Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis
Proinflammatory cytokine release was measured from peripheral blood mononuclear cells (PBMCs) isolated from six volunteers and, on admission, from 16 patients with acute pancreatitis. Tumour necrosis factor (TNF) release in patients did not differ significantly from that of volunteers, whereas both...
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| Veröffentlicht in: | British journal of surgery 1996-08, Vol.83 (8), p.1071-1075 |
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| container_title | British journal of surgery |
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| creator | de Beaux, A. C. Ross, J. A. Maingay, J. P. Fearon, K. C. H. Carter, D. C. |
| description | Proinflammatory cytokine release was measured from peripheral blood mononuclear cells (PBMCs) isolated from six volunteers and, on admission, from 16 patients with acute pancreatitis. Tumour necrosis factor (TNF) release in patients did not differ significantly from that of volunteers, whereas both interleukin (IL) 6 and IL‐8 release in patients was raised when compared with that in the volunteer group (mean(s.e.m.) IL‐6 20.7(4.6) versus 9.3(1.7) ng/ml, P = 0.03; IL‐8 283(40) versus 128(22) ng/ml, P = 0.04). When variation in white cell count was accounted for, IL‐6 and IL‐8 release but not that of TNF was significantly greater in patients with severe disease than in those with mild disease. These results point to a complex upregulation of proinflammatory cytokine release from PBMCs in patients with acute pancreatitis, components of which relate to the clinical progress of the disease. |
| doi_str_mv | 10.1002/bjs.1800830811 |
| format | Article |
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C. ; Ross, J. A. ; Maingay, J. P. ; Fearon, K. C. H. ; Carter, D. C.</creator><creatorcontrib>de Beaux, A. C. ; Ross, J. A. ; Maingay, J. P. ; Fearon, K. C. H. ; Carter, D. C.</creatorcontrib><description>Proinflammatory cytokine release was measured from peripheral blood mononuclear cells (PBMCs) isolated from six volunteers and, on admission, from 16 patients with acute pancreatitis. Tumour necrosis factor (TNF) release in patients did not differ significantly from that of volunteers, whereas both interleukin (IL) 6 and IL‐8 release in patients was raised when compared with that in the volunteer group (mean(s.e.m.) IL‐6 20.7(4.6) versus 9.3(1.7) ng/ml, P = 0.03; IL‐8 283(40) versus 128(22) ng/ml, P = 0.04). When variation in white cell count was accounted for, IL‐6 and IL‐8 release but not that of TNF was significantly greater in patients with severe disease than in those with mild disease. These results point to a complex upregulation of proinflammatory cytokine release from PBMCs in patients with acute pancreatitis, components of which relate to the clinical progress of the disease.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800830811</identifier><identifier>PMID: 8869305</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Interleukin-6 - metabolism ; Interleukin-8 - metabolism ; Leukocytes, Mononuclear - metabolism ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pancreatitis - blood ; Sex Ratio ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>British journal of surgery, 1996-08, Vol.83 (8), p.1071-1075</ispartof><rights>Copyright © 1996 British Journal of Surgery Society Ltd.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4081-b9e637922a02c31596b3d4d47361290848aa603edd7a99e6e1815eba8f1838843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800830811$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800830811$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3164328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8869305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Beaux, A. C.</creatorcontrib><creatorcontrib>Ross, J. A.</creatorcontrib><creatorcontrib>Maingay, J. P.</creatorcontrib><creatorcontrib>Fearon, K. C. H.</creatorcontrib><creatorcontrib>Carter, D. C.