Lymphocyte activation by HIV-1 envelope glycoprotein

Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been...

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Veröffentlicht in:	Nature (London) 1988-09, Vol.335 (6189), p.445-448
Hauptverfasser:	Kornfeld, Hardy, Cruikshank, William W, Pyle, Stephen W, Berman, Jeffrey S, Center, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biochemistry Biological and medical sciences Calcium - blood Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology HIV HIV Envelope Protein gp120 Human immunodeficiency virus 1 Humans In Vitro Techniques Inositol 1,4,5-Trisphosphate Inositol Phosphates - biosynthesis Lymphocyte Activation Lymphocytes Microbiology Proteins Receptors, HIV Receptors, Immunologic - biosynthesis Receptors, Interleukin-2 Receptors, Virus - physiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Retroviridae Proteins - physiology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - physiology Viral Envelope Proteins - physiology Virology
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