A prolactin-secreting tumor in a patient with Klinefelter's syndrome : A case report
We report the case of a patient with Klinefelter's syndrome who developed a prolactin (PRL)-secreting tumor. The patient developed headaches, visual alterations and also symptoms of hypogonadism despite appropriate testosterone (T) replacement therapy. The diagnosis of hyperprolactinemia was th...
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| Veröffentlicht in: | Journal of endocrinological investigation 1996-04, Vol.19 (4), p.248-252 |
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| container_title | Journal of endocrinological investigation |
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| creator | PINTO, A.-C. A. R CZEPIELEWSKI, M. A GROSS, J. L MUSSIO, W LENGYEL, A.-M. J |
| description | We report the case of a patient with Klinefelter's syndrome who developed a prolactin (PRL)-secreting tumor. The patient developed headaches, visual alterations and also symptoms of hypogonadism despite appropriate testosterone (T) replacement therapy. The diagnosis of hyperprolactinemia was then suspected. The laboratory findings confirmed the hypothesis, showing high levels of serum PRL. The patient was initially treated with oral bromocriptine, and afterwards with the injectable form. There was a marked decrease in PRL levels and in tumor size. Although some neoplasms, like breast carcinoma and germ cell tumors, are known to occur more frequently in patients with Klinefelter's syndrome, an association with PRL-secreting tumor has not been reported yet. In conclusion, symptoms of hypogonadism in patients with Klinefelter's syndrome receiving appropriate T replacement therapy can suggest the presence of hyperprolactinemia. |
| doi_str_mv | 10.1007/BF03349876 |
| format | Article |
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A. R ; CZEPIELEWSKI, M. A ; GROSS, J. L ; MUSSIO, W ; LENGYEL, A.-M. J</creator><creatorcontrib>PINTO, A.-C. A. R ; CZEPIELEWSKI, M. A ; GROSS, J. L ; MUSSIO, W ; LENGYEL, A.-M. J</creatorcontrib><description>We report the case of a patient with Klinefelter's syndrome who developed a prolactin (PRL)-secreting tumor. The patient developed headaches, visual alterations and also symptoms of hypogonadism despite appropriate testosterone (T) replacement therapy. The diagnosis of hyperprolactinemia was then suspected. The laboratory findings confirmed the hypothesis, showing high levels of serum PRL. The patient was initially treated with oral bromocriptine, and afterwards with the injectable form. There was a marked decrease in PRL levels and in tumor size. Although some neoplasms, like breast carcinoma and germ cell tumors, are known to occur more frequently in patients with Klinefelter's syndrome, an association with PRL-secreting tumor has not been reported yet. In conclusion, symptoms of hypogonadism in patients with Klinefelter's syndrome receiving appropriate T replacement therapy can suggest the presence of hyperprolactinemia.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03349876</identifier><identifier>PMID: 8862506</identifier><identifier>CODEN: JEIND7</identifier><language>eng</language><publisher>Milano: Kurtis</publisher><subject>Adenoma - diagnosis ; Adenoma - secretion ; Adult ; Biological and medical sciences ; Chromosome aberrations ; Humans ; Hyperprolactinemia - diagnosis ; Hyperprolactinemia - etiology ; Hypogonadism - etiology ; Hypogonadism - physiopathology ; Klinefelter Syndrome - complications ; Klinefelter Syndrome - drug therapy ; Klinefelter Syndrome - physiopathology ; Male ; Medical genetics ; Medical sciences ; Prolactin - secretion ; Testosterone - therapeutic use</subject><ispartof>Journal of endocrinological investigation, 1996-04, Vol.19 (4), p.248-252</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-a9aecc9df69a9351c2afccaf2ef2fc48659b337aa10790826d26b9179edc38793</citedby><cites>FETCH-LOGICAL-c311t-a9aecc9df69a9351c2afccaf2ef2fc48659b337aa10790826d26b9179edc38793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3128329$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8862506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PINTO, A.-C. A. R</creatorcontrib><creatorcontrib>CZEPIELEWSKI, M. A</creatorcontrib><creatorcontrib>GROSS, J. L</creatorcontrib><creatorcontrib>MUSSIO, W</creatorcontrib><creatorcontrib>LENGYEL, A.-M. J</creatorcontrib><title>A prolactin-secreting tumor in a patient with Klinefelter's syndrome : A case report</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>We report the case of a patient with Klinefelter's syndrome who developed a prolactin (PRL)-secreting tumor. The patient developed headaches, visual alterations and also symptoms of hypogonadism despite appropriate testosterone (T) replacement therapy. The diagnosis of hyperprolactinemia was then suspected. The laboratory findings confirmed the hypothesis, showing high levels of serum PRL. The patient was initially treated with oral bromocriptine, and afterwards with the injectable form. There was a marked decrease in PRL levels and in tumor size. Although some neoplasms, like breast carcinoma and germ cell tumors, are known to occur more frequently in patients with Klinefelter's syndrome, an association with PRL-secreting tumor has not been reported yet. In conclusion, symptoms of hypogonadism in patients with Klinefelter's syndrome receiving appropriate T replacement therapy can suggest the presence of hyperprolactinemia.