</creatorcontrib><title>Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Proinflammatory cytokine release was measured from peripheral blood mononuclear cells (PBMCs) isolated from six volunteers and, on admission, from 16 patients with acute pancreatitis. Tumour necrosis factor (TNF) release in patients did not differ significantly from that of volunteers, whereas both interleukin (IL) 6 and IL‐8 release in patients was raised when compared with that in the volunteer group (mean(s.e.m.) IL‐6 20.7(4.6) versus 9.3(1.7) ng/ml, P = 0.03; IL‐8 283(40) versus 128(22) ng/ml, P = 0.04). When variation in white cell count was accounted for, IL‐6 and IL‐8 release but not that of TNF was significantly greater in patients with severe disease than in those with mild disease. These results point to a complex upregulation of proinflammatory cytokine release from PBMCs in patients with acute pancreatitis, components of which relate to the clinical progress of the disease.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukin-8 - metabolism</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pancreatitis - blood</subject><subject>Sex Ratio</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1v1DAQxS0EKkvhyg3JB8QtxR-J4xxhRbdfAiRAPVqTZKK6deJgOyr573G1q-3J9rzfG834EfKeszPOmPjc3sczrhnTkmnOX5ANl6oqBFf6JdkwxuqCSyFfkzcx3jPGJavECTnRWjX5uiHuZ_B2GhyMIyQfVtqtyT_YCWlAhxCRtiudMdj5DgM42jrvezr6yU9Ll4FAO3Qu0iH4kc6QLE4p0keb7ih0S8Jcm7qAWUg2viWvBnAR3x3OU_Ln_Nvv7UVx82N3uf1yU3RlXqJoG1SyboQAJjrJq0a1si_7spaKi4bpUgMoJrHva2gyi1zzClvQA9dS61Kekk_7vnPwfxeMyYw2Ps0JE_olmjozdSVkBj8cwKUdsTdzsCOE1Ry-J-sfDzrEDtwQ8jI2HjHJVSmFzlizxx6tw_Uoc2aeIjI5IvMckfl69ev5lb3F3mtjwn9HL4QHo-o8pbn9vjO7893tRXO1NdfyPxDflQ4</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>de Beaux, A. C.</creator><creator>Ross, J. A.</creator><creator>Maingay, J. P.</creator><creator>Fearon, K. C. H.</creator><creator>Carter, D. C.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199608</creationdate><title>Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis</title><author>de Beaux, A. C. ; Ross, J. A. ; Maingay, J. P. ; Fearon, K. C. H. ; Carter, D. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4081-b9e637922a02c31596b3d4d47361290848aa603edd7a99e6e1815eba8f1838843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Interleukin-6 - metabolism</topic><topic>Interleukin-8 - metabolism</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis - blood</topic><topic>Sex Ratio</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Beaux, A. C.</creatorcontrib><creatorcontrib>Ross, J. A.</creatorcontrib><creatorcontrib>Maingay, J. P.</creatorcontrib><creatorcontrib>Fearon, K. C. H.</creatorcontrib><creatorcontrib>Carter, D. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Beaux, A. C.</au><au>Ross, J. A.</au><au>Maingay, J. P.</au><au>Fearon, K. C. H.</au><au>Carter, D. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1996-08</date><risdate>1996</risdate><volume>83</volume><issue>8</issue><spage>1071</spage><epage>1075</epage><pages>1071-1075</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Proinflammatory cytokine release was measured from peripheral blood mononuclear cells (PBMCs) isolated from six volunteers and, on admission, from 16 patients with acute pancreatitis. Tumour necrosis factor (TNF) release in patients did not differ significantly from that of volunteers, whereas both interleukin (IL) 6 and IL‐8 release in patients was raised when compared with that in the volunteer group (mean(s.e.m.) IL‐6 20.7(4.6) versus 9.3(1.7) ng/ml, P = 0.03; IL‐8 283(40) versus 128(22) ng/ml, P = 0.04). When variation in white cell count was accounted for, IL‐6 and IL‐8 release but not that of TNF was significantly greater in patients with severe disease than in those with mild disease. These results point to a complex upregulation of proinflammatory cytokine release from PBMCs in patients with acute pancreatitis, components of which relate to the clinical progress of the disease.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8869305</pmid><doi>10.1002/bjs.1800830811</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Acute Disease Adult Aged Aged, 80 and over Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Gastroenterology. Liver. Pancreas. Abdomen Humans Interleukin-6 - metabolism Interleukin-8 - metabolism Leukocytes, Mononuclear - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Pancreatitis - blood Sex Ratio Tumor Necrosis Factor-alpha - metabolism |
| title | Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis |
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