Lymphocytes - radiation effects</subject><subject>Lymphocytes - ultrastructure</subject><subject>Micronuclei, Chromosome-Defective - radiation effects</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutagenesis. 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Psychology</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Karyotyping</topic><topic>Lymphocytes - radiation effects</topic><topic>Lymphocytes - ultrastructure</topic><topic>Micronuclei, Chromosome-Defective - radiation effects</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Mutagenesis. Repair</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SLAVOTINEK, S. SAUER-NEHLS, H. BRASELMANN, G. M. TAYLOR and M. 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NUSSE, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome painting of radiation-induced micronuclei</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>70</volume><issue>4</issue><spage>393</spage><epage>401</epage><pages>393-401</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>In this report, in situ hybridization with whole chromosome painting probes was used to paint radiationinduced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of the numbers of signalpositive MN from that expected on the basis of DNA proportionality. 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| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1996-10, Vol.70 (4), p.393-401 |
| issn | 0955-3002 1362-3095 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Biological and medical sciences Cell Division - drug effects Cell Line Cell Nucleus - drug effects Chromosomes, Human - radiation effects Cytochalasin B - pharmacology Cytogenetics - methods Fluorescein-5-isothiocyanate Fundamental and applied biological sciences. Psychology Humans In Situ Hybridization Karyotyping Lymphocytes - radiation effects Lymphocytes - ultrastructure Micronuclei, Chromosome-Defective - radiation effects Molecular and cellular biology Molecular genetics Mutagenesis. Repair Space life sciences |
| title | Chromosome painting of radiation-induced micronuclei |
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