Development of T-cell lines expressing functional HIV-1 envelope glycoproteins for evaluation of immune responses in HIV-infected individuals

The human T-lymphoid cell line, CEM, was transfected with gp 160 cDNA of human immunodeficiency virus type 1 (HIV-1)pm213. Three clones expressing the envelope glycoproteins (env), designated CEM-213env1, -env4, and -env7, were isolated. These clones expressed high levels of surface gp41 and gp120,...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes and human retrovirology 1996-10, Vol.13 (2), p.117-126
Hauptverfasser:	KELER, T, LI, H, CLOYD, M. W, VITALE, L. A, DEO, Y. M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences Blotting, Western CD4 Antigens - metabolism Cells, Cultured Clone Cells - immunology Clone Cells - virology Cytotoxicity, Immunologic Down-Regulation Epitopes - immunology Flow Cytometry Gene Expression Regulation, Viral Giant Cells - virology HeLa Cells - virology HIV Envelope Protein gp120 - biosynthesis HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp160 - biosynthesis HIV Envelope Protein gp160 - genetics HIV Envelope Protein gp160 - immunology HIV Envelope Protein gp41 - biosynthesis HIV Envelope Protein gp41 - immunology HIV Infections - immunology HIV Infections - virology HIV-1 human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Medical sciences T-Lymphocytes - immunology T-Lymphocytes - virology Transfection
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