Lymphocyte activation by HIV-1 envelope glycoprotein
Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been...
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| Veröffentlicht in: | Nature (London) 1988-09, Vol.335 (6189), p.445-448 |
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| creator | Kornfeld, Hardy Cruikshank, William W Pyle, Stephen W Berman, Jeffrey S Center, David M |
| description | Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility. |
| doi_str_mv | 10.1038/335445a0 |
| format | Article |
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The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. 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Psychology ; HIV ; HIV Envelope Protein gp120 ; Human immunodeficiency virus 1 ; Humans ; In Vitro Techniques ; Inositol 1,4,5-Trisphosphate ; Inositol Phosphates - biosynthesis ; Lymphocyte Activation ; Lymphocytes ; Microbiology ; Proteins ; Receptors, HIV ; Receptors, Immunologic - biosynthesis ; Receptors, Interleukin-2 ; Receptors, Virus - physiology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Retroviridae Proteins - physiology ; T-Lymphocytes, Helper-Inducer - metabolism ; T-Lymphocytes, Helper-Inducer - physiology ; Viral Envelope Proteins - physiology ; Virology</subject><ispartof>Nature (London), 1988-09, Vol.335 (6189), p.445-448</ispartof><rights>1989 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.</description><subject>AIDS/HIV</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Chemotaxis, Leukocyte</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV Envelope Protein gp120</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Inositol 1,4,5-Trisphosphate</subject><subject>Inositol Phosphates - biosynthesis</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Microbiology</subject><subject>Proteins</subject><subject>Receptors, HIV</subject><subject>Receptors, Immunologic - biosynthesis</subject><subject>Receptors, Interleukin-2</subject><subject>Receptors, Virus - physiology</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Retroviridae Proteins - physiology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>T-Lymphocytes, Helper-Inducer - physiology</subject><subject>Viral Envelope Proteins - physiology</subject><subject>Virology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LxDAQBuAgiq4f4B9Qioh4qWbynaOIugsLXtRrSeNUK912bdqF_nsjW_fgZU85zMNM5h1CToHeAOXmlnMphHR0h0xAaJUKZfQumVDKTEoNVwfkMIQvSqkELfbJPjOCay0nRMyHxfKz8UOHifNduXJd2dRJPiTT2VsKCdYrrJolJh_V4Jtl23RY1sdkr3BVwJPxPSKvjw8v99N0_vw0u7-bp14Y0aUFl6gLJ5zOHRPWSsglevVuHS_QAKAzqmBceUoVLUCq3BuquOXaascQ-RG5WveNc797DF22KIPHqnI1Nn3IdNwCrBVbIZdMgbSwFTIAG1PaDkFSHr-tIrz4B7-avq1jLBmjIqYMUkd0vUa-bUJosciWbblw7ZABzX4PmP0dMNKzsV-fL_B9A8eLxfrlWHfBu6poXe3LsGGacR13jex8zWrX9S1u6ps5PzBTqK0</recordid><startdate>19880929</startdate><enddate>19880929</enddate><creator>Kornfeld, Hardy</creator><creator>Cruikshank, William W</creator><creator>Pyle, Stephen W</creator><creator>Berman, Jeffrey S</creator><creator>Center, David M</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>KL.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19880929</creationdate><title>Lymphocyte activation by HIV-1 envelope glycoprotein</title><author>Kornfeld, Hardy ; Cruikshank, William W ; Pyle, Stephen W ; Berman, Jeffrey S ; Center, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-f35e7fa4a7ba249951b5ec6d9a3fe811ea86f236c0060f156bc806393797a2ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>AIDS/HIV</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Chemotaxis, Leukocyte</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV Envelope Protein gp120</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Inositol 1,4,5-Trisphosphate</topic><topic>Inositol Phosphates - biosynthesis</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Microbiology</topic><topic>Proteins</topic><topic>Receptors, HIV</topic><topic>Receptors, Immunologic - biosynthesis</topic><topic>Receptors, Interleukin-2</topic><topic>Receptors, Virus - physiology</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Retroviridae Proteins - physiology</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><topic>T-Lymphocytes, Helper-Inducer - physiology</topic><topic>Viral Envelope Proteins - physiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kornfeld, Hardy</creatorcontrib><creatorcontrib>Cruikshank, William W</creatorcontrib><creatorcontrib>Pyle, Stephen W</creatorcontrib><creatorcontrib>Berman, Jeffrey S</creatorcontrib><creatorcontrib>Center, David M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kornfeld, Hardy</au><au>Cruikshank, William W</au><au>Pyle, Stephen W</au><au>Berman, Jeffrey S</au><au>Center, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte activation by HIV-1 envelope glycoprotein</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1988-09-29</date><risdate>1988</risdate><volume>335</volume><issue>6189</issue><spage>445</spage><epage>448</epage><pages>445-448</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. 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| ispartof | Nature (London), 1988-09, Vol.335 (6189), p.445-448 |
| issn | 0028-0836 1476-4687 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | AIDS/HIV Biochemistry Biological and medical sciences Calcium - blood Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology HIV HIV Envelope Protein gp120 Human immunodeficiency virus 1 Humans In Vitro Techniques Inositol 1,4,5-Trisphosphate Inositol Phosphates - biosynthesis Lymphocyte Activation Lymphocytes Microbiology Proteins Receptors, HIV Receptors, Immunologic - biosynthesis Receptors, Interleukin-2 Receptors, Virus - physiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Retroviridae Proteins - physiology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - physiology Viral Envelope Proteins - physiology Virology |
| title | Lymphocyte activation by HIV-1 envelope glycoprotein |
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