</description><subject>Adenoma - diagnosis</subject><subject>Adenoma - secretion</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chromosome aberrations</subject><subject>Humans</subject><subject>Hyperprolactinemia - diagnosis</subject><subject>Hyperprolactinemia - etiology</subject><subject>Hypogonadism - etiology</subject><subject>Hypogonadism - physiopathology</subject><subject>Klinefelter Syndrome - complications</subject><subject>Klinefelter Syndrome - drug therapy</subject><subject>Klinefelter Syndrome - physiopathology</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Prolactin - secretion</subject><subject>Testosterone - therapeutic use</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotVY37oUsREEYzWNmkrirxRcW3NT1cJu50ZF51CSD9N87paWu7oXzceB8hJxzdssZU3cPT0zK1GiVH5AxV4IlWur8kIyZNDxJmVHH5CSEb8akklqNyEjrXGQsH5PFlK58V4ONVZsEtB6H55PGvuk8rVoKdAWxwjbS3yp-0be6atFhHdFfBxrWbem7Buk9nVILAanHVefjKTlyUAc8290J-Xh6XMxekvn78-tsOk-s5DwmYACtNaXLDRiZcSvAWQtOoBPOpjrPzFJKBcCZMkyLvBT50nBlsLTDDCMn5GrbO0z46THEoqmCxbqGFrs-FEqnMsuyDXizBa3vQvDoipWvGvDrgrNio7D4VzjAF7vWftlguUd3zob8cpdDsFA7D62twh6TXGgpjPwD50p4Dw</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>PINTO, A.-C. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-a9aecc9df69a9351c2afccaf2ef2fc48659b337aa10790826d26b9179edc38793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenoma - diagnosis</topic><topic>Adenoma - secretion</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chromosome aberrations</topic><topic>Humans</topic><topic>Hyperprolactinemia - diagnosis</topic><topic>Hyperprolactinemia - etiology</topic><topic>Hypogonadism - etiology</topic><topic>Hypogonadism - physiopathology</topic><topic>Klinefelter Syndrome - complications</topic><topic>Klinefelter Syndrome - drug therapy</topic><topic>Klinefelter Syndrome - physiopathology</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Prolactin - secretion</topic><topic>Testosterone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PINTO, A.-C. A. R</creatorcontrib><creatorcontrib>CZEPIELEWSKI, M. A</creatorcontrib><creatorcontrib>GROSS, J. L</creatorcontrib><creatorcontrib>MUSSIO, W</creatorcontrib><creatorcontrib>LENGYEL, A.-M. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PINTO, A.-C. A. R</au><au>CZEPIELEWSKI, M. A</au><au>GROSS, J. L</au><au>MUSSIO, W</au><au>LENGYEL, A.-M. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prolactin-secreting tumor in a patient with Klinefelter's syndrome : A case report</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>19</volume><issue>4</issue><spage>248</spage><epage>252</epage><pages>248-252</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><coden>JEIND7</coden><abstract>We report the case of a patient with Klinefelter's syndrome who developed a prolactin (PRL)-secreting tumor. The patient developed headaches, visual alterations and also symptoms of hypogonadism despite appropriate testosterone (T) replacement therapy. The diagnosis of hyperprolactinemia was then suspected. The laboratory findings confirmed the hypothesis, showing high levels of serum PRL. The patient was initially treated with oral bromocriptine, and afterwards with the injectable form. There was a marked decrease in PRL levels and in tumor size. Although some neoplasms, like breast carcinoma and germ cell tumors, are known to occur more frequently in patients with Klinefelter's syndrome, an association with PRL-secreting tumor has not been reported yet. In conclusion, symptoms of hypogonadism in patients with Klinefelter's syndrome receiving appropriate T replacement therapy can suggest the presence of hyperprolactinemia.</abstract><cop>Milano</cop><pub>Kurtis</pub><pmid>8862506</pmid><doi>10.1007/BF03349876</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0391-4097 |
| ispartof | Journal of endocrinological investigation, 1996-04, Vol.19 (4), p.248-252 |
| issn | 0391-4097 1720-8386 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenoma - diagnosis Adenoma - secretion Adult Biological and medical sciences Chromosome aberrations Humans Hyperprolactinemia - diagnosis Hyperprolactinemia - etiology Hypogonadism - etiology Hypogonadism - physiopathology Klinefelter Syndrome - complications Klinefelter Syndrome - drug therapy Klinefelter Syndrome - physiopathology Male Medical genetics Medical sciences Prolactin - secretion Testosterone - therapeutic use |
| title | A prolactin-secreting tumor in a patient with Klinefelter's syndrome : A case report |
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